Results 91 to 100 of about 2,712,287 (341)

Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450

British Journal of Clinical Pharmacology, EarlyView.
Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit, Yeamin Huh, Martin E. Dowty, Anna Plotka, Alexandre Lejeune, Hindu Kalluru, Brian Hee   +6 more
wiley   +1 more source

Life With Migraine: Effects on Relationships, Career, and Finances From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study

Headache, 2019
To assess the effects of migraine on important life domains and compare differences between respondents with episodic and chronic migraine and between sexes.
D. Buse, K. Fanning, M. Reed, Sharron Murray, Paula K. Dumas, A. Adams, R. Lipton   +6 more
semanticscholar   +1 more source

Medications, epilepsy and climate change: Added layers of complexity

British Journal of Clinical Pharmacology, EarlyView.
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi, Seyhmus Gavas, Sanjay M. Sisodiya   +2 more
wiley   +1 more source

Erenumab in chronic migraine with medication overuse

Neurology, 2019
Objective To determine the effect of erenumab, a human anti-calcitonin gene-related peptide receptor monoclonal antibody, in patients with chronic migraine and medication overuse.
S. Tepper, H. Diener, M. Ashina, J. Brandes, D. Friedman, U. Reuter, Sunfa Cheng, Jon Nilsen, Dean K. Leonardi, R. Lenz, D. Mikol   +10 more
semanticscholar   +1 more source

Management of acute and chronic migraine

Current Opinion in Supportive & Palliative Care, 2012
We highlight the recent clinical trials for the management of acute and chronic migraine.In women with menstrual migraine, triptans seem to be well tolerated irrespective of whether or not patients are taking oestrogen-containing contraceptives or have comorbidities that indicate increased cardiovascular risk.
COPPOLA, GIANLUCA, Jean Schoenen
openaire   +4 more sources

The problem of propranolol poisoning

British Journal of Clinical Pharmacology, EarlyView.
Aims Propranolol is licensed in the UK and elsewhere to relieve symptoms of anxiety. In overdose, propranolol poisoning can be serious, difficult to treat and potentially fatal. This paper describes cases of intentional propranolol overdose reported to the UK National Poisons Information Service in order to raise awareness of the risk of harm following
Hayley Williams, Pardeep Jagpal, Euan Sandilands, Emma Morrison, Laurence Gray, Harry Krishna Ruben Thanacoody, Elisha Beg, Sally Bradberry, Robin Ferner   +8 more
wiley   +1 more source

Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease

Arquivos de Neuro-Psiquiatria
Objective To evaluate cutaneous allodynia among patients with chronic and episodic migraine in a tertiary headache clinic. Methods 80 subjects with episodic migraine and 80 with chronic migraine were assessed in a tertiary hospital.
Mariana Tedeschi Benatto, Lidiane Lima Florencio, Gabriela Ferreira Carvalho, Fabíola Dach, Marcelo Eduardo Bigal, Thaís Cristina Chaves, Débora Bevilaqua-Grossi   +6 more
doaj   +1 more source

Increase in trigeminal ganglion neurons that respond to both CGRP and PACAP in mouse models of chronic migraine and post-traumatic headache.

Pain, 2020
A large body of animal and human studies indicate that blocking peripheral calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) signaling pathways may prevent migraine episodes and reduce headache ...
Zhaohua Guo, Katherine Czerpaniak, Jintao Zhang, Y. Cao   +3 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Correlation between migraine subtipes and depression Correlação entre subtipos de migrânea e depressão

Arquivos de Neuro-Psiquiatria, 2008
This study has evaluated depression in patients with episodic migraine (n=98), chronic migraine without medication overuse (n=23), and chronic migraine with medication overuse (n=57).
Renan Barros Domingues, Esther Angélica Coelho Costa, Ariovaldo da Silva Jr, Simone Aires Domingues, Juliana Cardoso Leal, Rodrigo Santiago Gomez, Antônio Lúcio Teixeira Jr   +6 more
doaj   +1 more source