Results 11 to 20 of about 2,127,841 (292)

The common rejection module in chronic rejection post lung transplantation. [PDF]

PLoS ONE, 2018
RATIONALE:Recent studies suggest that similar injury mechanisms are in place across different solid organ transplants, resulting in the identification of a common rejection module (CRM), consisting of 11 genes that are overexpressed during acute and, to ...
Annelore Sacreas, Joshua Y C Yang, Bart M Vanaudenaerde, Tara K Sigdel, Juliane M Liberto, Izabella Damm, Geert M Verleden, Robin Vos, Stijn E Verleden, Minnie M Sarwal   +9 more
doaj   +2 more sources

Therapies for Chronic Allograft Rejection [PDF]

Frontiers in Pharmacology, 2021
Remarkable advances have been made in the pathophysiology, diagnosis, and treatment of antibody-mediated rejection (ABMR) over the past decades, leading to improved graft outcomes.
Min Young Kim, Daniel C. Brennan
doaj   +3 more sources

From Transplant to Reamputation: A Case Report on Chronic Rejection and Innovative Treatment in Hand Allotransplantation [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. Vascularized composite allotransplantation provides upper limb amputation patients with functional and aesthetic restoration but is limited by the challenges of chronic rejection.
Ahmed Elsaftawy, MD, PhD, Marta Jagosz, MD, Maja Smorąg, MD, Piotr Węgrzyn, MD, Dorota Kamińska, MD, PhD, Michał Bonczar, MS, Patryk Ostrowski, MS   +6 more
doaj   +2 more sources

Where Are All the Clinical Trials for Chronic Rejection? [PDF]

Transplantation
: Chronic rejection is arguably the main obstacle to long-term graft survival. Yet, clinical trials focusing on this condition are disappointingly scarce. Significant advances in treating chronic rejection cannot happen if there is no conduit for testing
Cravedi P, Maggiore U, Molinari P, Levitsky J, Zorn E.   +4 more
europepmc   +2 more sources

Allograft or Recipient ST2 Deficiency Oppositely Affected Cardiac Allograft Vasculopathy via Differentially Altering Immune Cells Infiltration

Frontiers in Immunology, 2021
The role of IL-33/ST2 signaling in cardiac allograft vasculopathy (CAV) is not fully addressed. Here, we investigated the role of IL-33/ST2 signaling in allograft or recipient in CAV respectively using MHC-mismatch murine chronic cardiac allograft ...
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Zheng Tan, Feili Gong, Fang Zheng, Fang Zheng   +14 more
doaj   +1 more source

Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury [PDF]

, 2012
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P., Johnston, Olwyn, Slattery, Craig, Cassidy, Hilary, McMorrow, Tara   +4 more
core   +2 more sources

Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice

Frontiers in Immunology, 2021
Allograft rejection is a common immunological feature in renal transplantation and is associated with reduced graft survival. A mouse renal allograft rejection model was induced and single-cell RNA sequencing (scRNA-seq) data of CD45+ leukocytes in ...
Qixia Shen, Qixia Shen, Qixia Shen, Qixia Shen, Yucheng Wang, Yucheng Wang, Yucheng Wang, Jiaoyi Chen, Lifeng Ma, Xiaoru Huang, Xiaoru Huang, Sydney C. W. Tang, Huiyao Lan, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen   +18 more
doaj   +1 more source

Immune Checkpoints Expression in Chronic Lung Allograft Rejection

Frontiers in Immunology, 2021
Chronic lung allograft dysfunction (CLAD) is the main cause of poor survival and low quality of life of lung transplanted patients. Several studies have addressed the role of dendritic cells, macrophages, T cells, donor specific as well as anti-HLA ...
Ilaria Righi, Valentina Vaira, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Francesco Blasi, Stefano Ferrero, Stefano Ferrero, Mario Nosotti, Mario Nosotti, Lorenzo Rosso, Lorenzo Rosso, Mario Clerici, Mario Clerici   +16 more
doaj   +1 more source

Tolerance and chronic rejection [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
The most common cause of chronic allograft loss is an incompletely understood clinicopathological entity called chronic rejection (CR). Recent reports suggest an improvement in long–term renal allograft survival, although it is not clear from these data whether a true reduction of biopsy–proven CR has occurred.
K L, Womer, R S, Lee, J C, Madsen, M H, Sayegh   +3 more
openaire   +2 more sources

Cold Ischemia Time and Graft Fibrosis Are Associated with Autoantibodies after Pediatric Liver Transplantation: A Retrospective Cohort Study of the European Reference Network TransplantChild

Children, 2022
The reported prevalence of autoantibodies (AAB) (ANA, SMA, LKM, SLA) after pediatric liver transplantation (pLTX) varies considerably from 26–75%, but their clinical impact on outcome is uncertain.
Norman Junge, Angelo Di Giorgio, Muriel Girard, Zeynep Demir, Diana Kaminska, Maria Janowska, Vaidotas Urbonas, Dominykas Varnas, Giuseppe Maggiore, Tommaso Alterio, Christoph Leiskau, Florian W. R. Vondran, Nicolas Richter, Lorenzo D’Antiga, Rafael Mikolajczyk, Eva-Doreen Pfister, Ulrich Baumann   +16 more
doaj   +1 more source