Results 131 to 140 of about 2,555,654 (307)

Investigating the p53 Codon 72 Polymorphism in Patients with Chronic Myeloid Leukemia in Isfahan, Iran

مجله دانشکده پزشکی اصفهان, 2015
Background: The p53 tumor suppressor gene plays important roles in genomic stability. A common polymorphism at codon 72 in the p53 gene has been associated with increased risk for lung, oral, prostate, breast and colorectal cancers.
Mehdi Nikbakht-Dastjerdi, Fatemehsadat Mirabutalebi, Zeinab Ebrahimi   +2 more
doaj  

Management of chronic myeloid leukemia in 2025

Cancer
Abstract Chronic myeloid leukemia (CML) has an annual incidence of approximately two cases per 100,000. The reduction in annual mortality from 10%–20% to 1% with BCR::ABL1 tyrosine kinase inhibitors (TKIs) has resulted in an increased prevalence in the United States of an estimated 150,000 cases in 2025.
Hagop Kantarjian, Massimo Breccia, Fadi G. Haddad, Rüdiger Hehlmann, Ghayas C. Issa, Hemant Malhotra, Franck Emmanuel Nicolini, Koji Sasaki, Leif Stenke, Elias Jabbour   +9 more
openaire   +4 more sources

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Hypoxic conditions confer chemoresistance to crizotinib but not to imatinib in chronic myeloid leukemia cells

Hematology, Transfusion and Cell Therapy
Introduction: Chronic myeloid leukemia is an adult leukemia, constituting 15 % of all leukemia diagnoses. The fundamental driver of disease pathogenesis is the Bcr/Abl fusion protein, characterized by dysregulated tyrosine kinase activity.
Lena Avinery, Danielle Regev, Hazem Khamaisi, Jacob Gopas, Jamal Mahajna   +4 more
doaj   +1 more source

Citizen Science Gamers Enable Automated Flow Cytometry Gating Through Machine Learning

Cytometry Part A, EarlyView.
ABSTRACT Machine learning can greatly accelerate biomedical research but is fundamentally constrained by the scarcity of high‐quality labeled data. We introduce a scalable data‐generation framework based on citizen science and apply it to automated flow cytometry gating, a foundational but subjective step in immunology that limits reproducibility ...
Sebastiano Montante, Daniel Yokosawa, Leon Li, Alexander Butyaev, Mehrnoush Malek, Razzi Movassaghi, Quentin Michalchuk, Chieh‐Ting Jimmy Hsu, David Shmil, Albina Rahim, Andrea Cossarizza, Julia Boira Esteban, Kornél Erhart, Bergur Finnbogason, George Kelion, Hjalti Leifsson, Josh Rivers, David Ecker, Attila Szantner, Jérôme Waldispühl, Ryan R. Brinkman   +20 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

A randomized study of interferon-α versus interferon-α and low-dose arabinosyl cytosine in chronic myeloid leukemia

, 2002
Interferon-α (IFN-α) has significantly prolonged survival in chronic myeloid leukemia (CML), but some patients do not respond and many responses are not durable.
Domenico Russo, Antonio de Vivo, Francesca Bonifazi, Mauro Fiacchini, Giuseppe Saglio, LIBERATI, Anna Marina, Michele Baccarani, Marilina Amabile, Gianantonio Rosti, Enrico Montefusco, et a., Nicoletta Testoni, Giovanni Martinelli, Sante Tura for the Italian Cooperative Study Group on Chronic Myeloid Leukemia   +13 more
core   +1 more source

Treatment-Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure. [PDF]

Cancer Sci
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Ureshino H, Kimura S.
europepmc   +2 more sources

Circulating monocyte partitioning and its alteration in hematological chronic neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Circulating monocyte partitioning refers to the relative quantification of the three main monocyte subsets in the peripheral blood, namely classical (cMo), intermediate (iMo), and non‐classical (ncMo) monocytes, as assessed by flow cytometry, a new nomenclature described 15 years ago.
Sihem Tarfi, Dorothée Selimoglu‐Buet, Ivan Sloma, Orianne Wagner‐Ballon, on behalf of the French group CytHem‐LMMC   +4 more
wiley   +1 more source

Coexistence of immunophenotypically normal and aberrant mast cells in patients with clonal mast cell diseases associates with more indolent subtypes and less severe disease characteristics

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Aberrant antigen expression on mast cells (MCs) is one of the most accurate diagnostic markers for clonal MC diseases (CMCD). Although the coexistence of normal and pathologic MCs is frequently seen, the disease characteristics associated with it have been minimally investigated.
Abdulrazzaq Alheraky, Kees Meijer, Marije Nijk, Saskia K. Klein, Hanneke N. G. Oude Elberink, Ido P. Kema, André B. Mulder   +6 more
wiley   +1 more source