Results 301 to 310 of about 180,127 (346)

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

open access: yesThe FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li   +7 more
wiley   +1 more source

SUMOylation is enriched in the nuclear matrix and required for chromosome segregation. [PDF]

open access: yesJ Biol Chem
Chen Z   +7 more
europepmc   +1 more source

Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic stem cells. [PDF]

open access: yesJ Cell Biol
Chen YL   +5 more
europepmc   +1 more source

Mechanisms for chromosome segregation

Current Opinion in Microbiology, 2014
Bacteria face the problem of segregating their gigantic chromosomes without a segregation period restricted in time and space, as Eukaryotes do. Segregation thus involves multiple activities, general or specific of a chromosome region and differentially controlled. Recent advances show that these various mechanisms conform to a “pair and release” rule,
Mathieu Stouf   +5 more
openaire   +5 more sources

Bacterial Chromosome Segregation

Annual Review of Microbiology, 2002
▪ Abstract  Recent studies have made great strides toward our understanding of the mechanisms of microbial chromosome segregation and partitioning. This review first describes the mechanisms that function to segregate newly replicated chromosomes, generating daughter molecules that are viable substrates for partitioning.
James W. Gober, Geoffrey C. Draper
openaire   +3 more sources

CHROMOSOME SEGREGATION IN YEAST

Annual Review of Microbiology, 1993
Because of their genetic tractability, much has been learned concerning the mechanisms of chromosome segregation in budding yeast, Saccharomyces cerevisiae, and fission yeast, Schizosaccharomyces pombe. This chapter reviews the cytology and molecular and cell biology of mitosis in both of these yeasts.
Michael Snyder, Barbara D. Page
openaire   +3 more sources

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