Results 71 to 80 of about 12,467 (152)

Functional immune profiling reveals CD4+ T cell dysregulation in coeliac disease

Immunology &Cell Biology, EarlyView.
The T cell momentum assay quantifies division, survival and activation decay to reveal intrinsic CD4+ programming defects marked by prolonged activation and impaired feedback control in coeliac disease. This scalable platform provides a functional screen for early T cell dysregulation across autoimmune and immune‐mediated diseases.
Anthony J Farchione, HoChan Cheon, David Vremec, Julika Neumann, Gwenny M Verstappen, Melinda Y Hardy, Mai B Margetts, Lauren J Howson, Lee M Henneken, Maureen Forde, Jason A Tye‐Din, Susanne Heinzel, Philip D Hodgkin, Vanessa L Bryant   +13 more
wiley   +1 more source

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Review on Canine Chronic Enteropathy

International Journal of Bio-Resource and Stress Management
A review of literature revealed that diarrhoea and vomition in dogs were frequent reasons for veterinarians to examine dogs, as well as an increase in the occurrence of canine gastrointestinal issues.
Sherry Carelyne Marwein, J. B. Rajesh, Kh Thanila Rose, Payel Kar, S. K. Behera, T. C. Tolenkhomba, K. Sarma   +6 more
doaj   +1 more source

Codocytosis in the Dog: 345 Cases (2020–2022)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Introduction Codocytes, or target cells, are a morphologic variation of erythrocytes characterized by increased membrane surface area relative to volume. In dogs, codocytosis is frequently noted on blood smear evaluation, but its clinical significance remains poorly understood. Objectives To characterize the clinical conditions associated with
Sarena M. Krojanker, Maria Jaramillo, Brad D. Cingolani, Floyd L. Williams Jr., Priscila B. S. Serpa, Andrew D. Woolcock   +5 more
wiley   +1 more source

Faecal Microbiota Transplantation Reduces Lesion Severity and Medication Use in Canine Atopic Dermatitis: A Randomised, Placebo‐Controlled, Double‐Blinded Clinical Trial

Veterinary Dermatology, EarlyView.
Background: Faecal microbiota transplantation (FMT) is an established therapy for gastrointestinal disease, yet its role in canine atopic dermatitis (cAD) remains unclear. Hypothesis/Objectives: We hypothesised that adjunctive FMT improves clinical severity and reduces symptomatic medication use in dogs with cAD.
Vera Felten, Erin Asley West, Franco Martini, Claude Favrot, Stefan Unterer, Jan Suchodolski, Michael Scharl, Harald Renz, Nina Maria Fischer, Ana Rostaher   +9 more
wiley   +1 more source

Endoscopic Visualization of a Jejuno‐Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma

DEN Open, Volume 7, Issue 1, April 2027.
Monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) rarely presents with gastrointestinal fistula formation. A rare case of MEITL is identified in an elderly woman with marked weight loss and hypoalbuminemia, in whom a jejunocolic fistula is directly visualized endoscopically.
Kanami Ota, Yuichi Matsuno, Yoshiaki Taniguchi, Noriyuki Imazu, Shinichiro Kawatoko, Yutaro Ihara, Tomohiro Nagasue, Keisuke Kawasaki, Tomohiko Moriyama, Junji Umeno   +9 more
wiley   +1 more source

Prednisolone pharmacokinetics in dogs with protein‐losing enteropathy

Journal of Veterinary Internal Medicine
Background It is unknown if glucocorticoid malabsorption contributes to the approximate 50% treatment failure rate in dogs with protein‐losing enteropathy (PLE).
Sara A. Jablonski, Jessica L. Strohmeyer, John P. Buchweitz, Andreas F. Lehner, Daniel K. Langlois   +4 more
doaj   +1 more source

Duodenal mucosal RNA-Seq identifies coordinated bile acid–axis transcriptional alterations in food-responsive enteropathy in dogs

Frontiers in Veterinary Science
Food-responsive enteropathy (FRE) is a common form of chronic inflammatory enteropathy in dogs. Its underlying molecular mechanisms remain incompletely characterized.
Borbála Mózes, Gergely Kiss, Ábel Fóthi, Szilamér Ferenczi, Roland Psáder   +4 more
doaj   +1 more source

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5476-5491, July 2026.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source