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Current therapeutic approach of chronic kidney disease-mineral and bone disorder
Therapeutic Apheresis and DialysisAbstractChronic kidney disease (CKD) has emerged as one of the leading noncommunicable diseases affecting >10% of the population worldwide. Bone and mineral disorders are a common complication among patients with CKD resulting in a poor life quality, high fracture risk, increased morbidity and cardiovascular mortality.
Maria Zaimi, Eirini Grapsa
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Chronic Kidney Disease–Mineral-Bone Disorder: A New Paradigm
Advances in Chronic Kidney Disease, 2007Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified on the basis of
Sharon M, Moe +3 more
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UPDATE ON THE TREATMENT OF CHRONIC KIDNEY DISEASE‐MINERAL AND BONE DISORDER
Journal of Renal Care, 2009SUMMARYChronic kidney disease (CKD) is associated with increased morbidity and mortality. Mineral metabolism disturbances appear to contribute to the high mortality rate. A CKD‐mineral bone disorder (CKD‐MBD) has recently been defined as a systemic disorder manifested by one or a combination of abnormalities in bone biopsy, laboratory parameters and/or
Jordi, Bover +7 more
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Chronic Kidney Disease: Mineral and Bone Disorder (CKD-MBD)
2014Chronic kidney disease mineral and bone disorder (CKD-MBD) is defined as a systemic disorder of mineral and bone metabolism due to CKD comprising either one or a combination of the following:
Richard S. Fish, John Cunningham
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The role of osteopontin in chronic kidney disease-mineral bone disorder
Current Opinion in Nephrology & HypertensionPurpose of review Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with several adverse outcomes, including bone fragility and sarcopenia. Identification of new agents mitigating systemic damage related to uremia is critical and needed to unveil pathways implicated in CKD-MBD.
Eduardo J, Duque +2 more
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THE ASSOCIATION OF CHRONIC KIDNEY DISEASE‐MINERAL BONE DISORDER AND CARDIOVASCULAR RISK
Journal of Renal Care, 2010SUMMARYChronic kidney disease‐mineral bone disorder (CKD‐MBD) is a multifaceted definition used to help describe the systemic derangement of mineral bone metabolism in renal disease. This was previously referred to, rather simplistically, as ‘renal osteodystrophy’ or ‘renal bone disease’.
Eddington, Helen, Kalra, Philip A.
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Chronic kidney disease-mineral and bone disorder
JAAPA, 2016ABSTRACT Chronic kidney disease affects 23 million Americans and is associated with many complications, one of the most complex of which is mineral and bone disorder. Pathophysiologic mechanisms begin to occur early in CKD but when the glomerular filtration rate declines to <50% of normal, biochemical and bone matrix abnormalities, which ...
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Effects of aging on chronic kidney disease mineral and bone disorder
Current Opinion in Nephrology & HypertensionPurpose of review Aging and chronic kidney disease mineral and bone disorder (CKD-MBD) interact to worsen bone health, vascular calcification, and frailty in older patients. The altered FGF23–Klotho axis and disrupted mineral homeostasis emphasize the need for early interventions to mitigate fractures and cardiovascular ...
Washington A, Freire-Filho +2 more
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Pathophysiology of chronic kidney disease-mineral and bone disorder
2015Abstract Chronic kidney disease is associated with the inability to control normal mineral homeostasis, resulting in abnormalities in serum levels of calcium, phosphorus, parathyroid hormone, fibroblast growth factor 23 (FGF23) and vitamin D metabolism. These disturbances lead to the development of secondary hyperparathyroidism, skeletal
Ezequiel Bellorin-Font +4 more
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Management of chronic kidney disease-mineral and bone disorder
2015Abstract In all patients with chronic kidney disease (CKD) stages 3–5, regular monitoring of serum markers of CKD-mineral and bone disorder, including calcium (Ca), phosphorus (P), parathyroid hormone (PTH), 25-hydroxyvitamin D, and alkaline phosphatase, is recommended. Target ranges for these markers are endorsed by guidelines.
Thanh-Mai Vo +2 more
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