Results 141 to 150 of about 179,792 (368)

Non-random Mis-segregation of Human Chromosomes

open access: yesCell Reports, 2018
Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a ...
Joseph Thomas Worrall   +9 more
doaj  

UBASH3B-mediated silencing of the mitotic checkpoint: Therapeutic perspectives in cancer

open access: yesMolecular & Cellular Oncology, 2018
Defects in mitosis can lead to aneuploidy, which is a common feature of human cancers. Spindle Assembly Checkpoint (SAC) controls fidelity of chromosome segregation in mitosis to prevent aneuploidy. The ubiquitin receptor protein Ubiquitin Associated and
Ksenia Krupina   +5 more
doaj   +1 more source

Impact of crowders on the morphology of bacterial chromosomes [PDF]

open access: yesEurophysics Letters 128, 68003 (2019), 2019
Inspired by recent experiments on the effects of cytosolic crowders on the organization of bacterial chromosomes, we consider a "feather-boa" type model chromosome in the presence of non-additive crowders, encapsulated within a cylindrical cell. We observe spontaneous emergence of complementary helicity of the confined polymer and crowders.
arxiv  

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

open access: yes, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson   +33 more
core   +2 more sources

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

open access: yesAnnals of Neurology, Volume 97, Issue 6, Page 1134-1143, June 2025.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa   +24 more
wiley   +1 more source

Axial contraction and short-range compaction of chromatin synergistically promote mitotic chromosome condensation

open access: yeseLife, 2015
The segregation of eukaryotic chromosomes during mitosis requires their extensive folding into units of manageable size for the mitotic spindle. Here, we report on how phosphorylation at serine 10 of histone H3 (H3 S10) contributes to this process. Using
Tom Kruitwagen   +4 more
doaj   +1 more source

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

open access: yesAnimal Research and One Health, EarlyView.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao   +14 more
wiley   +1 more source

Protocol for studying topological DNA interactions by purified fission yeast condensin

open access: yesSTAR Protocols
Summary: To understand the transition from interphase chromatin into well-shaped chromosomes during cell divisions, we need to understand the biochemical activities of the contributing proteins.
Minzhe Tang, Frank Uhlmann
doaj  

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

open access: yesNature Communications, 2016
Aurora B activation at the centromere is critical for faithful chromosome segregation in mammals. Here the authors show that Aurora B-mediated phosphorylation of histone H2AX at serine 121 is essential for Aurora B auto-activation circuitry at ...
Midori Shimada   +9 more
doaj   +1 more source

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