Results 51 to 60 of about 3,759 (138)

Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis

Biology, 2021
A deficient epidermal barrier is a key feature of atopic dermatitis (AD) and comprises altered lipid and protein content and composition of the stratum corneum resulting in disturbed water balance.
Regina Fölster-Holst, Rahel Reimer, Claudia Neumann, Erhardt Proksch, Elke Rodriguez, Stephan Weidinger, Mohamad Goldust, Eckhard Hanisch, Stephan Dähnhardt-Pfeiffer, Sandra Freitag-Wolf   +9 more
doaj   +1 more source

Phenotypes and clinical outcomes in children with moderate‐to‐severe atopic dermatitis across diverse ancestries: a Spanish multicenter observational study and cluster analysis (AD‐SKINS Project)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Atopic dermatitis (AD) has a highly variable clinical phenotype and ancestry can contribute to this heterogeneity. This study aims to identify clinical phenotypes of AD in children from diverse ancestry groups, evaluate clinical outcomes and response to treatment, and define phenotypic clusters with potential relevance.
Eugeni Prat‐Colilles, Adrià Plana‐Pla, Asunción Vicente, Eulàlia Baselga, Helena Iznardo, Esther Roé, Miquel Casals‐Andreu, Maria Sin‐Soler, Josep A. Pujol‐Montcusí, Maria del Mar Cordellat‐Martínez, Xavier Soria‐Gili, Maria del Mar Tapias‐Terré, Marta Bertolin‐Colilla, Nidia Planella‐Fontanillas, Laura Marques‐Martín, Mónica Munera‐Campos, Maria Fabregat‐Pratdepadua, Carolina S. Prat‐Torres, Marta Ivars, Luisa F. Montenegro‐Morillo, Isabel Bielsa‐Marsol, Jose‐Manuel Carrascosa‐Carrillo   +21 more
wiley   +1 more source

Chronic Prurigo of Nodular Type: A Review

Acta Dermato-Venereologica, 2017
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules.
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer   +5 more
doaj   +1 more source

Quick assessment of quality‐of‐life in itch: An exploratory validation of the 5‐item pruritus life quality

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) significantly impairs quality of life (QoL), but existing patient‐reported QoL tools are either not specific for CP or are very extensive. Patients and methods The 5‐item pruritus life quality (5PLQ, range: 5–25, 7‐day recall) was developed to assess key itch‐related QoL domains (sensory symptoms,
Claudia Zeidler, Simone Garcovich, Svetlana Bobko, Franz J. Legat, Andrey Lvov, Emilie Brenaut, Adam Reich, Esther Serra‐Baldrich, Laurent Misery, Jacek C. Szepietowski, Martin Dugas, Felix Aulenbacher, Pascale Salameh, Sonja Ständer, Manuel P. Pereira   +14 more
wiley   +1 more source

Prurigo Nodularis in a Patient With Primary B‐Cell Immunodeficiency Successfully Treated With Low‐Dose Methotrexate: A Case Report

Clinical Case Reports
Prurigo nodularis is a chronic pruritic condition that leads to a vicious itch‐scratch cycle, which can significantly impair quality of life. Low‐dose methotrexate is an effective option for patients with chronic nodular prurigo not responding to topical
Hamad El Hajj, Dima Jeha, Jennifer Abi Younis, Peter Noun, Maya Habre   +4 more
doaj   +1 more source

Digital Dermatology

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Digital transformation is fundamentally reshaping dermatology, creating new opportunities in diagnostics, therapy, and healthcare organization. Large datasets combined with Artificial Intelligence (AI) enable more precise classification and prognosis, particularly through the analysis of clinical and dermoscopic imaging.
Lea Henkel, Avend Bamarni, Stephan Alexander Braun, Valentina Busik, Holger Andreas Haenssle, Stephan Rietz, Paul Schmidle, Sandra Schuh, Anna‐Theresa Seitz, Sebastian Sitaru, Stephan Traidl, Max Tischler, Felix von Krogh, Julia Welzel, Julia Winkler, Anastasia Sophie Vollmer, Katharina Susanne Kommoss, Alexander Zink   +17 more
wiley   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

Minimal Disease Activity as A New Therapeutic Target in Atopic Dermatitis: A 5‐Year Real‐Life Experience With Dupilumab

International Journal of Dermatology, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant physical and psychosocial burden. Dupilumab, a monoclonal antibody targeting IL‐4Rα, has proven to be effective for moderate‐to‐severe AD, but long‐term real‐world data remain limited.
Francesco Leo, Luca Mastorino, Luca Cangialosi, Davide Favre, Chiara Anna Fiasconaro, Yingying Liao, Federico Goso, Niccolò Siliquini, Giovanni Cavaliere, Pietro Quaglino, Simone Ribero, Michela Ortoncelli   +11 more
wiley   +1 more source

Transcriptomic analysis of skin biopsies in Prurigo nodularis patients: with and without atopic dermatitis. [PDF]

Front Immunol
BackgroundNodular dermatitis (PN) is a severely itchy chronic skin disease with symmetrically distributed nodules, often linked to an atopic background in some patients.
Lee SY, Um JY, Kim HB, Yang HW, Kwak IS, Chung BY, Park CW, Kim HO.   +7 more
europepmc   +2 more sources

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source