Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture
International Journal of Cancer, EarlyView.Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert +3 more
wiley +1 more source
Molecular basis of ParA ATPase activation by the CTPase ParB during bacterial chromosome segregation. [PDF]
Nat CommunSchnabel L +10 more
europepmc +2 more sources
A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae. [PDF]
, 1982 John S. Wood, Leland H. Hartwell
openalex +1 more source
International Journal of Cancer, EarlyView.What's New? Using 21 SNPs, two novel PRS were constructed and used to develop two new machine‐learning classifiers, one for the detection of prostate cancer and the other for the prediction of its aggressiveness and subsequent mortality. The classifier for disease detection is built using the PRS as the sole feature, whereas the one for disease ...
Leandro Rodrigues Santiago +3 more
wiley +1 more source
RECOMBINATION AND CHROMOSOME SEGREGATION DURING THE SINGLE DIVISION MEIOSIS IN SPO12–1 AND SPO13–1 DIPLOIDS [PDF]
, 1980 Sue Klapholz, Rochelle Easton Esposito
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FIGO committee opinion: Environmental drivers of gynecologic and reproductive health
International Journal of Gynecology &Obstetrics, EarlyView.Abstract This FIGO committee opinion paper addresses the growing body of evidence linking environmental exposures to common gynecologic and reproductive conditions across the life course. From adolescence through menopause, women are exposed to a wide range of environmental toxicants, including endocrine‐disrupting chemicals, air pollutants, heavy ...
Nathaniel DeNicola +9 more
wiley +1 more source
The influence of mutations on chromosome 17 upon the segregation of homologues in female mice heterozygous for Robertsonian translocations [PDF]
, 1987 A. Ruvinsky +3 more
openalex +1 more source
FIGO committee opinion: Environmental drivers of obstetric health and early childhood development
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Environmental exposures are increasingly recognized as critical, yet underappreciated, determinants of reproductive, perinatal, and early childhood health. Developed through a structured consensus process and grounded in systematic evidence review, this FIGO committee opinion provides a comprehensive synthesis of the current evidence linking ...
Nathaniel DeNicola +12 more
wiley +1 more source
iMeta, EarlyView.The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu +15 more
wiley +1 more source
Novel mutation associated with non‐compaction ventricular myocardium: A case report
ESC Heart Failure, EarlyView.
Yan Li +4 more
wiley +1 more source