Results 171 to 180 of about 103,612 (258)

Chromosome Segregation in Closed Mitosis Under an Excess of Nuclear Envelope. [PDF]

Biol Cell
Rodríguez-Herrera N, Santana-Sosa S, Medina-Suárez S, Morais-Armas S, Matos-Perdomo E, Machín F.   +5 more
europepmc   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, EarlyView.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation. [PDF]

Cell Rep
Joo YK, Parrado CR, Li W, Yang R, Black E, Bleichert F, Liu Y, Kabeche L.   +7 more
europepmc   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Guiseppa de Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation. [PDF]

Dev Cell
Tower CA, Manske G, Ferrell EL, Anbarci DN, Jorgensen K, Ma B, Aboelenain M, Ranjan R, Chakraborty S, Moritz L, Das A, Boiani M, Black BE, Chavez S, Marsh EE, Shikanov A, Schindler K, Chen X, Hammoud SS.   +18 more
europepmc   +1 more source

Endemic but not eroded: Genomic distinctiveness and conservation genomics of the British swallowtail butterfly (Papilio machaon britannicus)

Insect Conservation and Diversity, EarlyView.
Through whole‐genome sequencing of P. machaon populations across Europe, we demonstrate that P. m. britannicus forms a genetically distinct and isolated lineage. Demographic modelling revealed weak historical gene flow from the continent. Although P. m.
Benoit Nabholz, Eliette L. Reboud, Bérénice J. Lafon, Adam M. Cotton, Martin G. Partridge, N. Mark Collins, Fabien L. Condamine   +6 more
wiley   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Chromosome segregation errors during early embryonic development. [PDF]

Reprod Med Biol
Kyogoku H.
europepmc   +1 more source

Northern cod (Gadus morhua) movement: insights from acoustic telemetry and genomics

Journal of Fish Biology, EarlyView.
Abstract Knowledge of the timing and diversity of fish movements within a commercially exploited stock complex is required to ensure the sustainability of fisheries. Although migration can be driven by environmental factors, genomic mechanisms also play an important role in this complex life‐history trait. The northern cod (Gadus morhua) stock complex,
M. Lisette Delgado, Nicole Smith, Frederick Whoriskey, Steve Devitt, Emilie Novaczek, Corey J. Morris, Tony Kess, Ian Bradbury, Sara Iverson, Paul Bentzen, Daniel E. Ruzzante   +10 more
wiley   +1 more source