Results 61 to 70 of about 1,856,298 (304)

Platelets in chronic liver disease, from bench to bedside

JHEP Reports, 2019
Summary: In the last decade, numerous studies revealed physiologic and pathophysiologic roles of platelets beyond haemostasis, a process to prevent and stop bleeding.
Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder   +3 more
doaj   +1 more source

The role of inflammation in age-related disease. [PDF]

, 2013
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut, Campisi, Judith, Howcroft, T Kevin, Kohanski, Ron, Louis, Germaine Buck, McElhaney, Janet E, Sierra, Felipe, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony   +9 more
core   +2 more sources

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection [PDF]

, 2020
Bovine African Trypanosomosis is an infectious parasitic disease affecting livestock productivity and thereby impairing the economic development of Sub-Saharan Africa. The most important trypanosome species implicated is T.
Brys, Lea, De Baetselier, Patrick, De Trez, Carl, Korf, Hannelie, Magez, Stefan, Stijlemans, Benoit, Van Ginderachter, Jo A   +6 more
core   +1 more source

Chronic Inflammation in Cancer Development [PDF]

Frontiers in Immunology, 2012
Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth, invasion, and metastatic spread; on the other hand inflammation can stimulate immune effector mechanisms that might limit tumor growth.
Gabriele eMulthoff, Gabriele eMulthoff, Gabriele eMulthoff, Michael eMolls, Jürgen eRadons   +4 more
openaire   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

A primary insight into gut microbiome, MicroRNA and stemness, in a PCOS rat model

Journal of Ovarian Research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive and metabolic dysfunctions, including gut microbiome dysbiosis.
Fereshteh Esfandiarinezhad, Xiaoshu Zhan, Seang Lin Tan, Julang Li, Benjamin K. Tsang   +4 more
doaj   +1 more source

Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner [PDF]

, 2017
Background Chronic microglia-mediated inflammation and oxidative stress are well-characterized underlying factors in neurodegenerative disease, whereby reactive inflammatory microglia enhance ROS production and impact neuronal integrity. Recently, it has
Benusa, S. D., DeVries, G. H., Dupree, J. L., George, N. M., Sword, B. A.   +4 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Global DNA methylation signatures associated with chemoresistance and poor prognosis of high grade serous ovarian cancer

Scientific Reports
Ovarian cancer (OVCA) is third most lethal gynecologic cancers and acquired chemoresistance is the key link in the high mortality rate of OVCA patients. Currently, there are no reliable methods to predict chemoresistance in OVCA.
Hafiza Bushra Manzoor, Melisa Acun, Hamed Yasavoli-Sharahi, Chantal Matar, Arvind Mer, Benjamin K. Tsang, Meshach Asare-Werehene   +6 more
doaj   +1 more source