Results 91 to 100 of about 101,301 (311)

From transformation to chronification of migraine: pathophysiological and clinical aspects

The Journal of Headache and Pain, 2020
Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features.
M. Torres-Ferrús, F. Ursitti, A. Alpuente-Ruiz, F. Brunello, D. Chiappino, T. de Vries, S. Di Marco, S. Ferlisi, L. Guerritore, N. Gonzalez-Garcia, A. Gonzalez-Martinez, D. Khutorov, M. Kritsilis, A. Kyrou, T. Makeeva, A. Minguez-Olaondo, L. Pilati, A. Serrien, O. Tsurkalenko, D. Van den Abbeele, W. S. van Hoogstraten, C. Lampl, On behalf of School of Advanced Studies of European Headache Federation (EHF-SAS)   +22 more
doaj   +1 more source

Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine: Insights from a Real-Life European Multicenter Study [PDF]

, 2021
Raffaele Ornello, Fayyaz Ahmed, Andrea Negro, Anna Maria Miscio, Antonio Santoro, Alicia Alpuente, Antonio Russo, Marcello Silvestro, Sabina Cevoli, Nicoletta Brunelli, Fabrizio Vernieri, Licia Grazzi, Carlo Baraldi, Simona Guérzoni, Anna P. Andreou, Giorgio Lambru, Ilaria Frattale, Katharina Kamm, Ruth Ruscheweyh, Marco Russo, Paola Torelli, E. G. Filatova, Н. В. Латышева, Anna Gryglas‐Dworak, Marcin Straburzyński, Calogera Butera, Bruno Colombo, Massimo Filippi, Patricia Pozo‐Rosich, Paolo Martelletti, Simona Sacco   +30 more
openalex   +1 more source

Choosing the safest acute combination therapy during prophylactic treatment. pharmacokinetic and pharmacodynamic considerations [PDF]

, 2015
Drugs used in the treatment of migraine have been recently reported to be highly associated with the occurrence of clinically significant drug-drug interactions (DDIs)
Lionetto, Luana, MARTELLETTI, Paolo
core   +1 more source

In‐hospital outcomes of lacosamide versus levetiracetam for early adjunctive treatment of status epilepticus: A Nationwide Japanese retrospective cohort study

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Yuichiro Shirota, Masashi Hamada, Kiyohide Fushimi, Tatsushi Toda, Satoshi Kodama   +8 more
wiley   +1 more source

Genes and primary headaches: discovering new potential therapeutic targets [PDF]

, 2013
Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola, Gai, Annalisa, Gentile, Salvatore, Paemeleire, Koen, Pinessi, Lorenzo, Rainero, Innocenzo, Rubino, Elisa, Sarchielli, Paola, Vacca, Alessandro   +8 more
core   +3 more sources

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source

To control or not? A motivational perspective on coping with pain [PDF]

, 2012
Pain relief is often the primordial treatment objective in pain patients. However, an exclusive focus upon pain relief may have costs. Evidence is accumulating that persistent attempts to gain control over pain may, paradoxically, hinder successful ...
Crombez, Geert, Devulder, Jacques, Goubert, Liesbet, Lauwerier, Emelien, Paemeleire, Koen, Van Damme, Stefaan   +5 more
core   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease

Arquivos de Neuro-Psiquiatria
Objective To evaluate cutaneous allodynia among patients with chronic and episodic migraine in a tertiary headache clinic. Methods 80 subjects with episodic migraine and 80 with chronic migraine were assessed in a tertiary hospital.
Mariana Tedeschi Benatto, Lidiane Lima Florencio, Gabriela Ferreira Carvalho, Fabíola Dach, Marcelo Eduardo Bigal, Thaís Cristina Chaves, Débora Bevilaqua-Grossi   +6 more
doaj   +1 more source

Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. [PDF]

, 2017
BACKGROUND: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. METHODS: In this study, the acute effects of recovery between mild head injuries and the frequency of ...
Assari, Soroush, Cheng, Lan, Darvish, Kurosh, Elliott, Melanie B, Tyburski, Ashley L.   +4 more
core   +2 more sources