Results 51 to 60 of about 616,808 (306)

Anaemia in chronic respiratory failure. [PDF]

International journal of clinical practice, 2011
In patients with severe chronic obstructive pulmonary disease (COPD), anaemia is common and associated with impaired long-term survival and quality of life. Whether anaemia is also prevalent in patients with other severe, non-inflammatory respiratory diseases has not yet been systematically tested.In 595 patients with obstructive (OD, 54.8%) or ...
F, Kollert, C, Müller, A, Tippelt, R A, Jörres, D, Heidinger, C, Probst, M, Pfeifer, S, Budweiser   +7 more
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Highlights from the Respiratory Failure and Mechanical Ventilation 2020 Conference

ERJ Open Research, 2021
The Respiratory Intensive Care Assembly of the European Respiratory Society organised the first Respiratory Failure and Mechanical Ventilation Conference in Berlin in February 2020.
Adelaide Withers, Tiffany Choi Ching Man, Rebecca D'Cruz, Heder de Vries, Christoph Fisser, Carla Ribeiro, Neeraj Shah, Marine Van Hollebecke, Bettine A.H. Vosse, Leo Heunks, Maxime Patout   +10 more
doaj   +1 more source

Cardiac safety of tiotropium in patients with cardiac events: a retrospective analysis of the UPLIFT® trial. [PDF]

, 2015
BackgroundTiotropium is an anticholinergic bronchodilator for symptom relief and reducing exacerbations with an established safety profile in patients with chronic obstructive pulmonary disease (COPD).
Decramer, Marc, Leimer, Inge, Metzdorf, Norbert, Tashkin, Donald P   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comments on “Post-extubation high-flow nasal cannula oxygen therapy versus non-invasive ventilation in chronic obstructive pulmonary disease with hypercapnic respiratory failure”

Monaldi Archives for Chest Disease, 2023
Dear Editor, The recent study published by Ketan et al. provides emerging evidence on the expanding indications for high-flow nasal oxygen (HFNO) therapy in chronic obstructive pulmonary disease (COPD).
Vidushi Rathi
doaj   +1 more source

Predictors of Successful Decannulation Using a Tracheostomy Retainer in Patients with Prolonged Weaning and Persisting Respiratory Failure [PDF]

, 2012
Background: For percutaneously tracheostomized patients with prolonged weaning and persisting respiratory failure, the adequate time point for safe decannulation and switch to noninvasive ventilation is an important clinical issue.
Abboussouan LS, Aboussouan LS, Bach JR, Boles JM, Ceriana P, Divo MJ, Durbin, Engoren M, Epstein SK, Florian Kollert, Frank Heinemann, Franke KJ, Griffiths J, Gursel GG, Heffner JE, Hess DR, Hsu CL, Kornblith LZ, Le Gall JR, MacIntyre NR, Marchese S, Marchese S, Michael Pfeifer, O’Connor HH, O’Connor HH, Rudolf A. Jörres, Schönhofer B, Stelfox HT, Stephan Budweiser, Tobias Baur, Wu YK   +30 more
core   +2 more sources

Respiratory Patterns and Chronic Heart Failure [PDF]

Circulation, 1998
To the Editor: A primary rhythm in the central nervous system that entrains both heart rate, blood pressure, and ventilation1 is suggested by profound effects on angina through consciously focusing on breathing and intervening pauses; adaptation to stress manifested by slower, …
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source