Results 21 to 30 of about 2,474 (201)

Giant Moray Eel (Gymnothorax javanicus), a Long-Living Apex Predator That Poses a Food Safety Risk in the Pacific [PDF]

Marine Drugs
The giant moray eel (GME; Gymnothorax javanicus) is an important marine species that plays a key ecological role in reef systems and is a valued food source for indigenous communities.
Emillie M. F. Passfield, Kirsty F. Smith, D. Tim Harwood, Joshua D. Fitzgerald, Phoebe A. Argyle, Jacob Thomson-Laing, J. Sam Murray   +6 more
doaj   +2 more sources

Bimodal Cell Size and Fusing Cells Observed in a Clonal Culture of the Ciguatoxin-Producing Benthic Dinoflagellate Gambierdiscus (WC1/1) [PDF]

Toxins, 2022
Cells in a clonal culture of the WC1/1 strain of Gambierdiscus that produced ciguatoxin and maitotoxin-3 were observed to spontaneously fuse during the light phase of culture growth.
Michael J. Holmes, Richard J. Lewis
doaj   +2 more sources

A General Food Chain Model for Bioaccumulation of Ciguatoxin into Herbivorous Fish in the Pacific Ocean Suggests Few Gambierdiscus Species Can Produce Poisonous Herbivores, and Even Fewer Can Produce Poisonous Higher Trophic Level Fish [PDF]

Toxins
We adapt previous conceptual and numerical models of ciguateric food chains for the bioaccumulation of Pacific-ciguatoxin-1 (P-CTX-1) to a general model for bioaccumulation of P-CTX3C by parrotfish (Scarus frenatus, S. niger, and S.
Michael J. Holmes, Richard J. Lewis
doaj   +2 more sources

Synthesis of the A-F Fragment of the Pacific Ciguatoxin CTX3C by Iterative Ring-Closing Metathesis and Tsuji-Trost Allylation. [PDF]

Chemistry, 2023
The fully functionalized A−F ring system of the Pacific ciguatoxin CTX3C suitable for coupling to the I−M fragment of the natural product, has been synthesized from a simple glucal derivative. A six‐step sequence that features ring‐closing metathesis and stereoselective palladium‐mediated allylation has been deployed in an iterative manner to construct
Triantafyllakis M, Alexander S, Woolford S, Wilson C, Clark JS.   +4 more
europepmc   +2 more sources

Faster ciguatoxin extraction methods for toxicity screening [PDF]

Scientific Reports
Ciguatera poisoning (CP) is a severe global public health problem caused by the consumption of seafood products contaminated with ciguatoxins (CTXs). The growing demand for seafood products requires high-throughput testing for CTX-susceptible seafood ...
Christopher R. Loeffler, Astrid Spielmeyer   +1 more
doaj   +2 more sources

Toxicity Screening of a Gambierdiscus australes Strain from the Western Mediterranean Sea and Identification of a Novel Maitotoxin Analogue

Marine Drugs, 2021
Dinoflagellate species of the genera Gambierdiscus and Fukuyoa are known to produce ciguatera poisoning-associated toxic compounds, such as ciguatoxins, or other toxins, such as maitotoxins.
Pablo Estevez, David Castro, José Manuel Leão-Martins, Manoëlla Sibat, Angels Tudó, Robert Dickey, Jorge Diogene, Philipp Hess, Ana Gago-Martinez   +8 more
doaj   +1 more source

Ciguatoxin-Producing Dinoflagellate Gambierdiscus in the Beibu Gulf: First Report of Toxic Gambierdiscus in Chinese Waters

Toxins, 2021
Ciguatera poisoning is mainly caused by the consumption of reef fish that have accumulated ciguatoxins (CTXs) produced by the benthic dinoflagellates Gambierdiscus and Fukuyoa.
Yixiao Xu, Xilin He, Wai Hin Lee, Leo Lai Chan, Douding Lu, Pengbin Wang, Xiaoping Tao, Huiling Li, Kefu Yu   +8 more
doaj   +1 more source

Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in Fishes

Toxins, 2021
We review and develop conceptual models for the bio-transfer of ciguatoxins in food chains for Platypus Bay and the Great Barrier Reef on the east coast of Australia.
Michael J. Holmes, Bill Venables, Richard J. Lewis   +2 more
doaj   +1 more source

An Extensive Survey of Ciguatoxins on Grouper Variola louti from the Ryukyu Islands, Japan, Using Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)

Journal of Marine Science and Engineering, 2022
Ingesting fish contaminated with ciguatoxins (CTXs) originating from epibenthic dinoflagellates causes ciguatera fish poisoning (CFP). CFP occurs mainly in the tropical and subtropical Indo–Pacific region and the Caribbean Sea.
Naomasa Oshiro, Hiroya Nagasawa, Miharu Watanabe, Mio Nishimura, Kyoko Kuniyoshi, Naoki Kobayashi, Yoshiko Sugita-Konishi, Hiroshi Asakura, Katsunori Tachihara, Takeshi Yasumoto   +9 more
doaj   +1 more source

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1 [PDF]

, 2017
Human intoxication with the seafood poison ciguatoxin, a dinoflagellate polyether that activates voltage-gated sodium channels (NaV), causes ciguatera, a disease characterised by gastrointestinal and neurological disturbances. We assessed the activity of
Brierley, S., Caldwell, A., Castro, J., Deuis, J., Erickson, A., Garcia-Caraballo, S., Grundy, L., Harrington, A., Inserra, M., Israel, M., Keramidas, A., Lewis, R., Maddern, J., Rychkov, G., Vetter, I., Zimmermann, K.   +15 more
core   +3 more sources