Results 21 to 30 of about 84,108 (228)

Identification of candidate genes for dyslexia susceptibility on chromosome 18 [PDF]

, 2010
Background: Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage.
Olson, R K, Pennington Bruce F., Anthony P. Monaco, Pennington, B F, Scerri, TS, Alex J. Richardson, Smith, SD, Talcott, J, Richard K. Olson, Alex J Richardson, MacPhie, I L, Joel Talcott, Bruce F Pennington, Stein, J, Monaco, AP, Morris Andrew, Pennington, BF, Olson Richard K., Silvia Paracchini, Macphie, IL, DeFries, J C, Anthony P Monaco, Thomas S Scerri, Smith, Shelley D., Richardson, Alex J., Olson, RK, I Laurence MacPhie, Stein, John, Shelley D. Smith, Pennington, Bruce F., Monaco, Anthony P., Defries, JC, Paracchini, Silvia, John Stein, Stein, John F., Scerri Thomas S., MacPhie I. Laurence, Talcott, Joel B., I. Laurence MacPhie, Richardson, Alexandra, Monaco, Anthony, Andrew Morris, John C. DeFries, Talcott Joel, Morris, Andrew, Smith, S D, Smith Shelley D., Talcott, Joel, Bruce F. Pennington, Monaco Anthony P., Olson, Richard K., MacPhie, I. Laurence, Morris, A, Richardson, AJ, Paracchini, S, DeFries, John C., DeFries John C., Shelley D Smith, Stein John, John C DeFries, Monaco, A P, Richard K Olson, Paracchini Silvia, Thomas S. Scerri, Scerri, Thomas S., Scerri, T S   +65 more
core   +2 more sources

Patterns of selective constraints in noncoding DNA of rice [PDF]

, 2007
Background Several studies have investigated the relationships between selective constraints in introns and their length, GC content and location within genes. To date, however, no such investigation has been done in plants.
Peter D Keightley, Fan Longjiang, Wang, Y, Wang Yu, Guo, X, Fan, L, Longjiang Fan, Keightley Peter D, Keightley, Peter, Yu Wang, Guo Xingyi, Xingyi Guo   +11 more
core   +1 more source

Clinical, Histopathological, and Molecular Characterization of Pediatric MN1::ZNF341‐Associated Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A lethal round‐cell malignancy with an MN1::ZNF341 fusion has recently been reported in three infants. Here, we describe four further tumors, three in newborns (including monozygotic twins), and one in an adolescent. Detailed clinical, radiological, and histopathological data differentiate these tumors from their main mimics, neuroblastoma and
Thomas R. W. Oliver, Dyanne Rampling, Barbara Walkowiak, Nathaniel D. Anderson, Manas Dave, Henry Lee‐Six, Sadie Baskind, Pooja Balasubramanian, Glenn Anderson, Conor Parks, Toochi Ogbonnah, Emilia R. Robertson, Simon Hannam, Rohan Verma, John C. Achermann, Liina Palm, Neil Sebire, Thomas Jacques, Tom Watson, Carryl Dryden, Karin Straathof, Mette Jorgensen, Olga Slater, Sam Behjati, Sarita Depani, J. Ciaran Hutchinson   +25 more
wiley   +1 more source

Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline [PDF]

, 2011
A variety of mutational mechanisms shape the dynamic architecture of human genomes and occasionally result in congenital defects and disease. Here, we used genome-wide long mate-pair sequencing to systematically screen for inherited and de novo ...
Cuppen, E., Nesselrooij van, B., Roosmalen van, M., Letteboer, T., Poot, M., Hochstenbach, R., Duran, K.J., Bakker, S., van Nesselrooij, B., van Roosmalen, M., Bruijn de, E., Guryev, V., de Bruijn, E., Kloosterman, W.P.   +13 more
core   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensisn l-converting enzyme (ACE) unlinked to the ACE gene [PDF]

, 2008
Background: angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on ...
Amy Luke, Zhu, Xiaofeng, Xiaofeng Zhu, Terrence E Forrester, Forrester, Terrence E., Nourdine Bouzekri, Cooper, Richard S., Bouzekri Nourdine, Colin A McKenzie, McKenzie, Coiln A., Forrester Terrence E, Zhu Xiaofeng, McKenzie Colin A, Adeyemo, Adebowale A., Luke Amy, Bouzekri, Nourdine, Cooper Richard S, Richard S Cooper, Luke, Amy, Adebowale A Adeyemo, Adeyemo Adebowale A   +20 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

How to halve ploidy : lessons from budding yeast meiosis [PDF]

, 2012
Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Kerr, Gary W., Kerr, Gary, Sarkar, Sourav, Arumugam, Prakash   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Orphan CpG islands identify numerous conserved promoters in the mammalian genome [PDF]

, 2010
This work was funded by grants from the Wellcome Trust (077224; http://www.wellcome.ac.uk/) and the Medical Research Council (G0800026; http:// www.mrc.ac.uk/index.htm).CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of ...
Gruenewald-Schneider, Ulrike, Shaun Webb, Bird, A.P.; id_orcid, Webb, Shaun, Smith Colin, Kerr, A.R.W., Andrews, Robert, Keith D James, Daniel J. Turner, Turner, D.J., Webb, S., James, Keith D., James, K.D., Robert S Illingworth, Robert Andrews, Webb Shaun, Smith, Colin; id_orcid, Keith D. James, Harrison David J., David J. Harrison, Alastair R. W. Kerr, Bird, Adrian P., Gruenewald-Schneider, U., Gruenewald-Schneider Ulrike, Turner Daniel J., Andrews, R., Smith, Colin, Illingworth Robert S., Turner, Daniel J., Illingworth, Robert S., Ulrike Gruenewald-Schneider, David J Harrison, Bird Adrian P., Robert S. Illingworth, Alastair R W Kerr, Colin Smith, Andrews Robert, Kerr, Alastair R. W., Illingworth, R.S., Kerr Alastair R. W., Harrison, D.J., Daniel J Turner, James Keith D., Adrian P. Bird, Harrison, David J., Adrian P Bird   +45 more
core   +1 more source