Results 31 to 40 of about 1,217,029 (160)

A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive and metabolic dysfunctions, including gut microbiome dysbiosis.
Fereshteh Esfandiarinezhad, Xiaoshu Zhan, Seang Lin Tan, Julang Li, Benjamin K. Tsang   +4 more
doaj   +1 more source

Platelets in chronic liver disease, from bench to bedside

JHEP Reports, 2019
Summary: In the last decade, numerous studies revealed physiologic and pathophysiologic roles of platelets beyond haemostasis, a process to prevent and stop bleeding.
Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder   +3 more
doaj   +1 more source

Global DNA methylation signatures associated with chemoresistance and poor prognosis of high grade serous ovarian cancer

Scientific Reports
Ovarian cancer (OVCA) is third most lethal gynecologic cancers and acquired chemoresistance is the key link in the high mortality rate of OVCA patients. Currently, there are no reliable methods to predict chemoresistance in OVCA.
Hafiza Bushra Manzoor, Melisa Acun, Hamed Yasavoli-Sharahi, Chantal Matar, Arvind Mer, Benjamin K. Tsang, Meshach Asare-Werehene   +6 more
doaj   +1 more source

Chronic inflammation and asthma

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010
Allergic asthma is a complex and chronic inflammatory disorder which is associated with airway hyper-responsiveness and tissue remodelling of the airway structure. Although originally thought to be a Th2-driven inflammatory response to inhaled innocuous allergen, the immune response in asthma is now considered highly heterogeneous.
Murdoch, Jenna R., Lloyd, Clare M.
openaire   +3 more sources

Minibioreactor arrays to model microbiome response to alcohol and tryptophan in the context of alcohol-associated liver disease

npj Biofilms and Microbiomes
The intestinal microbiota (IM) plays a role in the severity of alcohol-associated liver disease. Modifying severe alcohol-associated hepatitis (AH) dysbiosis improves liver injury through tryptophan (Trp) metabolites and the aryl hydrocarbon receptor ...
Wanchao Hu, Sabrine Naimi, Nicolas Trainel, Vanessa Liévin-Le Moal, Gabriel Perlemuter, Benoit Chassaing, Dragos Ciocan, Anne-Marie Cassard   +7 more
doaj   +1 more source

Engineered spermidine-secreting Saccharomyces boulardii enhances olfactory memory in Drosophila melanogaster

Frontiers in Neuroscience
IntroductionThe polyamines putrescine, spermidine, and spermine are ubiquitous metabolites synthesized in all cells. The intracellular levels of polyamines, especially spermidine, decrease in aging.
Florance Parweez, Florance Parweez, Roger Palou, Ruizhen Li, Lanna Kadhim, Heath MacMillan, Mike Tyers, Mike Tyers, X. Johné Liu, X. Johné Liu, X. Johné Liu   +10 more
doaj   +1 more source

Dietary Emulsifiers Directly Impact Adherent-Invasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation

Cell Reports, 2020
Summary: Dietary emulsifiers carboxymethylcellulose (CMC) and polysorbate-80 (P80) disturb gut microbiota, promoting chronic inflammation. Mice with minimal microbiota are protected against emulsifiers’ effects, leading us to hypothesize that these ...
Emilie Viennois, Alexis Bretin, Philip E. Dubé, Alexander C. Maue, Charlène J.G. Dauriat, Nicolas Barnich, Andrew T. Gewirtz, Benoit Chassaing   +7 more
doaj   +1 more source

Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie,
Nicole L. Mancini, Luke Goudie, Warren Xu, Rasha Sabouny, Sruthi Rajeev, Arthur Wang, Nicolas Esquerre, Ala Al Rajabi, Timothy S. Jayme, Erik van Tilburg Bernandes, Yasmin Nasser, José G.P. Ferraz, Timothy Shutt, Jane Shearer, Derek M. McKay   +14 more
doaj   +1 more source

GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease

Cell Death and Disease
Intestinal cell death is a defining feature of Crohn’s disease (CD), a major form of inflammatory bowel disease. The focus on this aspect of enteric inflammation has mainly been on epithelial cells, while other cell types such as stromal and myeloid ...
James A. Sousa, Blanca E. Callejas, Arthur Wang, Eve Higgins, Aydin Herik, Natalie Andonian, Munazza Yousuf, Pina Colarusso, Maitreyi Raman, Derek M. McKay   +9 more
doaj   +1 more source

Reply

Cellular and Molecular Gastroenterology and Hepatology, 2022
Suchira Gallage, PhD, Adnan Ali, MSc, Jose Efren Barragan Avila, MSc, Mathias Heikenwalder, PhD   +3 more
doaj   +1 more source