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Senotherapy for chronic lung disease. [PDF]

Pharmacol Rev
Chronic respiratory diseases are an enormous burden on healthcare and the third ranked cause of death globally. There is now compelling evidence that acceleration of lung aging and associated cellular senescence is a key driving mechanism of several chronic lung diseases, particularly chronic obstructive pulmonary disease and idiopathic pulmonary ...
Barnes PJ.
europepmc   +4 more sources

BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?

Biology, 2023
Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients.
Greg Hodge, Hubertus Jersmann, Mark Holmes, Patrick Asare, Eugene Roscioli, Paul N. Reynolds, Sandra Hodge   +6 more
doaj   +1 more source

Alvopem® (pemetrexed) safety assessment in patients with non-small cell lung cancer or malignant pleural mesothelioma: a post-marketing surveillance

Journal of Pharmaceutical Policy and Practice, 2023
Background Lung cancer is the leading cause of cancer deaths worldwide in both men and women, and non-small cell lung cancer (NSCLC) accounts for the majority (~ 85%) of lung cancers.
Sharareh Seifi, Babak Salimi, Zahra Esfahani Monfared, Cyrus Sabahi, Hamidreza Kafi, Adnan Khosravi   +5 more
doaj   +1 more source

Hypoxia and chronic lung disease [PDF]

Journal of Molecular Medicine, 2007
The lung is both the conduit for oxygen uptake and is also affected by hypoxia and hypoxia signaling. Decreased ventilatory drive, airway obstructive processes, intra-alveolar exudates, septal thickening by edema, inflammation, fibrosis, or damage to alveolar capillaries will all interpose a significant and potentially life-threatening barrier to ...
Rubin M, Tuder, Jeong H, Yun, Anil, Bhunia, Iwona, Fijalkowska   +3 more
openaire   +2 more sources

Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

Scientific Reports, 2021
E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pregnancy.
Natalia El-Merhie, Arne Krüger, Karin Uliczka, Stephanie Papenmeier, Thomas Roeder, Klaus F. Rabe, Christina Wagner, Hanna Angstmann, Susanne Krauss-Etschmann   +8 more
doaj   +1 more source

Role of airway epithelial cell miRNAs in asthma

Frontiers in Allergy, 2022
The airway epithelial cells and overlying layer of mucus are the first point of contact for particles entering the lung. The severity of environmental contributions to pulmonary disease initiation, progression, and exacerbation is largely determined by ...
Eistine Boateng, Draginja Kovacevic, Vladimira Oldenburg, Madeleine Rådinger, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann   +6 more
doaj   +1 more source

The microbial composition of larval airways from Drosophila melanogaster differ between specimens from laboratory and natural habitats

Environmental Microbiome, 2023
Background The fruit fly Drosophila melanogaster lives in natural habitats and has also long been used as a model organism in biological research. In this study, we used a molecular barcoding approach to analyse the airways microbiome of larvae of D ...
Hanna Angstmann, Stefan Pfeiffer, Susanne Kublik, Birte Ehrhardt, Karin Uliczka, Klaus F. Rabe, Thomas Roeder, Christina Wagner, Michael Schloter, Susanne Krauss-Etschmann   +9 more
doaj   +1 more source

Histopathologic Findings of Olfactory Mucosa in COVID-19 Patients

Otorhinolaryngology and Facial Plastic Surgery, 2023
Background: Olfactory manifestations are common findings during the course of COVID-19, while exact physiopathology is not known Aim: We review histological changes of the nasal olfactory mucosa in COVID-19 non-survivors who died in the ICU ...
Jahangir Ghorbani, Mahin Pourabdollah, Nasim Raad, Mahboobeh Karimi Galougahi, Atefeh Abedini, Behrooz Farzanegan, Seyed Mohammadreza Hashemian, Seyed Alireza Nadji, Amirali Safavi Naini, Ali Safavi Naini   +9 more
doaj   +1 more source

Metabolomics in chronic lung diseases [PDF]

Respirology, 2019
ABSTRACTChronic lung diseases represent a significant global burden. Their increasing incidence and complexity render a comprehensive, multidisciplinary and personalized approach to each patient, critically important. Most recently, unique biochemical pathways and disease markers have been identified through large‐scale metabolomic studies ...
Shabarinath Nambiar, Sze Bong How, Joel Gummer, Robert Trengove, Yuben Moodley   +4 more
openaire   +2 more sources

Immunopathobiology of chronic lung disease [PDF]

Clinical & Translational Immunology, 2020
The lung epithelium is a cellular barrier that protects the lung from environmental exposure to pathogens and chemical insults that could otherwise compromise its physiological role in gas exchange during respiration.
Prêle, C.M., Hoyne, G.F.
openaire   +3 more sources