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Long-term CMV monitoring and chronic rejection in renal transplant recipients [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionCytomegalovirus (CMV) is well established to be an independent risk factor for graft loss after kidney transplantation (KTx). Monitoring for CMV in the chronic phase is not defined in the current guideline.
Shoko Ishikawa, Masayuki Tasaki, Kazuhide Saito, Yuki Nakagawa, Yuki Nakagawa, Masahiro Ikeda, Kota Takahashi, Yoshihiko Tomita   +7 more
doaj   +2 more sources

Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation [PDF]

SAGE Open Medicine, 2020
Objectives: This report summarizes a collaborative effort between the American Society of Reconstructive Transplantation and the International Society of Vascularized Composite Allotransplantation to establish what is known about chronic rejection in ...
Christina L Kaufman, Jean Kanitakis, Annemarie Weissenbacher, Gerald Brandacher, Mandeep R Mehra, Hatem Amer, Bettina G Zelger, Bernhard Zelger, Bohdan Pomahac, Sue McDiarmid, Linda Cendales, Emmanuel Morelon   +11 more
doaj   +2 more sources

A chronic rejection model and potential biomarkers for vascularized composite allotransplantation. [PDF]

PLoS ONE, 2020
BackgroundChronic rejection remains the Achilles heel in vascularized composite allotransplantation. Animal models to specifically study chronic rejection in vascularized composite allotransplantation do not exist so far.
Flemming Puscz, Mehran Dadras, Alexander Dermietzel, Frank Jacobsen, Marcus Lehnhardt, Björn Behr, Tobias Hirsch, Maximilian Kueckelhaus   +7 more
doaj   +2 more sources

Chronic rejection models for vascularized composite tissue allotransplantation [PDF]

Scientific Reports
Vascularized composite tissue allotransplantation (VCA) has transformed patients’ lives by enabling limb, face, abdominal wall, and penile transplants.
Daniel T. Fisher, Emily Mackey, Eugene Kononov, Paul N. Bogner, Umesh Sharma, Han Yu, Curtis L. Cetrulo, Mukund Seshadri, Pawel Kalinski, Joseph J. Skitzki, Elizabeth A. Repasky, Minhyung Kim   +11 more
doaj   +2 more sources

Macrophages in Chronic Rejection: The Shapeshifters Behind Transplant Survival [PDF]

Biology
Background: Organ transplant offers patients a second chance at life, yet chronic rejection remains a formidable barrier to long-term success. Unlike the instantaneous storm of acute rejection, chronic rejection is a slow, unremitting process that ...
Ahmed Uosef, Jacek Z. Kubiak, Rafik M. Ghobrial   +2 more
doaj   +2 more sources

Activation and Regulation of Indirect Alloresponses in Transplanted Patients With Donor Specific Antibodies and Chronic Rejection [PDF]

Transplant International
Following transplantation, human CD4+T cells can respond to alloantigen using three distinct pathways. Direct and semi-direct responses are considered potent, but brief, so contribute mostly to acute rejection.
Sumoyee Basu, Sumoyee Basu, Caroline Dudreuilh, Caroline Dudreuilh, Sapna Shah, Sapna Shah, Alberto Sanchez-Fueyo, Alberto Sanchez-Fueyo, Giovanna Lombardi, Giovanna Lombardi, Anthony Dorling, Anthony Dorling   +11 more
doaj   +2 more sources

Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation [PDF]

Frontiers in Immunology, 2021
Chronic rejection of the renal allograft remains a major cause of graft loss. Here, we demonstrated that the remodeling of lymphatic vessels (LVs) after their broken during transplantation contributes to the antigen presenting and lymph nodes activating.
Jinwen Lin, Ying Chen, Huijuan Zhu, Kai Cheng, Huiping Wang, Xianping Yu, Mengmeng Tang, Jianghua Chen   +7 more
doaj   +2 more sources

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts

Transplantation Reports, 2018
Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen, Wenhao Chen, Xian C Li, Rafik M Ghobrial, Malgorzata Kloc   +4 more
doaj   +2 more sources

The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study [PDF]

Frontiers in Immunology
IntroductionChronic rejection is a major complication post-transplantation. Within lung transplantation, chronic rejection was considered as airway centred. Chronic Lung Allograft Dysfunction (CLAD), defined to cover all late chronic complications, makes
Tobias Heigl, Janne Kaes, Celine Aelbrecht, Jef Serré, Yoshito Yamada, Yoshito Yamada, Vincent Geudens, Anke Van Herck, Arno Vanstapel, Arno Vanstapel, Annelore Sacreas, Sofie Ordies, Anna Frick, Berta Saez Gimenez, Berta Saez Gimenez, Jan Van Slambrouck, Hanne Beeckmans, Nilüfer A. Acet Oztürk, Nilüfer A. Acet Oztürk, Michaela Orlitova, Annemie Vaneylen, Sandra Claes, Dominique Schols, Greetje Vande Velde, Jonas Schupp, Jonas Schupp, Naftali Kaminski, Markus Boesch, Hannelie Korf, Schalk van der Merwe, Schalk van der Merwe, Lieven Dupont, Jeroen Vanoirbeek, Laurent Godinas, Dirk E. Van Raemdonck, Wim Janssens, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, John E. McDonough, John E. McDonough, Erik K. Verbeken, Robin Vos, Bart M. Vanaudenaerde   +42 more
doaj   +2 more sources

Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing Preservation Solution and Adequate Immunosuppression in a Miniature Pig Model [PDF]

Frontiers in Immunology, 2021
In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors.
Kotaro Nishi, Satomi Iwai, Kazuki Tajima, Kazuki Tajima, Shozo Okano, Motoaki Sano, Eiji Kobayashi   +6 more
doaj   +2 more sources