Results 41 to 50 of about 83,142 (245)

Developing and Evaluating a Laboratory‐Based Frailty Index (FI‐Lab) for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical frailty index (FI).
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Frailty in Glioblastoma Is Independent From Chronological Age

Frontiers in Neurology, 2021
Objective: Treatment of glioblastoma in elderly patients is particularly challenging due to their general condition and comorbidities. Treatment decisions are often based on chronological age.
Harald Krenzlin, Dragan Jankovic, Christoph Alberter, Darius Kalasauskas, Christiane Westphalen, Florian Ringel, Naureen Keric   +6 more
doaj   +1 more source

Assessing Chronological Aging in Saccharomyces cerevisiae [PDF]

, 2012
Saccharomyces cerevisiae is one of the most studied model organisms for the identification of genes and mechanisms that affect aging. The chronological lifespan (CLS) assay, which monitors the survival of a non-dividing population, is one of the two methods to study aging in yeast.
Jia, Hu, Min, Wei, Mario G, Mirisola, Valter D, Longo   +3 more
openaire   +2 more sources

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Determining the Difference between the Chronological and Biological Age of Athletes Diagnosed with Trigeminal Neuralgia

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae
Trigeminal neuralgia induces severe, often intolerable pain in patients—athletes, in this context—that is frequently resistant to currently available therapeutic options.
Josip MIOČIĆ, Milica KOMŠO, Tonći JERAK   +2 more
doaj   +1 more source

Crystal Engineering of Reticular Materials for Gas‐ and Liquid‐Phase Hydrocarbon Separation

Advanced Materials, EarlyView.
Crystal engineering enables systematic study of structure/function relationships as exemplified by pore engineering of reticular sorbents, including porous coordination networks and covalent organic frameworks. This review assesses such studies applied across the full scope of industrially relevant hydrocarbon separations to provide insight into how ...
Xia Li, Soumya Mukherjee, Michael J. Zaworotko   +2 more
wiley   +1 more source

Biological age as estimated by baseline circulating metabolites is associated with incident diabetes and mortality

The Journal of Nutrition, Health and Aging
Objectives: It is unclear how metabolomic assessment of biological aging performs in non-White populations and whether such an approach can predict future mortality.
La-or Chailurkit, Nisakron Thongmung, Prin Vathesatogkit, Piyamitr Sritara, Boonsong Ongphiphadhanakul   +4 more
doaj   +1 more source

CancerClock: A DNA Methylation Age Predictor to Identify and Characterize Aging Clock in Pan-Cancer

Frontiers in Bioengineering and Biotechnology, 2019
Many biological indicators related to chronological age have been proposed. Recent studies found that epigenetic clock or DNA methylation age is highly correlated with chronological age. In particular, a significant difference between DNA methylation age
Tongtong Zhu, Yue Gao, Junwei Wang, Xin Li, Shipeng Shang, Yanxia Wang, Shuang Guo, Hanxiao Zhou, Hongjia Liu, Dailin Sun, Hong Chen, Li Wang, Shangwei Ning   +12 more
doaj   +1 more source

Chronological and biological age: Why relevant for psychiatrists?

European Psychiatry, 2021
Introduction Depression is the mental disorder with the largest disease burden impact. That is due to its high prevalence, chronicty, early onset but also due to its impact on various aging-related somatic morbidities and mortality.
B. Penninx
doaj   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source