Results 131 to 140 of about 4,551 (194)

Chrysophanol induces apoptosis and ferroptosis of gastric cancer cells by targeted regulation of mTOR

Chemical Biology and Drug Design
Programmed cell death (PCD) induction is a promising strategy for killing gastric cancer cells. In this study, we investigated the effects of chrysophanol on apoptosis and ferroptosis in gastric cancer cells. Chrysophanol in concentrations ranging from 0
Sujuan Xi, Wei Ding, Danping Weng, Yue-yue Zeng, Kewei Gao, Qiuye Wu, Guoping Huang, Yufang Li, Haiyan Yue   +8 more
exaly   +2 more sources

Chrysophanol: A Promising Agent in Modulating Inflammatory Pathways.

Recent Advances in Inflammation & Allergy Drug Discovery
Chrysophanol, a naturally occurring anthraquinone compound found in various plants, fungi, and lichens, has garnered increasing attention for its potential therapeutic benefits, particularly in the context of inflammation-related disorders.
Radhika Singh, Akhil Sharma, Sushma Devi
semanticscholar   +3 more sources

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics [PDF]

Journal of Pharmacy and Pharmacology, 2019
Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8‐dihydroxy‐3‐methyl‐anthraquinone. It has been widely used in the food and pharmaceutical fields.
Long Xie, Hailong Tang, Jiawen Song, Jiaying Long, Linlin Zhang, Xiaofang Li   +5 more
semanticscholar   +3 more sources

Chrysophanol delays aging via insulin/IGF-1 signaling pathway.

Free Radical Biology and Medicine
Aging is inevitable processes which play a significant role in the development of various diseases, including cardiovascular diseases, neurodegenerative disorders, and cancers.
Hongjiao Zhang, Jun Xiong, Qingyao Wang, Qiuyue Song, Lingjie Meng, Han Zhang, Yuxin Bao, Fang Liu, Yi Xiao   +8 more
semanticscholar   +3 more sources

The potential antitumor effect of chrysophanol in relation to cervical cancer cells

Journal of Cellular Biochemistry, 2021
AbstractChrysophanol is an anthraquinone with proven antitumor activity against several tumor cell lines. However, its effect on cervical cancer cells is still unknown. Therefore, HeLa cells were exposed to various concentrations of chrysophanol and then subjected to biochemical, ultrastructural, and morphological analysis. It has been shown using flow
Teodora Król, Wojciech Trybus, Ewa Trybus   +2 more
exaly   +3 more sources

Chrysophanol alleviates acute lung injury caused by Klebsiella pneumoniae infection by inhibiting pro‐inflammatory cytokine production

Phytotherapy Research, 2023
Acute lung injury (ALI) caused by acute bacterial infection remains a common life‐threatening lung disease. An increased inflammatory response is the basis for the occurrence and development of ALI. Most antibiotics can only reduce the bacterial load but
Fei Jiang, Jiebang Jiang, Wenping He, Guokai Dong, Nana Xu, Li Meng, Yunyun Zhao, Meng Wang, Shirui Tan, Yongping Shi, Rongpeng Li   +10 more
semanticscholar   +1 more source

Cytochrome P450 mediated metabolic activation of chrysophanol

Chemico-Biological Interactions, 2018
Chrysophanol, a major anthraquinone component occurring in many traditional Chinese herbs, is accepted as important active component with various pharmacological actions such as antibacterial and anticancer activity. Previous studies demonstrated that exposure to chrysophanol induced cytotoxicity, but the mechanisms of the toxic effects remain unknown.
Ying Sun, Xin Xin, Kehan Zhang, Tiantian Cui, Ying Peng, Jiang Zheng   +5 more
openaire   +2 more sources

Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in Osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis.

Biochemical Pharmacology, 2022
Osteoarthritis (OA) is a common joint illness that negatively impacts people's lives. The main active ingredient of cassia seed or rhubarb is chrysophanol.
Jiajie Lu, Zhimin Miao, Yuhan Jiang, Weiyi Xia, Xian Wang, Yi-Feng Shi, Libin Ni, Sunlong Li, Jian-wu Xiao, Sunren Sheng, Haiming Jin   +10 more
semanticscholar   +1 more source

Chrysophanol is involved in the biofertilization and biocontrol activities of Trichoderma

Physiological and Molecular Plant Pathology, 2016
Abstract The effect of chrysophanol, a secondary metabolite of Trichoderma harzianum , on the growth and disease resistance of cabbage against Botrytis cinerea was investigated. Chrysophanol assisted cabbage growth and promoted resistance against B . cinerea . Proteins related to photosynthesis were expressed in T .
Kou-Cheng Peng, Hsueh-Hui Yang, Chaur-Tsuen Lo   +2 more
exaly   +2 more sources

Synergistic interaction of physcion and chrysophanol on plant powdery mildew

Pest Management Science, 2007
Abstract The extract of the plant Rheum officinale Baill, mainly containing the anthraquinones physcion and chrysophanol, is highly active against plant powdery mildew.
Xiaojun, Yang, Lijun, Yang, Shaonan, Wang, Dazhao, Yu, Hanwen, Ni   +4 more
exaly   +3 more sources