Results 191 to 200 of about 616,821 (255)

Integrated Molecular Autopsy in a Highly Consanguineous Perinatal Cohort With Severe Malformations and Strong Genetic Susceptibility

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield of integrated molecular autopsy (IMA) by combining deep post‐mortem phenotyping with exome (ES) and targeted genome sequencing (GS) for prenatally detected anomalies. Method This retrospective study evaluated 28 perinatal cases (22 fetuses, six neonates) with severe anomalies, normal first‐tier ...
Sihem Darouich, Samia Darouich, Ahmed Khemiri, Dorsaf Gtari, Raoudha Smiti, Ahmed Nhili, Houda Bellamine   +6 more
wiley   +1 more source

Mitotic Phosphorylation of Swi6/HP1 Regulates Its Chromatin Binding and Chromosome Segregation. [PDF]

FASEB J
Yoshimura Y, Hayashi A, Tanaka M, Suzuki-Matsubara M, Nakagawa R, Nishibuchi G, Tagami H, Oki M, Nakayama JI.   +8 more
europepmc   +1 more source

Comprehensive analysis of microtubule‐inhibiting herbicides reveals shared subcellular phenotypes and distinct resistance profiles

Pest Management Science, EarlyView.
Using cellular phenotyping and resistance profiling, we show that herbicides across the Herbicide Resistance Action Committee (HRAC) Groups 3 and 23 induce indistinguishable, dose‐dependent microtubule defects. Resistance patterns, rather than cellular phenotypes, reveal distinct sites of action and support reclassifying Group 3 as α‐tubulin binders ...
Katharina Kaprocki, Jennifer Blau, Michael Betz, Jessica Knox, Jens Lerchl, Philipp Johnen, Selene Garcia‐Hernandez   +6 more
wiley   +1 more source

Nucleosome interaction of the CPC secures centromeric chromatin integrity and chromosome segregation fidelity. [PDF]

EMBO J
Gireesh A, Abad MA, Nozawa RS, Sotelo-Parrilla P, Dury LC, Likhodeeva M, Wear M, Spanos C, Peralta CC, Rappsilber J, Hopfner KP, Wilson MD, Vanderlinden W, Hirota T, Jeyaprakash AA.   +14 more
europepmc   +1 more source

Identifying resistance‐conferring cytochrome P450s in weeds: experimental strategies and practical considerations

Pest Management Science, EarlyView.
Identifying resistance‐conferring cytochrome P450s requires integrating weed characterization, gene discovery and functional validation. No single approach is sufficient to distinguish causal resistance genes from herbicide‐metabolizing enzymes. Abstract Cytochrome P450 monooxygenases (P450s) play a pivotal role in metabolic herbicide resistance, yet ...
Satoshi Iwakami, Takuya Yamaguchi
wiley   +1 more source

Tankyrase activity is essential for asymmetric division and chromosome segregation in oocyte meiosis. [PDF]

J Adv Res
Lu PS, Pan ZN, Pan WL, Zou YJ, Ma RJ, Zhang KH, Wang Y, Sun SC.   +7 more
europepmc   +1 more source

Chaetocin Induces Ferroptosis in Cisplatin‐Resistant Ovarian Cancer Cells Through Neddylation‐Mediated TFRC Upregulation

Phytotherapy Research, EarlyView.
Chaetocin induces ferroptosis in cisplatin‐resistant ovarian cancer cells through neddylation‐mediated TFRC upregulation. ABSTRACT Ovarian cancer (OV) is a highly lethal gynecological tumor, often developing platinum chemotherapy resistance and treatment failure.
Hanfei Xie, Wumin Dai, Lu Sun, Wangang Gong, Tao Zhu, Yingli Zhang   +5 more
wiley   +1 more source

Chromosome Segregation in Closed Mitosis Under an Excess of Nuclear Envelope. [PDF]

Biol Cell
Rodríguez-Herrera N, Santana-Sosa S, Medina-Suárez S, Morais-Armas S, Matos-Perdomo E, Machín F.   +5 more
europepmc   +1 more source

PSMF1 Variants in a German Parkinson's Disease Cohort

Movement Disorders, EarlyView.
Carolin Gabbert, Christoph Much, Alicia Wenghöfer, André Fienemann, Susen Schaake, Theresa Lüth, Max Borsche, Norbert Brüggemann, Christine Klein, Joanne Trinh   +9 more
wiley   +1 more source

Context‐Dependent Radioenhancement by Platinum Nanoparticles Under Conventional and Ultra‐High Dose‐Rate “FLASH” Radiotherapy

Small, EarlyView.
Overview of the experimental workflow and main findings of the study investigating Pt‐NPs‐mediated radioenhancement under conventional 134 dose‐rate (CONV) and ultrahigh dose‐rate (UHDR) 9 MeV electron irradiation. Pt‐NP distribution and uptake were characterized in 4T1 spheroids and syngeneic tumor models.
Cathyanne Schott, Foutina Feghali, Marine Gerbé de Thoré, Amina Joudat, Lydia Meziani, Aashini Rajpal, Winchygn Liu, Tudor Manoliu, Farah Savina, Sandrine Lacombe, Eric Deutsch, Julie Colnot, Charlotte Robert, Erika Porcel, Pauline Maury   +14 more
wiley   +1 more source