Structure of the substrate-engaged SecA-SecY protein translocation machine [PDF]
Proteins are translocated across membranes through the Sec61/SecY channel. Here, the authors present the structure of a translocating peptide chain trapped inside the SecA-SecY complex which suggests how peptides are actively moved through the channel.
Eunyong Park +2 more
exaly +4 more sources
Voltage Sensing in Bacterial Protein Translocation [PDF]
The bacterial channel SecYEG efficiently translocates both hydrophobic and hydrophilic proteins across the plasma membrane. Translocating polypeptide chains may dislodge the plug, a half helix that blocks the permeation of small molecules, from its ...
Denis G. Knyazev +5 more
doaj +3 more sources
First Report of Desmodium styracifolium as a Novel Host for ‘Candidatus Phytoplasma australasiaticum’—Related Strains in China [PDF]
Desmodium styracifolium (Osb.) Merr., a member of the Leguminosae family, is an important medicinal plant widely used in traditional Chinese medicine. In September 2024, D.
Yafei Tang +7 more
doaj +2 more sources
SecY-SecY and SecY-SecG contacts revealed by site-specific crosslinking [PDF]
Protein translocation across the cytoplasmic membrane of Escherichia coli is mediated by the integral membrane complex SecYEG and the peripherally bound ATPase SecA. To probe the environment of the cytoplasmic domains of SecY within the SecYEG complex, we introduced single cysteine residues in each of the six cytoplasmic domains.
Arnold JM Driessen
exaly +4 more sources
SECY APP: self configuration and easy management for software defined smart homes [PDF]
In this paper we address configuration and management issues of smart homes. Current platforms requires the user to deal with several management inconvenience problems, such as increasing devices, operating between devices, and using new devices.
Maselli, Gaia, Piva, Mauro
core +3 more sources
Canine Leptospirosis in Flood-Affected Areas of Southern Brazil: Molecular Assessment and Public Health Implications [PDF]
Background: Southern Brazil faced massive rains and floods in May 2024, which led to social, infrastructural, and One Health issues affecting over 478 municipalities and 2.3 million people.
Gabriela Merker Breyer +10 more
doaj +2 more sources
Protein Translocation Is Mediated by Oligomers of the SecY Complex with One SecY Copy Forming the Channel [PDF]
Many proteins are translocated across the bacterial plasma membrane by the interplay of the cytoplasmic ATPase SecA with a protein-conducting channel, formed from the evolutionarily conserved heterotrimeric SecY complex. Here, we have used purified E. coli components to address the mechanism of translocation.
Tom A Rapoport
exaly +3 more sources
Leptospirosis outbreak in Ecuador in 2023: A pilot study for surveillance from a One Health perspective [PDF]
Leptospirosis is a neglected zoonotic disease that is endemic in tropical regions, including Ecuador. It is caused by spirochetes of the genus Leptospira, which can infect humans through animal reservoirs such as rats and dogs, or through contact with ...
Solón Alberto Orlando +26 more
doaj +2 more sources
Grapevine “bois noir”, related to the presence of ‘Candidatus Phytoplasma solani’ (‘Ca. P. solani’), represents a serious threat in several vine-growing areas worldwide.
Roberto Pierro +8 more
doaj +1 more source
ObjectiveTo mine specific proteins and their protein-coding genes as suitable molecular biomarkers for the Burkholderia cepacia Complex (BCC) bacteria detection based on mega analysis of microbial proteomic and genomic data comparisons and to develop a ...
Yiling Fan +10 more
doaj +1 more source

