Results 201 to 210 of about 1,419,260 (349)

Steps in the evolution of heteromorphic sex chromosomes

Heredity, 2005
D. Charlesworth, B. Charlesworth, G. Marais, G. Marais   +3 more
semanticscholar   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Emergence of satellite DNAs suggests centromeric repositioning as a driver of karyotypic variation of the freshwater darter characines (Apareiodon affinis). [PDF]

Chromosome Res
Ribas MS, Azambuja M, Nogaroto V, Vicari MR.   +3 more
europepmc   +1 more source

Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.

Cell, 2014
Y. Q. S. Soh, Jessica Alföldi, Tatyana Pyntikova, Laura G. Brown, Laura G. Brown, Tina Graves, P. Minx, R. Fulton, Colin L. Kremitzki, Natalia Koutseva, Jacob L. Mueller, S. Rozen, Jennifer F. Hughes, E. Owens, J. Womack, W. Murphy, Q. Cao, P. Jong, W. Warren, R. Wilson, H. Skaletsky, H. Skaletsky, David L. Page, David L. Page   +23 more
semanticscholar   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

The transfer of 98% of the genome of Aegilops mutica into wheat (Triticum aestivum). [PDF]

Theor Appl Genet
King J, Grewal S, Yang C, Scholefield D, Ashling S, Othmeni M, Hawkins K, King IP.   +7 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Genomic introgressions from wild relatives in the wheat genome alter meiotic dynamics in inter-varietal hybrids. [PDF]

Plant J
Yan L, Chéron F, Nadaud I, Hao M, Liu D, Sourdille P.   +5 more
europepmc   +1 more source

SEX CHROMOSOMES AND THE EVOLUTION OF SEXUAL DIMORPHISM

Evolution; international journal of organic evolution, 1984
W. Rice
semanticscholar   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source