Results 111 to 120 of about 7,152 (199)
Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans.
PLoS GeneticsDosage compensation in Caenorhabditis elegans equalizes X-linked gene expression between XX hermaphrodites and XO males. The process depends on a condensin-containing dosage compensation complex (DCC), which binds the X chromosomes in hermaphrodites to ...
Jessica Trombley +4 more
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Condensin subunits co-purify with MAP::SMCL-1.
, 2017 (A-B) Proteins that co-purified with MAP::SMCL-1 but not untagged control adult extracts, identified by tandem affinity purification and MudPIT mass spectrometry. Numbers represent average NSAF values from two replicas.
John R. Yates III (133663) +4 more
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Chromosome compaction is triggered by an autonomous DNA-binding module within condensin
Cell ReportsSummary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to ...
Alyssa Pastic +5 more
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The Journal of Cell Biology, 2002 ![][1] Condensin introduces supercoils (left) by wrapping DNA around itself (right). Hirano/Elsevier Packing DNA into a nucleus is no mean feat. Now, David Bazett-Jones (Hospital for Sick Children, Toronto, Canada), Keiji Kimura, and Tatsuya Hirano (Cold Spring Harbor Laboratory,
openaire +2 more sources
Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts [PDF]
Condensin is an essential component of chromosome dynamics, including mitotic chromosome condensation and segregation, DNA repair, and development. Genome-wide localization of condensin is known to correlate with transcriptional activity.
Nakazawa, Norihiko +2 more
core +1 more source
Phosphorylation and activation of 13S condensin by Cdc2 in vitro
, 1998 13S condensin is a multisubunit protein complex essential for mitotic chromosome condensation in Xenopus egg extracts. Purified 13S condensin introduces positive supercoils into DNA in the presence of topoisomerase I and adenosine triphosphate in vitro ...
Kobayashi, R. +3 more
core +1 more source
Molecular mechanism targeting condensin for chromosome condensation
The EMBO JournalGenomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC activity is specifically targeted ...
Menglu Wang +5 more
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The length and strength of compartmental interactions are modulated by condensin II activity.
PLoS GeneticsThe spatial organization of the genome is crucial for its function and integrity. Although the ring-like SMC complex condensin II has a well-documented role in organizing mitotic chromosomes, its function in interphase chromatin structure has remained ...
Randi Isenhart +7 more
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Oligomerization and ATP stimulate condensin-mediated DNA compaction
, 2017 Large-scale chromatin remodeling during mitosis is catalyzed by a heteropentameric enzyme known as condensin. The DNA-organizing mechanism of condensin depends on the energy of ATP hydrolysis but how this activity specifically promotes proper compaction ...
Ross A. Keenholtz +5 more
core +1 more source
Scientific ReportsCohesin and condensin, two related protein complexes, play essential roles in ensuring the accurate segregation of the genome into daughter cells during cell division. However, the interaction between cohesin and condensin in embryonic stem cells remains
Eui-Hwan Choi, Keun P. Kim
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