Results 101 to 110 of about 2,127,841 (292)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Epigenetic regulation in transplant rejection and tolerance: mechanisms and therapeutic prospects

Frontiers in Cardiovascular Medicine
Epigenetics modulates gene expression and plays a pivotal role in numerous immune disorders. Over the past two decades, increasing evidence has indicated that epigenetic regulation contributes to transplant rejection and immune tolerance.
Yuhao Li, Yuhao Li, Shuan Ran, Shuan Ran, Yanqiang Zou, Yanqiang Zou, JiKai Cui, JiKai Cui, JiKai Cui   +8 more
doaj   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

A modified mouse heart transplant model with extended aorta enables analysis of vascular continuity in cardiac allograft vasculopathy

JHLT Open
Background: Cardiac allograft vasculopathy (CAV) is a major cause of late graft failure after heart transplantation, but its spatial distribution across the donor vasculature and underlying disease progression remain incompletely defined.
Hao Dun, MD, Maura Sticco-Ivins, Gianni Bonnici, Sariah Hyacinth, Samantha L. Nelson, Dana Arenz, MD, Jordan RH Hoffman, MD, Benjamin J. Kopecky, MD, PhD   +7 more
doaj   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts

Transplantation Reports, 2018
Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen, Wenhao Chen, Xian C Li, Rafik M Ghobrial, Malgorzata Kloc   +4 more
doaj   +1 more source

Upregulation of endothelin converting enzyme-1 in host liver during chronic cardiac allograft rejection

, 2006
Endothelin regulates cytokine expression in vitro and in vivo. This study investigated the effects of chronic allograft rejection on hepatic endothelin-converting enzyme-1 (ECE-1) gene expression and endothelin-1 (ET-1) plasma clearance.
Lattmann, Thomas, Horber, Sibylle, Hein, Marc, Ortmann, Jana, Shaw, Sidney G, Shaw, Signey G., Barton, Matthias   +6 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Transition from Transbronchial Forceps to Cryobiopsy After Lung Transplantation: A Single-Centre Experience

Life
The gold standard for histological acute cellular rejection diagnosis is transbronchial forceps biopsy (FB), but in recent years, transbronchial cryobiopsy (CB) has been increasingly used.
Davide Tosi, Margherita Brivio, Sara Franzi, Alessandro Palleschi, Gianluca Bonitta, Gianluca Lopez, Ilaria Righi, Paolo Mendogni, Margherita Cattaneo, Francesco Damarco, Letizia Morlacchi, Valeria Rossetti, Lorenzo Rosso   +12 more
doaj   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source