Results 91 to 100 of about 7,152 (199)

Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells. [PDF]

PLoS Genetics, 2017
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition.
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth   +9 more
doaj   +1 more source

Condensins and 3D Organization of the Interphase Nucleus [PDF]

Current Genetic Medicine Reports, 2013
Condensins are conserved multi-subunit protein complexes that participate in eukaryotic genome organization. Well known for their role in mitotic chromosome condensation, condensins have recently emerged as integral components of diverse interphase processes. Recent evidence shows that condensins are involved in chromatin organization, gene expression,
Heather A, Wallace, Giovanni, Bosco
openaire   +2 more sources

Generative Cell Division, but Not Early Nuclear Reorganization, Requires Transcriptional Reactivation During Pollen Tube Growth

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Bicellular pollen often enters a desiccated state wherein development is temporarily arrested, enabling long‐term survival while maintaining the capacity for rapid activation upon hydration. Although the generative cell in mature pollen of Lilium species is known to have completed DNA replication, its precise cell‐cycle status and the ...
Mio K. Shibuta, Aina Komatsu, Tsugumi Aso   +2 more
wiley   +1 more source

Condensin restructures chromosomes in preparation for meiotic divisions [PDF]

, 2004
The production of haploid gametes from diploid germ cells requires two rounds of meiotic chromosome segregation after one round of replication. Accurate meiotic chromosome segregation involves the remodeling of each pair of homologous chromosomes around ...
Barbara J. Meyer, Aaron F. Severson, Chan, Raymond C, Raymond C. Chan, Meyer, Barbara J, Severson, Aaron F   +5 more
core   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin, Benjamin R. Gilbert, Zaida Luthey‐Schulten   +2 more
wiley   +1 more source

Condensin and Chromatin Mediated X Chromosome Architecture in Caenorhabditis elegans. [PDF]

, 2016
Dosage compensation is an essential gene regulatory mechanism that balances X-linked gene expression and X to autosomal expression in organisms that utilize a chromosome-based method of sex determination.
Lau, Alyssa C.
core   +4 more sources

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source

Developmental expression of Ap‐Vas proteins in aphids and flies reveals their evolutionary roles in insects

Insect Molecular Biology, Volume 35, Issue 3, Page 217-231, June 2026.
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin, Szu‐Chieh Wang, Charles E. Cook, Ming‐Der Lin, Chun‐che Chang   +4 more
wiley   +1 more source

The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]

, 2012
The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P., Nathke, Inke S.; id_orcid, Ashwat Visvanathan, Daniel Klotz (158368), Inke S Näthke, Visvanathan, Ashwat, Gaganmeet S. Chadha (158365), Klotz Daniel, Swedlow, Jason R.; id_orcid, Visvanathan, A., Näthke, I.S., Chadha, Gaganmeet S., Gaganmeet S Chadha, Lamond Angus, Angus Lamond (158376), Dikovskaya Dina, Visvanathan Ashwat, Dikovskaya, Dina, Näthke Inke S., Lamond, A., Swedlow Jason R., Dina Dikovskaya (158354), Jason R. Swedlow (158382), Inke S. Näthke (158386), Newton Ian P., Lamond, Angus; id_orcid, Newton, I.P., Khoudoli, Guennadi, Khoudoli, G., Angus Lamond, Guennadi Khoudoli (158358), Dikovskaya, D., Daniel Klotz, Klotz, D., Jason R Swedlow, Khoudoli Guennadi, Chadha, G.S., Guennadi Khoudoli, Klotz, Daniel, Dina Dikovskaya, Ian P. Newton (158362), Chadha Gaganmeet S., Ashwat Visvanathan (158372), Swedlow, J.R., Ian P Newton   +44 more
core   +1 more source

Chromosome Territories Meet a Condensin

PLoS Genetics, 2012
In human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. Upon exit from mitosis, they decondense and are packed together into the nucleus, in which individual chromosomes are no longer discernible.
openaire   +4 more sources