Results 71 to 80 of about 2,747,113 (394)

Dietary patterns for adults with chronic kidney disease [PDF]

, 2015
This is the protocol for a review and there is no abstract. The objectives are as follows: This review will evaluate the benefits and harms of dietary patterns among adults with CKD (any stage including people with end-stage kidney disease (ESKD) treated
Campbell, Katrina Louise, Craig, Jonathan C, Johnson, David W, Maggo, Jasjot K, Palmer, Suetonia C, Ruospo, Marinella, Strippoli, Giovanni F M, Sutanto, Bernadet, Tong, Allison   +8 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy

Renal Failure
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to the pathogenesis of DN.
Yang Liu, Rong Wu, Zhelun Zhou, Junan Zhou, Jiaai Zhang, Xiaoyi Wang   +5 more
doaj   +1 more source

Research progress on endoplasmic reticulum homeostasis in kidney diseases

Cell Death and Disease, 2023
The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein
Dan Wu, Li-Feng Huang, Xiao-Cui Chen, Xiao-Rong Huang, Hui-Yuan Li, Ning AN, Ji-Xin Tang, Hua-Feng Liu, Chen Yang   +8 more
doaj   +1 more source

Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway

Lupus Science and Medicine, 2022
Objective Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation.Methods
Dan Wu, Chen Yang, Xiao-cui Chen, Hong-luan Wu, Hui-yuan Li, Hong-yong Su, Ze-jian Liu, Xiao-rong Huang, Xing Lu, Li-feng Huang, Shao-ping Zhu, Qing-jun Pan, Ning An, Hua-feng Liu   +13 more
doaj   +1 more source

Machine learning to predict end stage kidney disease in chronic kidney disease

Scientific Reports, 2022
The purpose of this study was to assess the feasibility of machine learning (ML) in predicting the risk of end-stage kidney disease (ESKD) from patients with chronic kidney disease (CKD). Data were obtained from a longitudinal CKD cohort.
Qiong Bai, Chunyan Su, Wen-qi Tang, Yike Li   +3 more
semanticscholar   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Gambaran Kadar Kreatinin Serum Pada Pasien Penyakit Ginjal Kronik Stadium 5 Non Dialisis [PDF]

, 2016
: Chronic kidney disease is a pathophysiology process with various etiology, causing a progressive decline on kidney function, and in general ends with kidney failure (stage 5).
Alfonso, A. A. (Astrid), Memah, M. F. (Maya), Mongan, A. E. (Arthur)   +2 more
core  

Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]

, 2019
The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe, Sievers, Laura Katharina   +1 more
core   +2 more sources

Models of chronic kidney disease [PDF]

Drug Discovery Today: Disease Models, 2010
Chronic kidney diseases result from recurrent or progressive injuries in glomeruli, tubules, interstitium and/or vasculature. In order to study pathogenesis, mechanisms and effects of interventions, many animal models have been developed, including spontaneous, genetic and induced models.
Hai-Chun, Yang, Yiqin, Zuo, Agnes B, Fogo   +2 more
openaire   +2 more sources