Results 81 to 90 of about 2,734,758 (393)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Frontiers in Microbiology
BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Chunhai Ke, Lanman Xu, Lanman Xu   +14 more
doaj   +1 more source

Idiopathic noncirrhotic portal hypertension: current perspectives [PDF]

, 2016
The term idiopathic noncirrhotic portal hypertension (INCPH) has been recently proposed to replace terms, such as hepatoportal sclerosis, idiopathic portal hypertension, incomplete septal cirrhosis, and nodular regenerative hyperplasia, used to describe ...
D'AMATI, Giulia, Gioia, Stefania, Nicoletti, Valeria, PENTASSUGLIO, ILARIA, RIGGIO, Oliviero, VALENTE, MICHELE   +5 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges

Frontiers in Molecular Biosciences, 2022
Ferroptosis, an iron-dependent non-apoptotic cell death characterized by lipid peroxidation, is a cell death pathway discovered in recent years. Ferroptosis plays an important role in tumors, ischemia-reperfusion injury, neurological diseases, blood ...
Xiaoxi Zhou, Xiaoxi Zhou, Yadong Fu, Yadong Fu, Yadong Fu, Yadong Fu, Wei Liu, Wei Liu, Yongping Mu, Yongping Mu, Hua Zhang, Hua Zhang, Jiamei Chen, Jiamei Chen, Ping Liu, Ping Liu, Ping Liu   +16 more
doaj   +1 more source

Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]

, 2012
Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Chi, X., Hou, J., Hu, X., Jin, Q., Lv, J., Niu, J., Pan, Y., Sun, H., Tian, Z., Tu, Z., Xiao, W., Xu, D., Yan, H.   +12 more
core   +3 more sources

Etiology and mode of presentation of chronic liver diseases in India: A multi centric study

PLoS ONE, 2017
There is a paucity of health policy relevant data for chronic liver disease from India, impeding formulation of an interventional strategy to address the issue.
P. Mukherjee, S. Vishnubhatla, D. Amarapurkar, K. Das, A. Sood, Y. Chawla, C. Eapen, P. Boddu, V. Thomas, S. Varshney, Diamond Sharma Hidangmayum, P. Bhaumik, B. Thakur, S. Acharya, A. Chowdhury   +14 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Nicotine exacerbates MASH via inducing intestinal dysbiosis and barrier dysfunction

Communications Biology
Nicotine accumulation in the intestine is associated with an exacerbation of metabolic dysfunction-associated steatohepatitis (MASH), but the underlying mechanisms remain enigmatic.
Fangfang Yi, Jinyong Wang, Yi Chen, Yuanhang Xia, Hongfei Zhou, Yilun Huang, Yujuan Shen, Sizhe Fang, Xiaodong Wang, Ya Zhang, Yongping Chen, Dazhi Chen   +11 more
doaj   +1 more source

Impact of gut microbiota on nonalcoholic fatty liver disease: insights from a leave-one-out cross-validation study

Frontiers in Microbiology
IntroductionEnteric dysbacteriosis is strongly associated with nonalcoholic fatty liver disease (NAFLD). However, the underlying causal relationship remains unknown. Thus, the present study aimed to investigate the relationship between gut microbiota and
Tongtong Pan, Lihuang Su, Yiying Zhang, Fangfang Yi, Yongping Chen   +4 more
doaj   +1 more source