Results 21 to 30 of about 2,734,758 (393)

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Role of Intestinal Microbes in Chronic Liver Diseases

International Journal of Molecular Sciences, 2022
With the recent availability and upgrading of many emerging intestinal microbes sequencing technologies, our research on intestinal microbes is changing rapidly.
Mengyi Xu, Kangkang Luo, Junjie Li, Yu Li, Yuxuan Zhang, Zhiyao Yuan, Qiang Xu, Xudong Wu   +7 more
semanticscholar   +1 more source

Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress

Frontiers in Molecular Biosciences, 2020
The study aimed to clarify the role and molecular mechanism of glutamate-cysteine ligase catalytic subunit (GCLC) in modulating Hepatitis C virus (HCV)-related liver fibrosis.
Na Fu, Na Fu, Dongdong Li, Dongdong Li, Wencong Li, Wencong Li, Wen Zhao, Wen Zhao, Siyu Zhang, Siyu Zhang, Lingdi Liu, Lingdi Liu, Suxian Zhao, Suxian Zhao, Jinghua Du, Jinghua Du, Lingbo Kong, Lingbo Kong, Rongqi Wang, Rongqi Wang, Yuguo Zhang, Yuguo Zhang, Yuemin Nan, Yuemin Nan   +23 more
doaj   +1 more source

Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases

Hepatology, 2021
Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non‐alcoholic fatty liver disease and alcohol‐related liver disease, although chronic ...
P. Ginés, L. Castéra, F. Lammert, I. Graupera, Miquel Serra-Burriel, A. Allen, V. Wong, Phillipp Hartmann, M. Thiele, L. Caballería, R. D. de Knegt, I. Grgurević, S. Augustin, E. Tsochatzis, J. Schattenberg, I. Guha, A. Martini, R. Morillas, M. García-Retortillo, H. D. de Koning, N. Fabrellas, J. Pich, A. Ma, Mª Alba Diaz, D. Roulot, P. Newsome, M. Manns, P. Kamath, A. Krag   +28 more
semanticscholar   +1 more source

NLRP3 Inflammasome in Acute and Chronic Liver Diseases. [PDF]

Int J Mol Sci
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that upon external stimuli or contact with specific ligands, recruits other components, forming the NLRP3 inflammasome.
Sayaf K, Battistella S, Russo FP.
europepmc   +2 more sources

Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress

Frontiers in Physiology, 2020
Impaired intestinal barrier function and oxidative stress injury play critical roles in the pathogenesis of alcoholic liver disease (ALD), and recent investigations have revealed a role for dietary copper in the liver and intestinal barrier function ...
Hongwei Lin, Dazhi Chen, Qianjing Du, Tongtong Pan, Hanxiao Tu, Yuedong Xu, Teng Teng, Jingjing Tu, Ji Li, Zhuo Lin, Xiaodong Wang, Lanman Xu, Yong-Ping Chen   +12 more
doaj   +1 more source

Impact of Hepatic Encephalopathy on Clinical Characteristics and Adverse Outcomes in Prospective and Multicenter Cohorts of Patients With Acute-on-Chronic Liver Diseases

Frontiers in Medicine, 2021
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East is unclear.Objective: We aimed to investigate the impact of hepatic ...
Liyuan Long, Hai Li, Hai Li, Hai Li, Guohong Deng, Guohong Deng, Xianbo Wang, Xianbo Wang, Sihong Lu, Beiling Li, Zhongji Meng, Zhongji Meng, Yanhang Gao, Yanhang Gao, Zhiping Qian, Zhiping Qian, Feng Liu, Feng Liu, Feng Liu, Xiaobo Lu, Xiaobo Lu, Haotang Ren, Jia Shang, Hai Li, Shaoyang Wang, Yubao Zheng, Yubao Zheng, Huadong Yan, Huadong Yan, Shan Yin, Shan Yin, Wenting Tan, Qun Zhang, Xin Zheng, Xin Zheng, Jinjun Chen, Jinjun Chen, Sen Luo, Jinming Zhao, Wei Yuan, Tao Li, Rongjiong Zheng, Junping Liu, Xiaoxiao Liu, Wenyi Gu, Wenyi Gu, Sumeng Li, Xue Mei, Ruochan Chen, Yan Huang, Yan Huang   +50 more
doaj   +1 more source

Clinical Utility of Mac-2 Binding Protein Glycosylation Isomer in Chronic Liver Diseases

Annals of Laboratory Medicine, 2021
An accurate evaluation of liver fibrosis is clinically important in chronic liver diseases. Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serum marker for liver fibrosis.
N. Tamaki, M. Kurosaki, R. Loomba, N. Izumi   +3 more
semanticscholar   +1 more source

Specific aspects of social significant liver diseases, risk factors, and food safety: A comprehensive review [PDF]

E3S Web of Conferences, 2023
In the contemporary landscape of scientific inquiry, the study and assessment of risk factors for chronic liver diseases have expanded substantially.
Мamasoliev Ne’matjon, Askarov Ibragim, Khakimov Nasrulla, Salaxidinov Adiljan, Qurbonova Ra’noxon, Kadirov Komiljon   +5 more
doaj   +1 more source

Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases [PDF]

, 2020
MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed in many mammalian cell types.
Han, Sen, Kusumanchi, Praveen, Liangpunsakul, Suthat, Yang, Zhihong, Zhang, Ting   +4 more
core   +1 more source