Results 201 to 210 of about 94,426 (241)

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility

Andrology, EarlyView.
Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer, Ann‐Kristin Dicke, Frank Tüttelmann   +2 more
wiley   +1 more source

Fission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity. [PDF]

MicroPubl Biol
Chaba Z, Jain I, Tran PT.
europepmc   +1 more source

Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience

Andrology, EarlyView.
Abstract Background Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.
Manon S. Oud, Nicole de Leeuw, Dominique F. C. M. Smeets, Liliana Ramos, Godfried W. van der Heijden, Raoul G. J. Timmermans, Maartje van de Vorst, Tom Hofste, Marlies J. E. Kempers, Marijn F. Stokman, Kathleen W. M. D'Hauwers, Brigitte H. W. Faas, Dineke Westra   +12 more
wiley   +1 more source

SUMOylation is enriched in the nuclear matrix and required for chromosome segregation. [PDF]

J Biol Chem
Chen Z, Luo J, Zhang Y, Zheng S, Zhang H, Huang Y, Wong J, Li J.   +7 more
europepmc   +1 more source

EP300‐interacting inhibitor of differentiation 3 is required for spermatogenesis in mice

Andrology, EarlyView.
Abstract Background Mammalian spermatogenesis is a highly complex process of cell proliferation, meiosis, and differentiation. A series of genes are expressed in an orderly and precise manner to ensure spermatogenesis, with chromatin undergoing intricate changes throughout.
Ping Zhang, Longsheng Zhang, Li Yu, Xinli Zhou, Xu Chen, Yuchuan Zhou, Ningling Wang, Hui Zhu   +7 more
wiley   +1 more source

Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells. [PDF]

J Cell Biol
Chen YL, Jones AN, Crawford A, Sattler M, Ettinger A, Torres-Padilla ME.   +5 more
europepmc   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

The spindle protein CKAP2 regulates microtubule dynamics and ensures faithful chromosome segregation. [PDF]

Proc Natl Acad Sci U S A
Paim LMG, Lopez-Jauregui AA, McAlear TS, Bechstedt S.   +3 more
europepmc   +1 more source

What do measures of gender identity tell us about gender identity over time?

British Journal of Developmental Psychology, EarlyView.
Abstract Gender identity is a multifaceted concept and is represented by a wide range of measures and constructs including both self‐report and researcher observations of preferences and behaviours. However, despite their similar theoretical underpinning, gender identity measures are rarely found to correlate with one another, and contrasting patterns ...
Ellena Fisher, Sarah Wright, Cora Sargeant   +2 more
wiley   +1 more source

Mutations in tyrosyl-DNA phosphodiesterase 2 suppress top-2 induced chromosome segregation defects during Caenorhabditis elegans spermatogenesis. [PDF]

J Biol Chem
Kwah JK, Bhandari N, Rourke C, Gassaway G, Jaramillo-Lambert A.   +4 more
europepmc   +1 more source