Results 161 to 170 of about 408,452 (313)

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Acute and Chronic Toxicity of Sediments Containing Platinum and Palladium on Freshwater Benthic Organisms Chironomus riparius and Hyalella azteca. [PDF]

J Appl Toxicol
Carle A, Preizal L, Amyot M, Rosabal M.
europepmc   +1 more source

Acute and Chronic Toxicity of Binary Mixtures of Bisphenol A and Heavy Metals. [PDF]

Toxics, 2022
Yang J, Liao A, Hu S, Zheng Y, Liang S, Han S, Lin Y.   +6 more
europepmc   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

<i>In vivo</i> safety prediction of recombinant collagen using <i>in vitro</i> simulated degradation analysis, chronic toxicity and immunological evaluation. [PDF]

Regen Biomater
Huang C, Li J, Aou X, He H, Chu Y, Gao J, Le H, Wang X, Sun H, Wang H, Zhu Z, Fan Y, Zhang G, Fan X, Yuan T.   +14 more
europepmc   +1 more source

Chemical Composition and Chronic Toxicity of Disc-Cultured Antrodia cinnamomea Fruiting Bodies. [PDF]

Toxics, 2022
Liu SC, Wu TY, Hsu TH, Lai MN, Wu YC, Ng LT.   +5 more
europepmc   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Assessment of sub-chronic toxicity and anti-aging effects of a solid self-microemulsifying drug delivery system of <i>Kaempferia parviflora</i> extract in a D-galactose-induced rat model. [PDF]

Pharm Biol
Somintara S, Sakaew W, Tuntiyasawasdikul S, Tabboon P, Mekjaruskul C, Phanphak J, Pariwatthanakun C, Sripanidkulchai B, Rudtanatip T.   +8 more
europepmc   +1 more source

ASSESSMENT OF THE IMPACT OF A COMPLEX OF TOXIC SUBSTANCES ON THE MORPHOLOGICAL STATE OF INTERNAL ORGANS IN A CHRONIC EXPERIMENT ON ANIMALS

O. A. Savchenko, Irina I. Novikova, P. E. Svechkar, О. А. Савченко   +3 more
openalex   +1 more source

Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats [PDF]

, 2002
Barry L. Yano
openalex   +1 more source