Results 51 to 60 of about 1,647,688 (179)

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Acta Dermato-Venereologica, 2017
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients ...
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz   +7 more
doaj   +1 more source

European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo

, 2017
Background: The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing.
M. Storck, M. Dugas, Steinke, S., Streit, M., U. Gieler, Pereira, M.P., Wallengren, J., M. Streit, Wollenberg, A., S. Ständer, K. Weller, I. Soto-Rey, Weller, K., F.J. Legat, M. Augustin, J. Wallengren, E. Şavk, E. Weisshaar, Gieler, U., Ständer, H.F., S. Garcovich, Legat, F.J., E. Serra-Baldrich, C. Forner, Garcovich, S., Bruland, Philipp, Gonçalo, M., Halvorsen, J. A., Leslie, T.A., Reich, A., null null, C. Zeidler, H.F. Ständer, Forner, C., J.C. Szepietowski, Augustin, M., S. Bobko, P. Bruland, S. Steinke, Zeidler, C., A. Reich, A. Wollenberg, Ständer, S., Elberling, J., C. Riepe, G. Schneider, Serra‐Baldrich, E., F. Dalgard, Schneider, G., J. A. Halvorsen, Bobko, S., Dugas, M., M. Metz, Soto‐Rey, I., Şavk, E., M. Gonçalo, M.P. Pereira, Szepietowski, J.C., Storck, M., J. Elberling, Dalgard, F., T.A. Leslie, Riepe, C., Weisshaar, E., Metz, M.   +64 more
core   +2 more sources

An Atypical Skin Presentation of Adult‐Onset Still's Disease With Histological Description: A Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Adult‐onset Still's disease (AOSD) is an auto inflammatory disorder with a variable clinical presentation, and without a pathognomonic diagnostic test, characterized by high spiking fever, arthralgia/arthritis, a suggestive skin rash, elevated white blood cell count 10 G/L (> 80% neutrophils), elevated ferritin, with glycosylated ferritin < 20%
M. Nordmann, T. Mazza, S. Menzinger, G. Kaya, S. Bogiatzi, S. Vandenberghe‐Dürr, M. Blanchard, J. Stirnemann   +7 more
wiley   +1 more source

Elevated lymphoma risk in patients with chronic pruritus and chronic prurigo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) and chronic prurigo (CPG, including prurigo nodularis) are prevalent, debilitating diseases with diverse comorbidities, including malignancies. This retrospective cohort study evaluated the prevalence and risk of lymphoma in CP and CPG patients, including key risk factors, and sex‐ and ancestry ...
Svenja Royeck, Henning Olbrich, Steffen Koschmieder, Claudia Zeidler, Felix Witte, Konstantin Agelopoulos, Henning Wiegmann, Michael Storck, Johannes Benedict Oehm, Ralf J. Ludwig, Sonja Ständer   +10 more
wiley   +1 more source

Impact of chronic prurigo nodularis on daily life and stigmatization

Journal of the European Academy of Dermatology and Venereology, 2023
International ...
Misery, Laurent, Patras de Campaigno, Christine, Taieb, Charles, Thénié, Claire, Meyer, Cedric, Marquié, Adrien, Paul, Carle, Tauber, Marie   +7 more
openaire   +4 more sources

Phenotypes and clinical outcomes in children with moderate‐to‐severe atopic dermatitis across diverse ancestries: a Spanish multicenter observational study and cluster analysis (AD‐SKINS Project)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Atopic dermatitis (AD) has a highly variable clinical phenotype and ancestry can contribute to this heterogeneity. This study aims to identify clinical phenotypes of AD in children from diverse ancestry groups, evaluate clinical outcomes and response to treatment, and define phenotypic clusters with potential relevance.
Eugeni Prat‐Colilles, Adrià Plana‐Pla, Asunción Vicente, Eulàlia Baselga, Helena Iznardo, Esther Roé, Miquel Casals‐Andreu, Maria Sin‐Soler, Josep A. Pujol‐Montcusí, Maria del Mar Cordellat‐Martínez, Xavier Soria‐Gili, Maria del Mar Tapias‐Terré, Marta Bertolin‐Colilla, Nidia Planella‐Fontanillas, Laura Marques‐Martín, Mónica Munera‐Campos, Maria Fabregat‐Pratdepadua, Carolina S. Prat‐Torres, Marta Ivars, Luisa F. Montenegro‐Morillo, Isabel Bielsa‐Marsol, Jose‐Manuel Carrascosa‐Carrillo   +21 more
wiley   +1 more source

Quick assessment of quality‐of‐life in itch: An exploratory validation of the 5‐item pruritus life quality

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) significantly impairs quality of life (QoL), but existing patient‐reported QoL tools are either not specific for CP or are very extensive. Patients and methods The 5‐item pruritus life quality (5PLQ, range: 5–25, 7‐day recall) was developed to assess key itch‐related QoL domains (sensory symptoms,
Claudia Zeidler, Simone Garcovich, Svetlana Bobko, Franz J. Legat, Andrey Lvov, Emilie Brenaut, Adam Reich, Esther Serra‐Baldrich, Laurent Misery, Jacek C. Szepietowski, Martin Dugas, Felix Aulenbacher, Pascale Salameh, Sonja Ständer, Manuel P. Pereira   +14 more
wiley   +1 more source

Narrowband-ultraviolet B vs Broadband-ultraviolet B in Treatment of Chronic Pruritus: A Randomized, Single-blinded, Non-inferiority Study

Acta Dermato-Venereologica, 2023
Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g.
Romana Kupsa, Alexandra Gruber-Wackernagel, Angelika Hofer , Franz Quehenberger , Peter Wolf, Franz J. Legat   +5 more
doaj   +1 more source

Chronic hemicorporal prurigo related to a posttraumatic Brown-Séquard syndrome

, 2008
Focal pruritus may have a neurological cause. According to the underlying mechanism, two categories of central itch have been distinguished, neuropathic and neurogenic pruritus. We here describe a patient with Brown-Séquard syndrome related to unilateral
Thielen, A M., Borradori, Luca, Vokatch, N.   +2 more
core   +1 more source