Results 71 to 80 of about 391,206 (279)

Chai Hu oral liquid enhances the immune functions of both spleen and bursa of Fabricius in heat-stressed broilers through strengthening TLR4-TBK1 signaling pathway

Poultry Science, 2021
: Heat stress can affect the poultry production and immune status of broilers. Heat stress disrupts intestinal integrity and increases intestinal inflammation, which is related with body immune dysfunction.
Lu-Ping Tang, Yi-Lei Liu, Kang-Ning Ding, Xiao-Jiao Hou, Jun-Jie Qin, Yi-An Zhang, Han-Xiao Liu, Xing-Ling Shen, Yong-Ming He   +8 more
doaj   +1 more source

Resveratrol mitigates hypercholesterolemia exacerbated hyperthermia in chronically heat-stressed rats

Veterinary World, 2019
Background and Aim: Hypercholesterolemia (HC) is the major leading cause of cardiovascular disease worldwide. Such atherogenic aberration deeply impacts blood circulation. Resveratrol (R) is a polyphenol that has received attention as a hypolipidemic, antioxidant, and vascular agility advocate.
Hosam Al-Tamimi, Amani Al-Dawood, Saddam Awaishesh, Tony Abdalla   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Heat stress in chickens induces temporal changes in the cecal microbiome concomitant with host enteric serotonin responses

Poultry Science
Heat stress is a potent modulator of the avian neuroendocrine system with concomitant impact on the gut microbiome. As an interkingdom signaling molecule, serotonin is largely derived from the gut and found in large concentrations in the avian gut lumen.
Joshua M. Lyte, Xinglin Jia, Valentina Caputi, Danyang Zhang, Karrie M. Daniels, Gregory J. Phillips, Mark Lyte   +6 more
doaj   +1 more source

Blood Biochemistry and Plasma Corticosterone Concentration in Broiler Chickens Under Heat Stress

Revista de Medicina Veterinaria, 2014
High ambient temperatures cause susceptibility to heat stress in broiler chickens, generating metabolic changes. This paper seeks to determine the changes in blood biochemistry and plasma corticosterone concentration, as well as in glucose, total protein,
Elvis Alexander Díaz López, Luis Fernando Uribe Velásquez, William Narváez Solarte   +2 more
doaj   +1 more source

Threshold temperatures for subjective heat stress in urban apartments—Analysing nocturnal bedroom temperatures during a heat wave in Germany

Climate Risk Management, 2021
As climate change progresses, it is causing more frequent and severe heat waves, resulting in higher indoor temperatures. Various temperature thresholds for indicating indoor overheating have been proposed in different contexts, extending from reduced ...
Sabrina Katharina Beckmann, Michael Hiete, Christoph Beck   +2 more
doaj   +1 more source

Polymorphisms of Bovine HSP90 and Their Implications in Beef Cattle Productivity [PDF]

, 2018
Production of beef cattle represents a $60 billion industry in the United States (USDA, 2015). The American beef cattle industry loses an estimated $370 million annually due to heat stress (St-Pierre, 2003).
Smith, Glynn G
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Chronic prenatal heat stress alters growth, carcass composition, and physiological response of growing pigs subjected to postnatal heat stress

Journal of Animal Science, 2020
Abstract Postnatal heat stress (HS) effects on pig physiology and performance are widely studied but prenatal HS studies, albeit increasing, are still limited. The objective of this study was to evaluate the chronic prenatal HS effects in growing pigs raised in postnatal thermoneutral (TN) or in HS environment.
Serviento, Aira Maye, Lebret, Bénédicte, Renaudeau, David   +2 more
openaire   +4 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source