Results 71 to 80 of about 541,960 (339)

Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease.

New England Journal of Medicine, 2015
BACKGROUND Chronic obstructive pulmonary disease (COPD) is thought to result from an accelerated decline in forced expiratory volume in 1 second (FEV1) over time.
P. Lange, B. Celli, A. Agustí, Gorm Boje Jensen, M. Divo, R. Faner, S. Guerra, J. Marott, F. Martinez, P. Martínez-Camblor, P. Meek, C. Owen, H. Petersen, V. Pinto-Plata, P. Schnohr, A. Sood, J. Soriano, Y. Tesfaigzi, J. Vestbo   +18 more
semanticscholar   +1 more source

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

CAT-test significance in life quality assessment in patients with chronic obstructive pulmonary disease [PDF]

Саратовский научно-медицинский журнал, 2010
Comprehensive analysis of the impact of complex vaccination against pneumococcus, Haemophilus influenzae type b and influenza on performance CAT-test 6 months after vaccination in patients with chronic obstructive pulmonary disease compared with ...
Protasov A.D., Zhestkov A.M, Shanina I.Yu.   +2 more
doaj  

Pathogenesis of Chronic Obstructive Pulmonary Disease [PDF]

Clinics in Chest Medicine, 2005
The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a number of injurious processes, including an abnormal inflammatory response in the lungs to inhaled particles and gases. Other processes, such as failure to resolve inflammation, abnormal cell repair, apoptosis, abnormal cellular maintenance programs, extracellular matrix ...
openaire   +7 more sources

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations

Nature Genetics, 2019
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from
P. Sakornsakolpat, Dmitry Prokopenko, M. Lamontagne, N. Reeve, A. Guyatt, V. Jackson, N. Shrine, D. Qiao, Traci M. Bartz, D. Kim, Mi Kyeong Lee, J. Latourelle, Xingnan Li, J. Morrow, M. Obeidat, A. Wyss, P. Bakke, R. Barr, T. Beaty, S. Belinsky, G. Brusselle, J. Crapo, K. Jong, D. Demeo, T. Fingerlin, S. Gharib, A. Gulsvik, I. Hall, J. Hokanson, W. Kim, D. Lomas, S. London, D. Meyers, G. O'Connor, S. Rennard, D. Schwartz, P. Śliwiński, D. Sparrow, D. Strachan, R. Tal-Singer, Y. Tesfaigzi, J. Vestbo, J. Vonk, J. Yim, Xiaobo Zhou, Y. Bossé, A. Manichaikul, L. Lahousse, E. Silverman, H. Boezen, L. Wain, M. Tobin, B. Hobbs, M. Cho, C. Batini, Jinghua Zhao, M. Wielscher, S. Weiss, K. Kentistou, J. Cook, J. Hui, S. Karrasch, M. Imboden, S. Harris, J. Marten, Stefan Enroth, S. Kerr, I. Surakka, V. Vitart, T. Lehtimäki, R. Ewert, C. Gieger, G. Homuth, Peter K. Joshi, C. Langenberg, L. Lind, J. Luan, A. Mahajan, Alison D. Murray, D. Porteous, R. Rawal, Blair H. Smith, P. Timmers, O. Raitakari, M. Kähönen, O. Polašek, U. Gyllensten, I. Rudan, I. Deary, N. Probst-Hensch, H. Schulz, A. James, James F. Wilson, B. Stubbe, E. Zeggini, M. Jarvelin, N. Wareham, C. Hayward, Andrew P Morris, A. Agustí, W. Anderson, N. Bakerly, R. Bals, Kathleen C. Barnes, E. Bleecker, Russell P Bowler, C. Brightling, Marleen de Bruijne, P. Castaldi, B. Celli, H. Coxson, R. Crystal, P. D. Jong, A. Dirksen, J. Dy, M. Foreman, J. Garcia-Aymerich, P. Gevenois, Soumitra Ghosh, H. Gietema, N. Hansel, C. Hersh, E. Hoffman, N. Kalsheker, H. Kauczor, Tarja Laitinen, D. Lambrechts, Sang-Do Lee, A. Litonjua, D. Loth, S. Lutz, D. Lynch, W. Macnee, Merry-Lynn N. McDonald, J. Newell, B. Nordestgaard, Y. Oh, P. Paré, M. Pistolesi, D. Postma, M. Puhan, E. Regan, S. Rich, J. Seo, Andrea B. Short, B. Stoel, N. Sverzellati, G. Riet, E. V. Beek, B. Ginneken, C. Vogelmeier, A. Wanner, G. Washko, E. Wauters, E. Wouters, R. P. Young, L. Zeigler-Heitbrock   +156 more
semanticscholar   +1 more source

