Distinct architectural requirements for the parS centromeric sequence of the pSM19035 plasmid partition machinery [PDF]
eLife, 2022 Three-component ParABS partition systems ensure stable inheritance of many bacterial chromosomes and low-copy-number plasmids. ParA localizes to the nucleoid through its ATP-dependent nonspecific DNA-binding activity, whereas centromere-like parS-DNA and
Andrea Volante +2 more
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Type I partition-related proteins enhance conjugative transfer through transcriptional activation and oriT region binding [PDF]
mBioPlasmid partitioning and bacterial conjugation are critical processes ensuring plasmid maintenance and dissemination, respectively, within bacterial populations.
Kouhei Kishida +9 more
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Nonspecific DNA binding by P1 ParA determines the distribution of plasmid partition and repressor activities [PDF]
Journal of Biological Chemistry, 2020 Barbara Funnell +2 more
exaly +2 more sources
Cross-Host Adaptation of Campylobacter jejuni Is Shaped by Chromosomal Backgrounds and Mobile Gene Acquisition, with Human-Associated Traits Emerging Under Limited Mutational Diversification [PDF]
MicroorganismsCampylobacter jejuni is a major zoonotic pathogen that circulates among birds, livestock, humans, and environmental reservoirs, yet the genomic mechanisms that enable persistence and transmission across divergent hosts remain incompletely understood ...
Yingdong Li +7 more
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Frontiers in Microbiology, 2021 The ParABS partitioning system, a main driver of DNA segregation in bacteria, employs two proteins, ParA and ParB, for plasmid partition. The pMF1 plasmid from Myxococcus fulvus 124B02 has a par operon encoding a small acidic protein, ParC, in addition ...
Duohong Sheng +5 more
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eLife, 2021 ParABS partition systems, comprising the centromere-like DNA sequence parS, the parS-binding ParB-CTPase, and the nucleoid-binding ParA-ATPase, ensure faithful segregation of bacterial chromosomes and low-copy-number plasmids.
James A Taylor +4 more
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Structural analysis of the ParR/parC plasmid partition complex [PDF]
EMBO Journal, 2007 Simon Ringgaard +2 more
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Mathematical Models of Plasmid Population Dynamics
Frontiers in Microbiology, 2021 With plasmid-mediated antibiotic resistance thriving and threatening to become a serious public health problem, it is paramount to increase our understanding of the forces that enable the spread and maintenance of drug resistance genes encoded in mobile ...
José Carlos Ramón Hernández-Beltrán +3 more
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Defining the role of ATP hydrolysis in mitotic segregation of bacterial plasmids. [PDF]
PLoS Genetics, 2013 Hydrolysis of ATP by partition ATPases, although considered a key step in the segregation mechanism that assures stable inheritance of plasmids, is intrinsically very weak.
Yoan Ah-Seng +3 more
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Endogenous 2μ Plasmid Editing for Pathway Engineering in Saccharomyces cerevisiae
Frontiers in Microbiology, 2021 In Saccharomyces cerevisiae, conventional 2μ-plasmid based plasmid (pC2μ, such as pRS425) have been widely adopted in pathway engineering for multi-copy overexpression of key genes. However, the loss of partition and copy number control elements of yeast
Bo-Xuan Zeng +11 more
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