Results 91 to 100 of about 6,249 (200)

Multiple roles of Condensins: a complex story [PDF]

Biology of the Cell, 2004
Summry— Condensins are pentameric complexes that were initially described as being involved in the dynamics of chromosomes during mitosis. It has been recently established that two related complexes (Condensin I and Condensin II) contribute to this process.
Legagneux, Vincent, Cubizolles, Fabien, Watrin, Erwan   +2 more
openaire   +2 more sources

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

RNAP II antagonizes mitotic chromatin folding and chromosome segregation by condensin

Cell Reports
Summary: Condensin shapes mitotic chromosomes by folding chromatin into loops, but whether it does so by DNA-loop extrusion remains speculative. Although loop-extruding cohesin is stalled by transcription, the impact of transcription on condensin, which ...
Jérémy Lebreton, Léonard Colin, Elodie Chatre, Pascal Bernard   +3 more
doaj   +1 more source

Condensins and 3D Organization of the Interphase Nucleus [PDF]

Current Genetic Medicine Reports, 2013
Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression,
Heather A, Wallace, Giovanni, Bosco
openaire   +2 more sources

Multinucleation in the Human Embryo's First Mitosis: Linking Spindle Geometry Defects, SAC Tolerance, Chromosome Segregation, and Nuclear Envelope Reassembly

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Multinucleation occurs at high frequency during the first mitosis of human embryos and is associated with impaired developmental potential. Our live‐imaging analyses showed that collapse of spindle geometry—such as low‐aspect ratio spindles and pole defocusing—correlates with multinucleation, yet molecular links from aberrant ...
Yuki Ono, Yukihiro Terada
wiley   +1 more source

Three Distinct Condensin Complexes Control C. elegans Chromosome Dynamics

, 2009
SummaryBackgroundCondensin complexes organize chromosome structure and facilitate chromosome segregation. Higher eukaryotes have two complexes, condensin I and condensin II, each essential for chromosome segregation.
Tabuchi, Tomoko, Collette, Karishma, Spahl, Karin, Sarkeshik, Ali, Hagstrom, Kirsten, Yates, John, Thompson, James, Sarkesik, Ali, McLeod, Ian, Petty, Emily, Meyer, Barbara, Meyer, Barbara J., Snyder, Martha, Liu, Hongbin, Csankovszki, Gyorgyi, Patel, Uchita, Carey, James   +16 more
core   +1 more source

Identifying Prognostic Biomarkers and Key Pathways in Renal Clear Cell Carcinoma: A Pilot Study Using Integrated miRNA and Gene Expression Analysis

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background and Objective Renal clear cell carcinoma (RCCC) stands out as a prevalent and aggressive subtype of kidney cancer characterized by a challenging prognosis. The need to enhance patient outcomes in RCCC underscores the significance of identifying prognostic biomarkers and therapeutic targets.
Hamed Manoochehri, Kosar Mirzaee, Amir Taherkhani, Mahmoud Gholyaf, Harleen Khatra   +4 more
wiley   +1 more source

Roles for Condensin in C. elegans Chromosome Dynamics. [PDF]

, 2011
Condensin complexes are essential for higher order organization of chromosome structure. Higher eukaryotes have two condensins (condensin I and II) dedicated to mitotic and meiotic chromosome dynamics. C. elegans was thought to be an anomaly, with only a
Collette, Karishma S.
core  

Gymnemantoside A Ameliorates Steroid‐Induced Skeletal Muscle Atrophy via Bridging Glucocorticoid and Insulin Receptor Signalling

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Skeletal muscle atrophy is a common condition caused by numerous factors, such as aging (termed sarcopenia), disease (e.g., cancer cachexia) or specific medications (such as glucocorticoids). There is no FDA‐approved drug for treating skeletal muscle atrophy.
Eun‐Jin Park, Hyun‐Jun Kim, Sang‐Hoon Lee, Seri Choi, Thi‐Phuong Doan, Kyoung‐Hwan Joo, Jin‐Pyo An, Da‐Woon Jung, Darren Reece Williams, Won Keun Oh   +9 more
wiley   +1 more source

Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus

Biology Open, 2017
After mitosis, nuclear reorganization occurs together with decondensation of mitotic chromosomes and reformation of the nuclear envelope, thereby restoring the Ran-GTP gradient between the nucleus and cytoplasm.
Keita Aoki, Hironori Niki
doaj   +1 more source