Results 91 to 100 of about 385,949 (304)

Tadalafil in patients with chronic obstructive pulmonary disease:a randomised, double-blind, parallel-group, placebo-controlled trial [PDF]

, 2014
Background: Phosphodiesterase-5 (PDE5) inhibitors improve exercise capacity and quality of life in patients with idiopathic pulmonary arterial hypertension.
Lipworth, Brian J., Hopkinson, Pippa J, Struthers, Allan D., Goudie, Andrew R, Hopkinson, Pippa J., Lipworth, Brian J, Goudie, Andrew R., Wei, Li, Struthers, Allan D   +8 more
core   +1 more source

Design Strategies and Emerging Applications of High‐Performance Flexible Piezoresistive Pressure Sensors

Advanced Functional Materials, EarlyView.
Flexible piezoresistive pressure sensors underpin wearable and soft electronics. This review links sensing physics, including contact resistance modulation, quantum tunneling and percolation, to unified materials/structure design. We highlight composite and graded architectures, interfacial/porous engineering, and microstructured 3D conductive networks
Feng Luo, Artur Ciesielski, Paolo Samorì   +2 more
wiley   +1 more source

Prevalence and clinical characteristics of fibromyalgia syndrome in individuals with chronic obstructive pulmonary disease: A cross-sectional study

Journal of International Medical Research
Objective This study investigated the prevalence of fibromyalgia syndrome in individuals with chronic obstructive pulmonary disease and examined its association with the demographic and clinical variables of these individuals.
Suat Konuk, Alp Özel, Emine Özsarı, Aşkın Nasırcılar   +3 more
doaj   +1 more source

Long-term exposure to outdoor air pollution and the incidence of chronic obstructive pulmonary disease in a national English cohort. [PDF]

, 2014
OBJECTIVES: The role of outdoor air pollution in the incidence of chronic obstructive pulmonary disease (COPD) remains unclear. We investigated this question using a large, nationally representative cohort based on primary care records linked to hospital
Van Staa, Tjeerd; id_orcid, van Staa, TP, Anderson, HR, Carey, I M, Kent, AJ, Kent, A J, van Staa, T P, Atkinson, R W, Sub Pharmacoepidemiology, Atkinson, RW, Anderson, H R, Pharmacoepidemiology and Clinical Pharmacology, Carey, IM, Cook, DG, Cook, D G   +14 more
core   +1 more source

Biologics and chronic obstructive pulmonary disease [PDF]

Journal of Allergy and Clinical Immunology, 2018
The presence of airway inflammation in patients with chronic obstructive pulmonary disease (COPD) provides a rationale for biological agents targeting specific inflammatory pathways. This approach has been strikingly effective in patients with other chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, and asthma.
openaire   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells

Antioxidants
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases.
Corinne Hamblet, Karin Björhall, Susann Busch, Ulf Gehrmann, Lisa Öberg, Rebekka Kubisch-Dohmen, Sonja Haas, Manish K. Aneja, Johannes Geiger, Carsten Rudolph, Ellinor Hornberg   +10 more
doaj   +1 more source

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Portable Breathing Monitoring With Phase‐Resolved Airflow Dynamics Enabled by a Dual‐Response Flexible PZT Sensor

Advanced Healthcare Materials, EarlyView.
A portable respiratory monitoring device based on a flexible PZT sensor captures pressure‐ and temperature‐related airflow responses in a single waveform. Polarity‐opposed piezoelectric and pyroelectric components generate a narrow transient spike and a broad quasi‐steady peak during both inhalation and exhalation. This dual‐component structure enables
Minyu Li, Jun Aoyama, Yuchao Wu, Tomomi Uchiyama, Kosho Yoshikawa, Toshiki Mano, Yuxi Song, Hedong Zhang   +7 more
wiley   +1 more source