Results 41 to 50 of about 2,127,841 (292)

Chronic allograft rejection [PDF]

Current Opinion in Organ Transplantation, 2015
New developments suggest that the graft itself and molecules expressed within the graft microenvironment dictate the phenotype and evolution of chronic rejection.Once ischemia-reperfusion injury, cellular and humoral immune responses target the microvasculature, the associated local tissue hypoxia results in hypoxia-inducible factor 1α-dependent ...
Johannes, Wedel, Sarah, Bruneau, Nora, Kochupurakkal, Leo, Boneschansker, David M, Briscoe   +4 more
openaire   +2 more sources

Differentiation of acute versus chronic skin rejection in a rodent model of vascularized composite allotransplantation

Frontiers in Immunology
BackgroundVascularized composite allografts (VCA) have evolved to be a potential option in complex reconstructive surgery. However, managing acute and chronic allograft rejection remains challenging.
Julia Thomé, Maike Lind, Maxime Schmitt, Laura Schneider, Jurij Kiefer, Jurij Kiefer, Rebecca Schäfer, Emma Freise, Thierry Christmann, Sheena Kreuzaler, Branislav Kollár, Steffen U. Eisenhardt   +11 more
doaj   +1 more source

Impact of Lung Function Decline on Mortality in Lung Transplant Recipients: Long-Term Results From the L-CsA-i Study for the Prevention of Bronchiolitis Obliterans Syndrome

Frontiers in Medicine, 2022
BackgroundChronic lung allograft dysfunction (CLAD) is defined by a progressive loss of FEV1 and is associated with premature mortality. The aim of this study was to investigate the direct association between FEV1 decline and risk of mortality in ...
Nikolaus Kneidinger, Alessandro Ghiani, Katrin Milger, Víctor Monforte, Christiane Knoop, Peter Jaksch, Jasvir Parmar, Piedad Ussetti, Amparo Solé, Joachim Müller-Quernheim, Andreas Voelp, Juergen Behr, Claus Neurohr   +12 more
doaj   +1 more source

Alloimmunity and autoimmunity in chronic rejection [PDF]

Current Opinion in Organ Transplantation, 2010
Recent studies demonstrate an increasing role for alloimmune responses in the disruption of self-tolerance leading to immune responses to self-antigens that play a role in the immunopathogenesis of chronic rejection following solid organ transplantation.
Anil, Seetharam, Venkataswarup, Tiriveedhi, T, Mohanakumar   +2 more
openaire   +2 more sources

Exploring expressions of abandonment and rejection that emerged from group therapy with fibromyalgia patients [PDF]

, 2003
Bibliography: leaves 195-200.Fibromyalgia is a complex syndrome of diffuse pain associated with non-restorative sleep, fatigue, numerous tender points, depression and other conditions that often does not respond well to treatment posing a dilemma to ...
Van der Walt, Ria
core   +1 more source

Current status of xenotransplantation research and the strategies for preventing xenograft rejection

Frontiers in Immunology, 2022
Transplantation is often the last resort for end-stage organ failures, e.g., kidney, liver, heart, lung, and pancreas. The shortage of donor organs is the main limiting factor for successful transplantation in humans.
Qiao Zhou, Qiao Zhou, Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, Shaoping Deng, Shaoping Deng, Shaoping Deng, Chunming Cheng, Yi Wang   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Early risk factors for chronic rejection after lung transplantation [PDF]

, 2006
Chronic rejection of the lungs, characterized by bronchiolitis obliterans (BO), is the major threat for long-term function and survival of clinical lung grafts. BO is an ongoing fibroproliferative process of the airways with inflammmation and fibrosis of
Zweers, Noëlle
core   +4 more sources

Chronic alloantibody mediated rejection [PDF]

Seminars in Immunology, 2012
Alloantibodies clearly cause acute antibody mediated rejection, and all available evidence supports their pathogenic etiology in the development of chronic alloantibody mediated rejection (CAMR). But the slow evolution of this disease, the on-going immunosuppression, the variations in titer of alloantibodies, and variation in antigenic targets all ...
R Neal, Smith, Robert B, Colvin
openaire   +2 more sources

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source