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Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure [PDF]

Viruses
Chronic hepatitis B (CHB) remains a major global health challenge, largely due to the persistence of covalently closed circular DNA (cccDNA) and impaired host immunity.
Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen   +3 more
doaj   +2 more sources

The Circulating miRNA Profile of Chronic Hepatitis D and B Patients Is Comparable but Differs from That of Individuals with HBeAg-Negative HBV Infection

Viruses, 2023
miRNAs circulating in whole serum and HBsAg-particles are differentially expressed in chronic hepatitis B (CHB) and HBeAg-negative-HBV infection (ENI); their profiles are unknown in chronic hepatitis D (CHD).
Daniela Cavallone, Eric David B. Ornos, Gabriele Ricco, Filippo Oliveri, Barbara Coco, Piero Colombatto, Laura De Rosa, Leslie Michelle M. Dalmacio, Ferruccio Bonino, Maurizia Rossana Brunetto   +9 more
doaj   +1 more source

The global hepatitis delta virus (HDV) epidemic: what gaps to address in order to mount a public health response?

Archives of Public Health, 2021
Background Co-infection between hepatitis B virus (HBV) and hepatitis delta virus (HDV) causes the severest chronic hepatitis and is associated with a high risk of cirrhosis and hepatocellular carcinoma (HCC).
Tomoyuki Hayashi, Yumie Takeshita, Yvan J.-F. Hutin, Hande Harmanci, Philippa Easterbrook, Sarah Hess, Judith van Holten, Ena Oghenekaro Oru, Shuichi Kaneko, Cihan Yurdaydin, Marc Bulterys   +10 more
doaj   +1 more source

Management and Treatment of Patients with Chronic Hepatitis B: Towards Personalized Medicine

Viruses, 2022
The currently available antiviral treatments (Peg-Interferon-α and Nucleos(t)ide Analogues, NA) for chronic hepatitis B (CHB) achieve a functional cure (serum HBsAg and HDV-DNA clearance) of HBV infection in a limited number of patients.
Piero Colombatto, Barbara Coco, Ferruccio Bonino, Maurizia R. Brunetto   +3 more
doaj   +1 more source

OBESITY AND DYSLIPIDEMIA IN CHILDREN WITH CHRONIC HEPATITIS [PDF]

Romanian Journal of Pediatrics, 2016
Chronic hepatitis association with various types of dyslipidemia is a reality not only for the obese pediatric patient, in which we expect to find hypercholesterolemia and / or hypertriglyceridemias, but also for normal weight children with hepatitis ...
Alice N. Azoicai, Bogdan A. Stana, Paula Popovici, Ileana K. Ioniuc, Monica M. Alexoae, Irina Criscov, Alina M. Murgu, Evelina Moraru   +7 more
doaj   +1 more source

Different profiles of neurocognitive impairment in patients with hepatitis B and C virus infections

Scientific Reports, 2022
The direct impact of chronic hepatitis B and hepatitis C on neurocognition remains elusive due to the frequent comorbidities, and the domains of the neurocognitive functions affected have rarely been investigated comprehensively.
Chun-Hsiang Tan, Meng-Chia Chang, Wei-Fang Tsai, Wan-Long Chuang, Jee-Fu Huang, Zu-Yau Lin, Chia-Yen Dai, Ming-Lun Yeh, Chi-Ting Li, Rwei-Ling Yu   +9 more
doaj   +1 more source

Viruses and miRNAs: More Friends than Foes

Frontiers in Microbiology, 2017
There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses.
Patrice Bruscella, Silvia Bottini, Camille Baudesson, Jean-Michel Pawlotsky, Cyrille Feray, Michele Trabucchi   +5 more
doaj   +1 more source

The evaluation of liver fibrosis regression in chronic hepatitis C patients after the treatment with direct-acting antiviral agents – A review of the literature [PDF]

, 2019
The second-generation of direct-acting antiviral agents are the current treatment for chronic viral hepatitis C infection. To evaluate the regression of liver fibrosis in patients receiving this therapy, liver biopsy remains the most accurate method, but
Alexescu, Teodora G, Cibu, Bianca A, Ciulei, George, Coste, Sorina C, Cozma, Angela, Mureșan, Flaviu, Negrean, Vasile, Orasan, Olga H, Ovidiu, Fabian, Pfingstgraf, Iulia O, Popovici, Ionela E, Tarmure, Simina F, Taut, Adela V. S   +12 more
core   +3 more sources

ETIOLOGICAL CHARACTERISTICS OF CHRONIC VIRAL HEPATITIS IN THE KHOREZM REGION OF UZBEKISTAN

Байкальский медицинский журнал, 2023
A study of the etiological structure of chronic viral hepatitis is presented, taking into account the assessment of the stage of the pathological process and the genotypic affiliation of pathogens in the Khorezm region of the Republic of Uzbekistan.
Shavkat R. Yusupov, Kurban A. Aitov, Evgeny D. Savilov, Dilfuza K. Abdullayeva, Safar E. Umirov   +4 more
doaj   +1 more source

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C [PDF]

, 2012
Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Badenhoop, Klaus, Berg, Thomas, Bibert, Stephanie, Bochud, Pierre-Yves, Bojunga, Jörg, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean-François, Geier, Andreas, Gerlach, Tilman J, Heim, Markus H, Kutalik, Zoltan, Lange, Christian M, Malinverni, Raffaele, Moradpour, Darius, Müller, Tobias, Negro, Francesco, Regenass, Stephan, Sarrazin, Christoph, Swiss Hepatitis C Cohort Study Group,, Zeuzem, Stefan   +20 more
core   +4 more sources