Results 21 to 30 of about 408,452 (313)

Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods.
A. A. Churin, E. Y. Sherstoboev, D. N. Kinsht, T. S. Tartynova, P. G. Madonov   +4 more
doaj   +1 more source

Organophosphorus flame retardants – Toxicity and influence on human health

Medycyna Pracy, 2015
Organophosphorus flame retardants (flame retardants, FRs) have been used for several decades in many industries, including the production of dyes, varnishes, adhesives, synthetic resins, polyvinyl chloride, hydraulic fluids, plastics and textiles.
Elżbieta Bruchajzer, Barbara Frydrych, Jadwiga Anna Szymańska   +2 more
doaj   +1 more source

Theoretical Calculation on the Reaction Mechanisms, Kinetics and Toxicity of Acetaminophen Degradation Initiated by Hydroxyl and Sulfate Radicals in the Aqueous Phase

Toxics, 2021
The •OH and SO4•− play a vital role on degrading pharmaceutical contaminants in water. In this paper, theoretical calculations have been used to discuss the degradation mechanisms, kinetics and ecotoxicity of acetaminophen (AAP) initiated by •OH and SO4•−
Mengmeng Xu, Junfang Yao, Simei Sun, Suding Yan, Jingyu Sun   +4 more
doaj   +1 more source

Durian fruit pulp extract enhances intracellular glutathione levels, mitigating oxidative stress and inflammation for neuroprotection

Scientific Reports
Durian (Durio zibethinus L.) fruit pulp is a rich source of γ-glutamylcysteine (γ-EC), a direct precursor to the antioxidant glutathione (GSH). This study elucidated the in vitro neuroprotective potential of unripe durian fruit pulp extract (UDE) against
Gholamreza Khaksar, Su Lwin Lwin Myint, Hasriadi, Pasarapa Towiwat, Supaart Sirikantaramas, Ratchanee Rodsiri   +5 more
doaj   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Risk Assessment of Shellfish Toxins

Toxins, 2013
Complex secondary metabolites, some of which are highly toxic to mammals, are produced by many marine organisms. Some of these organisms are important food sources for marine animals and, when ingested, the toxins that they produce may be absorbed and ...
Rex Munday, John Reeve
doaj   +1 more source

Study of acute and chronic toxicity of homeopathic syrup Stodal

Фармакокинетика и Фармакодинамика, 2020
The study of acute and chronic toxicity of the homeopathic preparation syrup Stodal, produced by the Laboratory of Boiron, France, widely used in medical practice as an effective antitussive agent.
S. V. Alekseeva, A. V. Sorokina, V. V. Zabrodina, I. A. Miroshkina, A. S. Lapitskaya   +4 more
doaj   +1 more source

The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

Journal of Pharmacopuncture, 2023
Objectives: Terminalia chebula, the main ingredient of Altan Arur 5, has been used for many years in traditional medicine. This medicine is more effective than other drugs and is used to treat chronic gastritis and gastrointestinal disorders such as ...
ARONGQIQIGE, Gerelmaa Enebish, Wang Song, Wei Cheng Xi, Anuujin Gantumur, Oyunbaatar Altanbayar, Hirofumi Shimomura, Battogtokh Chimeddorj, Batnairamdal Chuluun, Avarzed Amgalanbaatar   +9 more
doaj   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

The influence of algal densities on the toxicity of chromium for Ceriodaphnia dubia Richard (Cladocera, Crustacea)

Brazilian Journal of Biology
Food availability may affect metal toxicity for aquatic organisms. In the present study, the influence of high, medium and low densities of the algae Pseudokirchneriella subcapitata (10(6), 10(5) and 10(4) cells.mL-1, respectively) on the chronic ...
S. Rodgher, ELG. Espíndola
doaj   +1 more source