Results 141 to 150 of about 1,033,685 (362)

“Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”

Nature Genetics, 2015
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here we generate genome-wide maps of crossovers
C. Ottolini, Louise J. Newnham, A. Capalbo, Senthilkumar A. Natesan, Hrishikesh A. Joshi, D. Cimadomo, D. Griffin, K. Sage, M. Summers, A. Thornhill, E. Housworth, Alex D Herbert, L. Rienzi, F. Ubaldi, A. Handyside, E. Hoffmann   +15 more
semanticscholar   +1 more source

Modern and Ancient Genomes Reveal Neolithic Paternal Expansions of Millet and Rice Farmers and Demic Diffusion from China into Mainland Southeast Asia

Advanced Science, EarlyView.
This study clarifies the genetic patterns of paternal lineages across East Asia and Mainland Southeast Asia. Han populations are relatively homogeneous, whereas southern ethnolinguistic minorities display regional structures. Shared Y‐chromosome lineages indicate Neolithic expansions and extensive north‐south gene flow, supporting demic diffusion ...
Yunhui Liu, Lintao Luo, Yutong Jiang, Minzhu Zhao, Ting Yang, Zhiyong Wang, Lisiteng Luo, Yuhang Feng, Zihao Zhu, Yuzhu Wang, Limei Zhang, Bofeng Zhu, Chao Liu, Renkuan Tang, Mengge Wang, Guanglin He   +15 more
wiley   +1 more source

Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation [PDF]

, 2015
Teng Zhang, Yang Zhou, Shu‐Tao Qi, Zhen‐Bo Wang, Weiping Qian, Ying‐Chun Ouyang, Wei Shen, Heide Schatten, Qing‐Yuan Sun   +8 more
openalex   +2 more sources

Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation

eLife, 2015
The segregation of eukaryotic chromosomes during mitosis requires their extensive folding into units of manageable size for the mitotic spindle. Here, we report on how phosphorylation at serine 10 of histone H3 (H3 S10) contributes to this process. Using
Tom Kruitwagen, Annina Denoth-Lippuner, Bryan J Wilkins, Heinz Neumann, Yves Barral   +4 more
doaj   +1 more source

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

, 2002
In most aerobic organisms hemoperoxidases play a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity.
Kelly, John M, Mauricio, Isabel L, Obado, Samson O, Wilkinson, Shane R   +3 more
core   +2 more sources

Dual pathway spindle assembly increases both the speed and the fidelity of mitosis [PDF]

, 2011
Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD).
Cross, R. A., Kaseda, Kuniyoshi, McAinsh, Andrew D.   +2 more
core   +2 more sources

Genome‐Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice

Advanced Science, EarlyView.
Based on large‐scale screening of 420 rice accessions, GWAS identified the Rc locus as a key regulator of EMS mutagenesis efficiency. Functional Rc alleles enhance both seed survival and genome‐wide mutation frequency by boosting antioxidant enzyme activities (CAT, SOD, POD) and reducing oxidative damage.
Peizhou Xu, Qinglu Zhang, Le Xue, Zhen Zhang, Nanhui Luo, Zhaoyang Cheng, Duo Xia, Shuqin Zheng, Xianjun Wu, Hao Zhou   +9 more
wiley   +1 more source

Kinetochore-independent chromosome segregation driven by lateral microtubule bundles

eLife, 2015
During cell division, chromosomes attach to spindle microtubules at sites called kinetochores, and force generated at the kinetochore-microtubule interface is the main driver of chromosome movement.
C. Muscat, Keila M Torre-Santiago, Michael V. Tran, J. Powers, Sarah M. Wignall   +4 more
semanticscholar   +1 more source

Histone Marks Direct Chromosome Segregation [PDF]

Cell, 2015
Germline stem cells divide asymmetrically, producing a self-renewing stem cell and a differentiating progenitor. Xie et al. now show that this depends on two asymmetric events that together partition a genome copy, carrying the old histones to the stem cell daughter and a copy with new, unmarked histones to the differentiating daughter.
openaire   +2 more sources

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source