Results 191 to 200 of about 1,033,685 (362)

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

open access: yesCytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos   +5 more
wiley   +1 more source

Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez   +4 more
wiley   +1 more source

Knockdown of CENH3 in Arabidopsis reduces mitotic divisions and causes sterility by disturbed meiotic chromosome segregation [PDF]

open access: bronze, 2011
Inna Lermontová   +7 more
openalex   +1 more source

Reviewing Research on Transgender and Nonbinary People in Social Psychology: Insights and Future Research Directions

open access: yesEuropean Journal of Social Psychology, EarlyView.
ABSTRACT Transgender and nonbinary (TGNB) identities and issues faced by TGNB people are receiving growing attention in social psychology. At the same time, this is a relatively new area, and most research on LGBTQ+ issues primarily focuses on sexual minorities, whereas most research on gender focuses on women and men.
Thekla Morgenroth, Kira Kay Means
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

open access: yesEpilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola   +3 more
wiley   +1 more source

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