Results 251 to 260 of about 1,562,582 (397)

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Complex evolutionary trajectories of sex chromosomes across bird taxa

Science, 2014
Qi Zhou, Jilin Zhang, D. Bachtrog, Na An, Quanfei Huang, E. Jarvis, M. Gilbert, Guojie Zhang   +7 more
semanticscholar   +1 more source

Non-Canonical Male Meiosis in a Marine Gastropod, <i>Littorina saxatilis</i>. [PDF]

Biology (Basel)
Demin SI, Mikhailova NA, Granovitch AI, Bogolyubov DS.   +3 more
europepmc   +1 more source

Cdk phosphorylation licenses Kif4A chromosome localization required for early mitotic progression [PDF]

, 2018
Zhixiong Dong, Changjun Zhu, Qimin Zhan, Wei Jiang   +3 more
openalex   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

Drivers of achiasmatic meiosis: sexual antagonism versus heteromorphy-dependent aneuploidy across sex-chromosome divergence. [PDF]

G3 (Bethesda)
Barboza A, Blackmon H.
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Steps in the evolution of heteromorphic sex chromosomes

Heredity, 2005
D. Charlesworth, B. Charlesworth, Gabriel A. B. Marais, Gabriel A. B. Marais   +3 more
semanticscholar   +1 more source

Crossover interference mediates multiscale patterning along meiotic chromosomes. [PDF]

Nat Commun
White MA, Weiner B, Chu L, Lim G, Prentiss M, Kleckner N.   +5 more
europepmc   +1 more source

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma [PDF]

, 2019
Alexandra McAleenan, Hayley E. Jones, Ashleigh Kernohan, Claire Faulkner, Abigail Palmer, Sarah Dawson, Christopher Wragg, Sarah Jefferies, Sebastian Brandner, Luke Vale, Julian P. T. Higgins, Kathreena M. Kurian   +11 more
openalex   +1 more source