Results 181 to 190 of about 2,511 (220)
Some of the next articles are maybe not open access.
Natural Toxins, 1992
AbstractAfter repeated ip and oral administrations of ciguatoxin (CTX) and ciguatoxin‐4c (CTX‐4c), one of the derivatives of CTX, to male ICR mice at a dose of 0.1 μg/kg for 15 days, resulted in marked swelling of cardiac cells and endothelial lining cells of blood capillaries in the heart was observed.
K, Terao, E, Ito, T, Yasumoto
openaire +2 more sources
AbstractAfter repeated ip and oral administrations of ciguatoxin (CTX) and ciguatoxin‐4c (CTX‐4c), one of the derivatives of CTX, to male ICR mice at a dose of 0.1 μg/kg for 15 days, resulted in marked swelling of cardiac cells and endothelial lining cells of blood capillaries in the heart was observed.
K, Terao, E, Ito, T, Yasumoto
openaire +2 more sources
A Concise Route to the Right Wing of Ciguatoxin.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Atsushi Tatami +3 more
openaire +1 more source
Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C
Journal of the American Chemical Society, 2006Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers with the 13 ether rings ranging from five- to nine-membered. In this paper, we describe the total synthesis of the two most toxic members of the ciguatoxin family, ciguatoxin 1 and 51-hydroxyCTX3C 2, based on a unified synthetic strategy.
Masayuki, Inoue +9 more
openaire +2 more sources
Immune effects of the neurotoxins ciguatoxins and brevetoxins
Toxicon, 2018Ciguatoxins (CTXs) and brevetoxins (PbTxs) are phycotoxins that can accumulate along the marine food chain and thus cause seafood poisoning in humans, namely "ciguatera fish poisoning" (CFP) and "neurotoxic shellfish poisoning" (NSP), respectively. CFP is characterized by early gastrointestinal symptoms and typical sensory disorders (paraesthesia, pain,
Ophelie Pierre +3 more
openaire +2 more sources
Action of mannitol in ciguatoxin-intoxicated rats
Toxicon, 1999This study reports the effects of mannitol on nerve conduction when used as a therapeutic agent in mammals following the administration of ciguatoxin. Electrophysiological studies were performed in vivo on the rat ventral coccygeal nerve. The absolute and relative refractory periods, conduction velocity and the supernormal response were measured in ...
Purcell, CE, Capra, MF, Cameron, J
openaire +3 more sources
Ciguatoxin: developing the methodology for total synthesis
Natural Product Reports, 2010Covering: up to 2009 The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.
Minoru, Isobe, Akinari, Hamajima
openaire +2 more sources
[Ciguatoxins and brevetoxins: dissection of the neurobiological actions].
Journal de la Societe de biologie, 1999This review focuses on the neurobiological actions of ciguatoxins and brevetoxins which are phycotoxins produced respectively by the dinoflagellates Gambierdiscus toxicus and Ptychodiscus brevis. These actions are illustrated in particular by the effects of the toxins on myelinated nerve fibres and on skeletal neuromuscular junctions of vertebrates ...
Mattei, César +3 more
openaire +2 more sources