Results 101 to 110 of about 4,104,552 (244)

Serum proteome profiling identifies novel and powerful markers of cystic fibrosis liver disease. [PDF]

, 2013
Cystic Fibrosis associated liver disease (CFLD) develops in approximately 30% of CF patients. However, routine sensitive diagnostic tools for CFLD are lacking. Within this study, we aimed to identify new experimental biomarkers for the detection of CFLD.
Richard Schulz, Martin Roderfeld, Roderfeld, Martin, Lisa Hage, Timo Rath (389419), Reinhart Zachoval (76840), Katrin Menendez Menendez (389422), Lutz Naehrlich (389423), Martin Roderfeld (389425), Hage, Lisa, Marion Kügler, Richard Schulz (389424), Marion Kügler (389421), Elke Roeb (389426), Timo Rath, Kügler, Marion, Rath, Timo, Roeb, Elke, Katrin Menendez Menendez, Reinhart Zachoval, Elke Roeb, Menendez Menendez, Katrin, Lutz Naehrlich, Lisa Hage (389420), Zachoval, Reinhart, Naehrlich, Lutz, Schulz, Richard   +26 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Hydrogen sulfide rescues IFNγ/TNFα-induced intestinal epithelial barrier dysfunction by enhancing oxidative phosphorylation

Scientific Reports
The intestinal epithelial barrier is essential for protection against pathogens and toxins while allowing nutrient and water absorption. Barrier dysfunction is increasingly recognized as a key pathophysiological mechanism in diseases affecting the ...
Janaíne Prata de Oliveira, Matthias van Sligtenhorst, Cansu Akkaya, Astrid Verbiest, Victoria Francelino Alves, Marie Wallays, Schalk van der Merwe, Marc Ferrante, Tim Vanuytsel, John L. Wallace, Marcelo N. Muscará, Soraia K. P. Costa, Alexandre Denadai-Souza   +12 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Chronicle

, 2002
These editions of The Chronicle cover a range of topics related to chronic diseases. They include articles about local interventions and programs, research and data, policies, strategies, interstate initiatives, useful resources, upcoming events, and ...
Chronic Diseases Network
core   +1 more source

Machine-learning-guided discovery and prioritization of PD-L1 inhibitors: An open-source KNIME workflow with curated bioactivity data, molecular fingerprints, and applicability-domain assessment

Results in Chemistry
The PD-1/PD-L1 immune checkpoint axis is a validated therapeutic target in oncology, yet systematic computational tools for prioritizing small-molecule PD-L1 inhibitors from large compound libraries remain limited by poor transparency and restricted ...
Monsin Sangsawat, Bunthita Watpuang, Tonkla Nathapinthu, Phuripat Srisiriroj, Nonthaneth Nalinratana, Pasrawin Taechawattananant, Worathat Thitikornpong, Cong Feng, Ming Chen, Pornchai Rojsitthisak   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Love in the Time of Corona [PDF]

Hospital Practices and Research, 2020
Seyed Mohammadreza Hashemian, Amir Vahedian Azimi, Mohamad Amin Pourhoseingholi   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source