Seeing inside the Body Using Wearable Sensing and Imaging Technologies

Advanced Healthcare Materials, EarlyView.
This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim, Seunghun Han, Sehwan Park, Jahyun Koo   +3 more
wiley   +1 more source

COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary diseases, 2019
Background Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria.
Katherine E. Lowe, E. Regan, A. Anzueto, E. Austin, J. Austin, T. Beaty, P. Benos, Christopher J Benway, S. Bhatt, E. Bleecker, Sandeep Bodduluri, J. Bon, A. Boriek, A. Boueiz, R. Bowler, M. Budoff, R. Casaburi, P. Castaldi, J. Charbonnier, M. Cho, A. Comellas, D. Conrad, Corinne Costa Davis, G. Criner, D. Curran-Everett, J. Curtis, D. Demeo, A. Díaz, M. Dransfield, Jennifer G. Dy, A. Fawzy, M. Fleming, E. Flenaugh, M. Foreman, Spyridon Fortis, H. Gebrekristos, S. Grant, P. Grenier, T. Gu, Abhya Gupta, M. Han, N. Hanania, N. Hansel, L. Hayden, C. Hersh, B. Hobbs, E. Hoffman, J. Hogg, J. Hokanson, K. Hoth, A. Hsiao, S. Humphries, K. Jacobs, F. Jacobson, E. Kazerooni, V. Kim, W. Kim, G. Kinney, H. Koegler, S. Lutz, D. Lynch, Neil R MacIntye, B. Make, N. Marchetti, F. Martinez, D. Maselli, A. Mathews, M. McCormack, Merry-Lynn N. McDonald, C. Mcevoy, M. Moll, Sarah S Molye, S. Murray, H. Nath, J. Newell, M. Occhipinti, M. Paoletti, T. Parekh, M. Pistolesi, K. Pratte, N. Putcha, M. Ragland, J. Reinhardt, S. Rennard, R. Rosiello, J. Ross, H. Rossiter, I. Ruczinski, Raúl San José Estépar, F. Sciurba, J. Sieren, Harjinder Singh, Xavier Soler, R. Steiner, M. Strand, W. Stringer, R. Tal-Singer, B. Thomashow, Gonzalo Vegas Sánchez-Ferrero, J. Walsh, E. Wan, G. Washko, J. Michael Wells, C. Wendt, G. Westney, A. Wilson, R. Wise, A. Yen, K. Young, J. Yun, E. Silverman, J. Crapo   +111 more
semanticscholar   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Unraveling the Complexities of Coagulation Dysfunction in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Investigating the Interplay between Infection, Hypercapnia and Hemostatic Abnormalities

Life and Science
Objective: To understand how the acute exacerbations of chronic obstructive pulmonary disease (COPD) can lead to coagulation dysfunctions causing hemostatic abnormalities (prolonged prothrombin time, slightly longer activated partial thromboplastin time,
Bilal Ahmed, Muhammad Imran, Nimra Naeem, Usman Haider, Muhammad Atif Rauf, Qaiser Iqbal   +5 more
doaj   +1 more source