Results 111 to 120 of about 6,002,276 (336)

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony

Cardiovascular Diabetology, 2012
Chronic obstructive pulmonary disease, metabolic syndrome and diabetes mellitus are common and underdiagnosed medical conditions. It was predicted that chronic obstructive pulmonary disease will be the third leading cause of death worldwide by 2020.
Mirrakhimov Aibek E
doaj   +1 more source

Chronic obstructive pulmonary disease – a treatable disease

Swiss Medical Weekly, 2013
Chronic obstructive pulmonary disease (COPD) is a global health challenge and a leading cause of death worldwide. Several risk factors have been identified, with cigarette smoking being the most important. Diagnostic assessment is based on symptoms, risk of exacerbations and results of lung function testing.
Osthoff M, Jenkins C, Leuppi J
openaire   +4 more sources

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations

Nature Genetics, 2019
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from
P. Sakornsakolpat, Dmitry Prokopenko, M. Lamontagne, N. Reeve, A. Guyatt, V. Jackson, N. Shrine, D. Qiao, Traci M. Bartz, D. Kim, Mi Kyeong Lee, J. Latourelle, Xingnan Li, J. Morrow, M. Obeidat, A. Wyss, P. Bakke, R. Barr, T. Beaty, S. Belinsky, G. Brusselle, J. Crapo, K. Jong, D. Demeo, T. Fingerlin, S. Gharib, A. Gulsvik, I. Hall, J. Hokanson, W. Kim, D. Lomas, S. London, D. Meyers, G. O'Connor, S. Rennard, D. Schwartz, P. Śliwiński, D. Sparrow, D. Strachan, R. Tal-Singer, Y. Tesfaigzi, J. Vestbo, J. Vonk, J. Yim, Xiaobo Zhou, Y. Bossé, A. Manichaikul, L. Lahousse, E. Silverman, H. Boezen, L. Wain, M. Tobin, B. Hobbs, M. Cho, C. Batini, Jinghua Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Ewert, C. Gieger, G. Homuth, P. Joshi, C. Langenberg, Lars Lind, J. Luan, A. Mahajan, A. Murray, D. Porteous, R. Rawal, Blair H. Smith, P. Timmers, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, C. Hayward, Andrew P Morris, A. Agustí, W. Anderson, N. Bakerly, R. Bals, K. Barnes, E. Bleecker, R. Bowler, C. Brightling, Marleen de Bruijne, P. Castaldi, B. Celli, H. Coxson, R. Crystal, P. D. Jong, A. Dirksen, J. Dy, M. Foreman, J. Garcia-Aymerich, P. Gevenois, Soumitra Ghosh, H. Gietema, N. Hansel, C. Hersh, E. Hoffman, N. Kalsheker, H. Kauczor, Tarja Laitinen, D. Lambrechts, Sang-Do Lee, A. Litonjua, D. Loth, S. Lutz, D. Lynch, W. Macnee, Merry-Lynn N. McDonald, J. Newell, B. Nordestgaard, Y. Oh, P. Paré, M. Pistolesi, D. Postma, M. Puhan, E. Regan, S. Rich, J. Seo, Andrea B. Short, B. Stoel, N. Sverzellati, G. Riet, E. V. Beek, B. Ginneken, C. Vogelmeier, A. Wanner, G. Washko, E. Wauters, E. Wouters, R. Young, L. Zeigler-Heitbrock   +156 more
semanticscholar   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Transcriptional Dynamics of NRF2 Overexpression and KEAP1-NRF2 Inhibitors in Human Cell Line and Primary Lung Cells

Antioxidants
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, and infection) to drive pathology in a number of lung diseases.
Corinne Hamblet, Karin Björhall, Susann Busch, Ulf Gehrmann, Lisa Öberg, Rebekka Kubisch-Dohmen, Sonja Haas, Manish K. Aneja, Johannes Geiger, Carsten Rudolph, Ellinor Hornberg   +10 more
doaj   +1 more source

Serum bilirubin level is associated with exercise capacity and quality of life in chronic obstructive pulmonary disease

Respiratory Research, 2019
Background Bilirubin has antioxidant properties against chronic respiratory diseases. However, previous studies are limited by acquisition of serum bilirubin level at one time point and its analysis with clinical parameters.
Ah Young Leem, Young Sam Kim, Ji-Hyun Lee, Tae-Hyung Kim, Ha Yan Kim, Yeon Mok Oh, Sang Do Lee, Ji Ye Jung   +7 more
doaj   +1 more source

Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease. [PDF]

, 2011
BACKGROUND: The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
Fabbri, Leonardo M., Caracta, C, Stephen I Rennard, James F Donohue, Caracta, Cynthia, Gil, Esther Garcia, Jones, PW, Donohue, JF, Magnussen, Helgo, Bateman, ED, Nicholas J Gross, Bateman, Eric D, Channez, Pascal, Fabbri, L, Agusti, Alvar, Lamarca R, Gross Nicholas J, Magnussen Helgo, Gil, Esther G, Cynthia Caracta, Caracta Cynthia, Chanez P, Jones, Paul, Agusti Alvar, Paul W Jones, Lamarca, R, Bateman, Eric D., Jones, Paul W., Gross, Nicholas J, Esther Garcia Gil, Agusti A, Gil, Esther, Rosa Lamarca, Alvar Agusti, Jones, Paul W, Chanez, P, Fabbri Leonardo, Magnussen H, Helgo Magnussen, Donohue JF, Gil, EG, Magnussen, H, Donohue James F, Gross, Nicholas J., Garcia Gil, Esther, Jones PW, Rennard, SI, Lamarca, Rosa, Gross NJ, Agusti, A, Caracta C, Eric D Bateman, Jones Paul W, Gil Esther, Chanez, Pascal, Donohue, James F, Donohue, James F., Bateman Eric D, Rennard, Stephen I., Bateman, Eric, Rennard Stephen I, Gross, Nicholas, Gross, NJ, Pascal Chanez, Rennard, Stephen, Bateman ED, Agustí García-Navarro, Àlvar, Lamarca Rosa, Chanez Pascal, Rennard, Stephen I, Rennard SI, Gil EG, Fabbri, Leonardo, Leonardo Fabbri, Donohue, James   +74 more
core   +2 more sources

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease [PDF]

, 2012
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropium are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease.
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source