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Carlos Chagas Discoveries as a Drop Back to Scientific Construction of Chronic Chagas Heart Disease [PDF]
Arquivos Brasileiros de Cardiologia, 2016 The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart ...
Reinaldo B. Bestetti +2 more
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Plasma-Derived Extracellular Vesicles as Potential Biomarkers in Heart Transplant Patient with Chronic Chagas Disease [PDF]
Emerging Infectious Diseases, 2020 Chagas disease is emerging in countries to which it is not endemic. Biomarkers for earlier therapeutic response assessment in patients with chronic Chagas disease are needed.
Nuria Cortes-Serra +11 more
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Effects of MK-886, an inhibitor of the 5-lipoxygenase-activating protein, on peripheral blood mononuclear cells from patients with Chagas' heart disease [PDF]
Revista da Sociedade Brasileira de Medicina TropicalBackground: Chagas disease, caused by Trypanosoma cruzi, remains a major public health challenge in Latin America. Lipid mediators, including leukotrienes, play a key role in modulating the immune response during infection.
Wanessa Maria dos Santos +10 more
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Insights from the use of erythropoietin in experimental Chagas disease
International Journal for Parasitology: Drugs and Drug Resistance, 2022 In addition to the long-established role in erythropoiesis, erythropoietin (Epo) has protective functions in a variety of tissues, including the heart. This is the most affected organ in chronic Chagas disease, caused by the protozoan Trypanosoma cruzi ...
Ana Carolina de Castro Nobre +9 more
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Memorias do Instituto Oswaldo Cruz, 2009 Among the pathophysiological derangements operating in the chronic phase of Chagas disease, parasite persistence is likely to constitute the main mechanism of myocardial injury in patients with chronic chagasic cardiomyopathy. The presence of Trypanosoma
J Antonio Marin-Neto +4 more
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PLoS ONE, 2020 BackgroundThe specific roles of parasite characteristics and immunological factors of the host in Chagas disease progression and prognosis are still under debate.
Marco Antonio Prates Nielebock +9 more
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Memorias do Instituto Oswaldo Cruz, 2007 A case-control study on chronic Chagas heart disease (CCHD) was carried out between 1997 and 2005. Ninety patients over 50 years of age were examined for factors related to (CCHD).
Silvana de Araújo Silva +2 more
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A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial
Trials, 2018 Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanisms of death in Chagas heart disease.
Marcelo Teixeira Holanda +24 more
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Frontiers in Microbiology, 2018 Chagas cardiomyopathy is the most severe clinical manifestation of chronic Chagas disease. The disease affects most of the Latin American countries, being considered one of the leading causes of morbidity and death in the continent.
Leandra Linhares-Lacerda +14 more
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Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/"indeterminate" and Chagas disease cardiomyopathy patients [PDF]
Memorias do Instituto Oswaldo Cruz, 2003 We compared plasma tumor necrosis factor-alpha (TNF-alpha) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy
Renata Cristina Ferreira +6 more
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