Results 81 to 90 of about 391,206 (279)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases

, 2008
Cellular networks undergo rearrangements during stress and diseases. In un-stressed state the yeast protein-protein interaction network (interactome) is highly compact, and the centrally organized modules have a large overlap.
Albanese, Albert, Almaas, Arita, Barabasi, Barabasi, Batada, Batada, Batagelj, Bertin, Bobula, Colizza, Csermely, Csermely, Csermely, Csermely, Derenyi, Ekman, Gasch, Goldberger, Guimerá, Han, Kim, Komurov, Korcsmaros, Korcsmáros, Lewandowska, Linding, Luscombe, Macario, Maslov, McAuley, McClellan, Ng, Palla, Papp, Pál, Ravasz, Rutherford, Sales-Pardo, Shorter, Song, Soti, Soti, Soti, Szabadkai, Szalay, Tanaka, Taxis, Vigh, Wang, Watts, Xu, Yu, Zhu   +54 more
core   +2 more sources

Microbial lysate upregulates host oxytocin [PDF]

, 2017
Neuropeptide hormone oxytocin has roles in social bonding, energy metabolism, and wound healing contributing to good physical, mental and social health. It was previously shown that feeding of a human commensal microbe Lactobacillus reuteri (L.
Alm, Eric J., Cheung, Harry K., DiBenedictis, Brett T., Didyk, Eliska, Erdman, Susan E., Hardas, Alexandros, Ibrahim, Yassin, Kolandaivelu, Kumaran, Levkovich, Tatiana, Poutahidis, Theofilos, Ricciardi, Catherine E., Shikhman, Lana, Varian, Bernard J., Veenema, Alexa H.   +13 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

An Assessment of the Impact of Climate Change on Human Health in New Hampshire [PDF]

, 2014
Climate change threatens human health in many ways. The negative impacts of climate change on human health are likely to increase in both magnitude and frequency as the climate continues to change in response to ever increasing global emissions of heat ...
Aytur, Semra, Bucci, John, Wake, Cameron P.   +2 more
core   +2 more sources

Taurine Reduces Heat Stress by Regulating the Expression of Heat Shock Proteins in Broilers Exposed to Chronic Heat [PDF]

Brazilian Journal of Poultry Science, 2018
ABSTRACT The aim of the current study was to investigate the effects of taurine on heat stress by evaluating them RNA and protein expressions of HSP90, 70 and 60in Ross broilers. Birds were distributed in a control group (CO) reared at 24ºC, a heat-stress group (HS) maintained at 34°C (weeks 3-5) and not supplemented with taurine, and a heat-stress ...
Belal, SA, Kang, DR, Cho, ESR, Park, GH, Shim, KS   +4 more
openaire   +4 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Data on mitochondrial respiratory function in skeletal muscle of adult male mice in response to 3-weeks heat stress

Data in Brief
Chronic heat stress induces mitochondrial adaptation in skeletal muscle. However, the effect of chronic heat stress on the respiratory function per mitochondria in skeletal muscle has not been well studied.
Rikuhide Koma, Tatsuki Matsumoto, Ayaka Yamazaki, Tsubasa Shibaguchi, Thomas Jue, Kazumi Masuda   +5 more
doaj   +1 more source

Heat Stress and feeding strategies in meat-type chickens [PDF]

, 2011
Heat stress can induce hyperthermia in poultry. A reduction in heat load can be achieved by increasing the possibilities for dissipation, decreasing the level of heat production or by changing the thermal production pattern within a day.
Kwakkel, R.P., Syafwan, W., Verstegen, M.W.A.   +2 more
core   +3 more sources

Chronic Heat Stress and Respiratory Alkalosis: Occurrence and Treatment in Broiler Chicks

Poultry Science, 1985
The occurrence of respiratory alkalosis and potential benefit derived from treatment were examined in thermostressed 4-week-old broiler chicks. Blood pH was greater (P less than .05) in heat-stressed (32 C) panting birds (7.395) than either nonpanting (7.28) or birds raised at 24 C (7.28).
R G, Teeter, M O, Smith, F N, Owens, S C, Arp, S, Sangiah, J E, Breazile   +5 more
openaire   +2 more sources