Results 51 to 60 of about 2,127,841 (292)

NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection

Transplant International
Chronic graft rejection represents a significant threat to long-term graft survival. Early diagnosis, understanding of the immunological mechanisms and appropriate therapeutic management are essential to improve graft survival and quality of life for ...
Mathilde Chambon, Alice Koenig, Alice Koenig, Alice Koenig   +3 more
doaj   +1 more source

Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts

Frontiers in Immunology, 2022
Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin.
Saidou Balam, Simone Buchtler, Frederike Winter, Frederike Winter, Kathrin Schmidbauer, Sophia Neumayer, Yvonne Talke, Kerstin Renner, Edward K. Geissler, Matthias Mack, Matthias Mack   +10 more
doaj   +1 more source

Incidence, risk factors, and outcome of chronic rejection during antiviral therapy for posttransplant recurrent hepatitis C

, 2009
Antiviral therapy for recurrent hepatitis C in liver transplantation has been associated with the development of chronic rejection. The aim of this study was to assess the incidence, evolution, and risk factors associated with the development of chronic ...
Ulloa, Esperanza, Colina Ruiz-Delgado, Francisco, Moreno González, Enrique, Abradelo De Usera, Manuel, Gimeno, Alberto, Meneu Díaz, Juan Carlos, Solís Herruzo, José Antonio, Fernández Vázquez, María Inmaculada, Lumbreras Bermejo, Carlos Juan, Jiménez Romero, Luis Carlos, Esperanza Ulloa, José Antonio Solís-Herruzo, Alberto Gimeno, Francisco Colina, Carlos Jiménez, Juan Carlos Meneu, Carlos Lumbreras, Manuel Abradelo, Enrique Moreno, Inmaculada Fernández   +19 more
core   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Chronic rejection of mouse kidney allografts

, 1999
Chronic rejection of mouse kidney allografts.BackgroundChronic renal allograft rejection is the leading cause of late graft failure. However, its pathogenesis has not been defined.MethodsTo explore the pathogenesis of chronic rejection, we studied a ...
Kopp, Jeffrey B, Coffman, Thomas M, Klotman, Paul E, Mannon, Roslyn B, Platt, Jeffrey L, Bustos, Matilde, Ruiz, Philip, Griffiths, Robert   +7 more
core   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Experimental diabetes exacerbates skin transplant rejection in rats [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To investigate the effect of chronic experimental diabetes on skin allografts in rats as a simple model that could clarify some basic aspects and mechanisms involved in transplant rejection in diabetes compared to normal animals.
Flávio Pola dos Reis, Angelo Sementilli, Antonio Ricardo de Toledo Gagliardi   +2 more
doaj   +3 more sources

Association between a Single Donor TARC/CCL17 Promotor Polymorphism and Obstructive Chronic Lung Allograft Dysfunction after Lung Transplantation

Frontiers in Immunology, 2017
Lung transplantation (LTx) outcome is hampered by development of chronic rejection, often manifested as the bronchiolitis obliterans syndrome (BOS). Low serum levels of thymus and activation-regulated chemokine (TARC/CCL17), a chemoattractant, measured ...
Kevin Budding, Jessica van Setten, Eduard A. van de Graaf, Oliver A. van Rossum, Tineke Kardol-Hoefnagel, Erik-Jan D. Oudijk, C. Erik Hack, C. Erik Hack, C. Erik Hack, Henderikus G. Otten   +9 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Overcoming skin rejection in composite tissue allotransplantation [PDF]

, 2008
The application of composite tissue techniques is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the ...
Horner, B., Horner, R.
core