Results 191 to 200 of about 187,172 (325)

Integrating Long‐Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia

open access: yesMovement Disorders, EarlyView.
Abstract Background Although many individuals with dystonia present with features indicative of single‐gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective We assessed the value of nanopore‐based long‐read sequencing (LRS) in achieving molecular clarification of dystonic syndromes.
Ugo Sorrentino   +30 more
wiley   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi   +2 more
wiley   +1 more source

The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation. [PDF]

open access: yesCell Rep
Joo YK   +7 more
europepmc   +1 more source

Relaxation of the leaf economics spectrum within and across quaking aspen Populus tremuloides genotypes

open access: yesOikos, EarlyView.
Plant functional traits typically show strong covariation, e.g. as in the worldwide leaf economics spectrum (LES). Covariation is thought to arise from selective forces and physical constraints. However, processes shaping covariation at interspecific scales may differ from those at intraspecific scales.
Jolanta Rieksta   +5 more
wiley   +1 more source

Chromosome Segregation in Closed Mitosis Under an Excess of Nuclear Envelope. [PDF]

open access: yesBiol Cell
Rodríguez-Herrera N   +5 more
europepmc   +1 more source

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