Results 191 to 200 of about 94,426 (241)

A historical perspective on Lionel Penrose: Scientist, geneticist and dedicated opponent of eugenics

Annals of Human Genetics, EarlyView.
Abstract The paper explores Lionel Penrose's scientific work. Penrose investigated the causes of mental disorders from clinical and genetic points of view. His investigations on phenylketonuria and Down syndrome helped to demonstrate the heterogenous character of mental disorders, whose causes can range from genetic with high penetrance, to largely ...
Maria Kiladi
wiley   +1 more source

Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis. [PDF]

J Mol Cell Biol
Wu F, Akbar H, Wang C, Yuan X, Dou Z, Mullen M, Niu L, Zhang L, Zang J, Wang Z, Yao X, Song X, Liu X.   +12 more
europepmc   +1 more source

Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations

Annals of Human Genetics, EarlyView.
Abstract Introduction Southern Africa has been inhabited by hunter‐gatherers for at least 20,000 years and has received diverse immigration flows in the last 2000 years. The original inhabitants have interacted with the pastoralist migrants from Eastern Africa (∼2000 ybp), followed by the southern Bantu migration arriving some 1000 ybp, and more ...
Maria Eugenia D'Amato, Peter Ristow, Michelle Livesey, Kirsty Heynes, Nicole Huber, Claudio Bravi, Anders J. Hansen, Walther Parson   +7 more
wiley   +1 more source

Acetylation of Rec8 cohesin complexes regulates reductional chromosome segregation in meiosis. [PDF]

Life Sci Alliance
Li Z, Liu Y, Jones AW, Watanabe Y.
europepmc   +1 more source

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

Annals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

Aurora B promotes the CENP-T-CENP-W interaction to guide accurate chromosome segregation in mitosis. [PDF]

J Mol Cell Biol
Liu W, Dou Z, Wang C, Zhao G, Wu F, Wang C, Aikhionbare F, Ye M, Sedzro DM, Yang Z, Fu C, Wang Z, Gao X, Yao X, Song X, Liu X.   +15 more
europepmc   +1 more source

Decoding the Role of CDCA Genes in Breast Cancer Progression: Insights From in Silico and Functional Assay

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Investigating the diagnostic potential and functional role of CDCA genes in breast cancer. ABSTRACT Background The cell division cycle‐associated (CDCA) genes regulate key cellular processes like cell cycle progression and division. This study evaluates the diagnostic and clinical relevance of CDCA genes in breast cancer.
Yongsheng Zhao, Xiaocha Ma, Jun Zhou
wiley   +1 more source

Chromosome Segregation-1-like Gene Participates in Ferroptosis in Human Ovarian Granulosa Cells via Nucleocytoplasmic Transport. [PDF]

Antioxidants (Basel)
Hu L, Hong T, He Y, Wang H, Cao J, Pu D, Gao L, Gao C, Cui Y, Wu J, Tan R.   +10 more
europepmc   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species. [PDF]

PLoS Genet
Hockens C, Lorenzi H, Wang TT, Lei EP, Rosin LF.   +4 more
europepmc   +1 more source