Results 221 to 230 of about 44,698 (271)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Chimeric reference panels for genomic imputation. [PDF]

Genetics
Zhou M, James ME, Engelstädter J, Ortiz-Barrientos D.   +3 more
europepmc   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Chromosomal-level genome assembly of the autotetraploid Anoectochilus roxburghii (Jinxianlian, Orchidaceae). [PDF]

Sci Data
Fang J, Wu M, Zhang X, Chen Y, Tou L, Xu J, Kong X, Qiu Y.   +7 more
europepmc   +1 more source

Service Evaluation: Increasing Transparency in Decision‐Making and Acknowledging Professional's Feelings When Working With Gender Dysphoria in Children's Mental Health Services

Child &Family Social Work, EarlyView.
ABSTRACT There is a lack of evidence‐based guidelines for supporting young people with gender dysphoria and intellectual disability in the United Kingdom. The NHS is moving towards more care being provided by non‐specialist gender services and it is unclear what this may feel like for professionals in these services.
Laura Prodger, Alex Zouloumis, Melanie Hodgkinson, Laura Bartlett   +3 more
wiley   +1 more source

Colorectal cancer-associated <i>Streptococcus gallolyticus</i>: a hidden diversity expose. [PDF]

J Bacteriol
Périchon B, Cokelaer T, Teh WK, du Merle L, Ma L, Touchon M, Doloy A, Poyart C, Givskov M, Trieu-Cuot P, Dramsi S.   +10 more
europepmc   +1 more source

Retinal Pigment Epitheliopathy due to Sub‐Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11‐Related Phenotype

Clinical Genetics, EarlyView.
RDH11 is a minor isoenzyme that catalyses the oxidation of 11‐cis‐retinol to 11‐cis‐retinal in the retinal pigment epithelium, alongside RDH5 and RDH10. Biallelic null variants in RDH11 lead to upregulation of RDH5 and RDH10 (transcriptional adaptation), maintaining 11‐cis‐retinal bioavailability, but still causing Retinal Pigment Epitheliopathy due to
Kirk A. J. Stephenson, Zhuo Shao, Anupreet Tumber, Erika Tavares, Kashif Ahmed, Edward J. Higginbotham, Christian R. Marshall, Jason T. Maynes, Ammaji Rajala, Raju V. S. Rajala, Elise Héon, Ajoy Vincent   +11 more
wiley   +1 more source

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning

Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning
BACKGROUND: All the ruvA, ruvB and ruvC mutants of Escherichia coli are sensitive to treatments that damage DNA, and are mildly defective in homologous recombination. It has been reported that the ruv mutants form nonseptate, multinuclear filaments after low doses of UV irradiation, dependent on the sfiA gene product.
openaire  

Complete genome sequence of polyhydroxyalkanoates and carotenoid-producing <i>Paracoccus marcusii</i> strain LL1 isolated from Lonar Lake, India. [PDF]

Microbiol Resour Announc
Cabulong RB, Adigun AO, Awala SI, Jantharadej K, Sawant SS, Kim BS.   +5 more
europepmc   +1 more source

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, EarlyView.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source