Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]
, 2013 Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Briggs, David, Dr. +11 more
core +5 more sources
Frontiers in Immunology, 2021 Donor-specific antibodies (DSAs) play a key role in chronic kidney allograft injury. Follicular T helper (Tfh) cells trigger the humoral alloimmune response and promote DSA generation, while T-follicular regulatory (Tfr) cells inhibit antibody production
Yeqi Nian +18 more
doaj +1 more source
Clinics, 2016 OBJECTIVE: Chronic rejection remains a major cause of graft failure with indication for re-transplantation. The incidence of chronic rejection remains high in the pediatric population.
Ana Cristina Aoun Tannuri +4 more
doaj +1 more source
Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]
, 1988 A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini +25 more
core +1 more source
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]
, 2017 Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L +3 more
core +4 more sources
Chronic allograft rejection: A significant hurdle to transplant success
Burns & Trauma, 2014 The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation.
Malgorzata Kloc, Rafik M Ghobrial
doaj +1 more source
Chronic rejection occurring early post liver transplant
Indian Journal of Transplantation, 2023 We report the case of a 36-year-old male who was referred to us with a provisional diagnosis of ethanol-related acute on chronic liver failure with ascites, encephalopathy, and altered liver function tests (LFTs).
Nalini Bansal +3 more
doaj +1 more source
Reduced CD40L expression on ex vivo activated CD4+T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure [PDF]
, 2004 Background: The CD40-CD40L (CD154) costimulatory pathway plays a critical role in the pathogenesis of kidney allograft rejection. In renal transplant biopsies, CD4+ CD40L+ graft-infiltrating cells were detected during chronic rejection in contrast to ...
Friedrich, N. +5 more
core +1 more source
Experimental diabetes exacerbates skin transplant rejection in rats [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: To investigate the effect of chronic experimental diabetes on skin allografts in rats as a simple model that could clarify some basic aspects and mechanisms involved in transplant rejection in diabetes compared to normal animals.
Flávio Pola dos Reis +2 more
doaj +3 more sources
LATE RENAL GRAFT REJECTION: PATHOLOGY AND PROGNOSIS
Вестник трансплантологии и искусственных органов, 2014 Rejection has always been one of the most important cause of late renal graft dysfunction. Aim of the study was to analyze the prevalence of different clinico-pathological variants of rejection that cause late graft dysfunction, and evaluate their impact
E.S. Stolyarevich +4 more
doaj +1 more source