Results 51 to 60 of about 447,031 (304)

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

CancerClock: A DNA Methylation Age Predictor to Identify and Characterize Aging Clock in Pan-Cancer

Frontiers in Bioengineering and Biotechnology, 2019
Many biological indicators related to chronological age have been proposed. Recent studies found that epigenetic clock or DNA methylation age is highly correlated with chronological age. In particular, a significant difference between DNA methylation age
Tongtong Zhu, Yue Gao, Junwei Wang, Xin Li, Shipeng Shang, Yanxia Wang, Shuang Guo, Hanxiao Zhou, Hongjia Liu, Dailin Sun, Hong Chen, Li Wang, Shangwei Ning   +12 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Assessment of the relationship between body mass index, dental age, chronological age, and skeletal maturity among 6–12-year children in Pune, India

Journal of Indian Society of Pedodontics and Preventive Dentistry
Context: Growth and development in children are influenced by various factors, including genetic, environmental, and nutritional aspects. Assessing a child’s development is critical for pediatric care, particularly in understanding their dental, skeletal,
Rahul J. Hegde, Anand L. Shigli, Pritesh N. Gawali, Bhagyashree B. Mune   +3 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Activin subfamily peptides predict chronological age in humans [PDF]

, 2018
Loss of muscle mass and function are a well‐defined aspect of human aging from the 3rd decade of life, which result in reduced independence and increased mortality.
Amthor, Baccarelli, Bloom, Cruz-Jentoft, Ebert, Egerman, Elliott, Elliott, Garatachea, Gilson, Gonzalez-Cadavid, Harper, Hill, Hinck, Holland, Jiang, Kallman, Lakshman, Loffredo, Loria, McPherron, Metter, Mitchell, Poggioli, Ratkevicius, Santoro, Schulte, Seibert, Sinha, Steiber, Thies, Whittemore, Yang, Yarasheski, Zhou, Zimmers   +35 more
core   +2 more sources

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Reliability of two dental age estimation methods in children and comparison with their chronological age

Saudi Journal for Health Sciences, 2019
Background: Dental age estimation is being performed since Demirjian proposed dental maturity scores. Subsequently, numerous methods were proposed and were estimated worldwide. Although these methods showed high degrees of reliability, ethnic differences
Yasser R Souror, Harshkant P Gharote
doaj   +1 more source

The BHK Color Diagram: a New Tool to Study Young Stellar Populations [PDF]

, 1998
A new method to derive age differences between the various super star clusters observed in starburst galaxies using the two color diagram (B-H) vs (H-K) is presented.
Charbonnel D., Daniel Devost, Frogel J., Frogel J., Kumai Y., Leitherer C., Martin P., Meynet G., Satyapal S., Schaerer D., Schaerer D., Schaller G., Seiden P. E., Seiden P.E.   +13 more
core   +3 more sources

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source