Results 111 to 120 of about 6,725 (195)
Chromosome compaction is triggered by an autonomous DNA-binding module within condensin
Cell ReportsSummary: The compaction of chromatin into mitotic chromosomes is essential for faithful transmission of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated by the condensin complex, though the exact mechanism used to ...
Alyssa Pastic +5 more
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The Journal of Cell Biology, 2002 ![][1] Condensin introduces supercoils (left) by wrapping DNA around itself (right). Hirano/Elsevier Packing DNA into a nucleus is no mean feat. Now, David Bazett-Jones (Hospital for Sick Children, Toronto, Canada), Keiji Kimura, and Tatsuya Hirano (Cold Spring Harbor Laboratory,
openaire +2 more sources
Condensin II interacts with BLM helicase in S phase to maintain genome stability
Communications BiologyVertebrates possess two condensins, I and II, that are essential for chromosome condensation and segregation. Condensin II has also been implicated in maintaining genome integrity outside of mitosis, though the underlying mechanisms are unclear. Here, we
Brian Rodemoyer +3 more
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Molecular mechanism targeting condensin for chromosome condensation
The EMBO JournalGenomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but how SMC activity is specifically targeted ...
Menglu Wang +5 more
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Condensin confers the longitudinal rigidity of chromosomes.
, 2015 In addition to inter-chromatid cohesion, mitotic and meiotic chromatids must have three physical properties: compaction into 'threads' roughly co-linear with their DNA sequence, intra-chromatid cohesion determining their rigidity, and a mechanism to ...
Godwin, J +12 more
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Understanding the role of condensin II in chromosome structure
, 2015 © 2015 Dr. Muhammed Adnan M. BakhrebahThe condensin complex plays a key role in organising mitotic chromosomes. In vertebrates, there are two condensin complexes that have independent and cooperative roles in folding mitotic chromosomes.
Bakhrebah, Muhammed Adnan M.
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Scientific ReportsCohesin and condensin, two related protein complexes, play essential roles in ensuring the accurate segregation of the genome into daughter cells during cell division. However, the interaction between cohesin and condensin in embryonic stem cells remains
Eui-Hwan Choi, Keun P. Kim
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An investigation into factors affecting condensin association with mitotic centromeres
, 2017 The SMC protein family (Structural Maintenance of Chromosomes) consists of a group of highly conserved protein complexes, central to chromosome dynamics and key cell cycle events.
Catrina Anne Miles (16243238)
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Nature CommunicationsNeural stem and progenitor cell (NSPC) maintenance is essential for ensuring that organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in which babies are born with significantly smaller head sizes and cortical volumes.
Bert I. Crawford +6 more
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The condensin ATPase: towards a mechanistic view of chromosome condensation [PDF]
, 2014 The central aim of cell division is the accurate transmission of replicated genetic material to daughter cells. To enable this segregation, centimetre-long DNA molecules must be organised into condensed micrometre-sized chromosomes.
Thadani, RR
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