Results 71 to 80 of about 3,296,949 (379)

Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts

Frontiers in Immunology, 2022
Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin.
Saidou Balam, Simone Buchtler, Frederike Winter, Frederike Winter, Kathrin Schmidbauer, Sophia Neumayer, Yvonne Talke, Kerstin Renner, Edward K. Geissler, Matthias Mack, Matthias Mack   +10 more
doaj   +1 more source

Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants

Nature Communications, 2019
Current doctrine is that microvascular inflammation (MVI) triggered by a transplant -recipient antibody response against alloantigens (antibody-mediated rejection) is the main cause of graft failure.
A. Koenig, Chien-Chia Chen, A. Marçais, T. Barba, V. Mathias, A. Sicard, M. Rabeyrin, M. Racapé, Jean-Paul Duong-Van-Huyen, P. Bruneval, A. Loupy, S. Dussurgey, S. Ducreux, V. Meas-Yedid, Jean-Christophe Olivo-Marin, H. Paidassi, R. Guillemain, J. Taupin, J. Callemeyn, E. Morelon, A. Nicoletti, B. Charreau, V. Dubois, M. Naesens, T. Walzer, T. Defrance, O. Thaunat   +26 more
semanticscholar   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Chronic transplant rejection

Kidney International, 1994
A 30-year-old woman was admitted to the University of Minnesota Hospital to receive a second cadaveric renal transplant. Eighteen years earlier, she had received her first cadavenc renal transplant for renal failure due to chronic glomerulonephritis.
openaire   +2 more sources

Pathogenesis of chronic allograft rejection [PDF]

Transplant International, 2003
Chronic allograft nephropathy (CAN) is, besides death of the recipient with graft function, the most common cause of renal transplant loss. It is characterized by loss of function and replacement of tissue by fibrotic material. The pathogenesis is not clear, but seems to be multifactorial and involves events both early and late after transplantation ...
Simone A, Joosten, Cees, van Kooten, Leendert C, Paul   +2 more
openaire   +2 more sources

NK Cells: Not Just Followers But Also Initiators of Chronic Vascular Rejection

Transplant International
Chronic graft rejection represents a significant threat to long-term graft survival. Early diagnosis, understanding of the immunological mechanisms and appropriate therapeutic management are essential to improve graft survival and quality of life for ...
Mathilde Chambon, Alice Koenig, Alice Koenig, Alice Koenig   +3 more
doaj   +1 more source

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor

Frontiers in Immunology, 2021
CD4+CD25+Foxp3+T cell population is heterogenous and contains three major sub-groups. First, thymus derived T regulatory cells (tTreg) that are naïve/resting. Second, activated/memory Treg that are produced by activation of tTreg by antigen and cytokines.
Bruce M. Hall, Bruce M. Hall, Rachael M. Hall, Rachael M. Hall, Giang T. Tran, Giang T. Tran, Catherine M. Robinson, Catherine M. Robinson, Paul L. Wilcox, Paul L. Wilcox, Prateek K. Rakesh, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson   +17 more
doaj   +1 more source

RT‐PCR–Based Detection of Bone Marrow Involvement in Ewing Sarcoma: Diagnostic Validity and Prognostic Relevance

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background In Ewing sarcoma (EwS), metastases, including those to bone marrow (BM), are the main factors influencing prognosis. Although reverse transcription polymerase chain reaction (RT‐PCR) offers greater sensitivity, the current EWING protocol defines BM metastases solely using light microscopic detection.
Thanh Pham, Andreas Ranft, Victor Rechl, Susanne Jabar, Wolfgang Hartmann, Kim Falkenberg, Heribert Jürgens, Norbert Graf, Torsten Keßler, Markus Metzler, Thomas Klingebiel, Thorsten Simon, Martin Benesch, Uta Dirksen   +13 more
wiley   +1 more source

Impact of Lung Function Decline on Mortality in Lung Transplant Recipients: Long-Term Results From the L-CsA-i Study for the Prevention of Bronchiolitis Obliterans Syndrome

Frontiers in Medicine, 2022
BackgroundChronic lung allograft dysfunction (CLAD) is defined by a progressive loss of FEV1 and is associated with premature mortality. The aim of this study was to investigate the direct association between FEV1 decline and risk of mortality in ...
Nikolaus Kneidinger, Alessandro Ghiani, Katrin Milger, Víctor Monforte, Christiane Knoop, Peter Jaksch, Jasvir Parmar, Piedad Ussetti, Amparo Solé, Joachim Müller-Quernheim, Andreas Voelp, Juergen Behr, Claus Neurohr   +12 more
doaj   +1 more source

Intrahepatic bile duct strictures after human orthotopic liver transplantation - Recurrence of primary sclerosing cholangitis or unusual presentation of allograft rejection? [PDF]

, 1988
One of 55 patients transplanted for sclerosing cholangitis during the cyclosporin-steroid era (March 1980-June 1986) developed intrahepatic biliary strictures in the absence of allograft rejection within the 1st year posttransplantation.
A. C. Stieber, A. J. Demetris, AJ Demetris, B Portmann, C. O. Esquivel, J Lerut, J Neuberger, J. Lerut, J. W. Marsh, JW Marsh, KA Porter, R. D. Gordon, RH Fennell, S Iwatsuki, S. Iwatsuki, T. E. Starzl, TE Starzl   +16 more
core   +1 more source