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An investigation into ciguatoxin bioaccumulation in sharks
Toxicon, 2016Ciguatoxins (CTXs) produced by benthic Gambierdiscus dinoflagellates, readily biotransform and bioaccumulate in food chains ultimately bioconcentrating in high-order, carnivorous marine species. Certain shark species, often feeding at, or near the top of the food-chain have the ability to bioaccumulate a suite of toxins, from both anthropogenic and ...
Lauren Meyer +3 more
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Ciguatoxin: Isolation and Chemical Nature
Science, 1967Ciguatoxin, the agent responsible for ciguatera, a disease produced in humans from ingestion of certain fishes, has been isolated from specimens of the moray eel, Gymnothorax javanicus . The toxin is apparently a lipid containing quaternary nitrogen, hydroxyl, and carbonyl functions.
P J, Scheuer +3 more
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Two interchangeable forms of ciguatoxin
Toxicon, 1984Ciguatoxin, the principal toxin responsible for ciguatera, isolated from moray eel viscera, has been separated into two distinct components by alumina chromatography. A series of chromatographies showed that the two components are interchangeable. This proves that ciguatoxin is a single molecular entity.
M, Nukina, L M, Koyanagi, P J, Scheuer
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Total Synthesis of Ciguatoxin CTX3C
Science, 2001More than 20,000 people suffer annually from ciguatera seafood poisoning in subtropical and tropical regions. The extremely low content of the causative neurotoxins, designated as ciguatoxins, in fish has hampered the isolation, detailed biological studies, and preparation of anti-ciguatoxin antibodies for detecting these toxins.
M, Hirama +6 more
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Polyneuropathy secondary to ciguatoxin poisoning
The Italian Journal of Neurological Sciences, 1988Following ingestion of marine fish in Thailand this patient complained of gastrointestinal and neurological disturbances, marked by severe, mainly motor, demyelinating polyneuropathy, which worsened on her return to Italy a few days later. The clinical pattern, electromyography, cerebrospinal fluid test and sural nerve biopsy by electronmicroscopy ...
Sozzi, G +4 more
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Optimization of ciguatoxin extraction method from blood for Pacific ciguatoxin (P-CTX-1)
Toxicon, 2007Ciguatera diagnosis relies on clinical observations associated with a recent consumption of fish. Although needed, direct confirmation of exposure in subjects showing ciguatera disease symptoms is currently unavailable. We previously reported that ciguatoxins were measurable in the blood of mice exposed to extracts of Pacific ciguatoxins isolated from ...
Marie-Yasmine, Bottein Dechraoui +2 more
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Recovery of ciguatoxin from fish flesh
Toxicon, 1993A mouse bioassay, validated for the quantification of ciguatoxin in up to 20 mg of ether extract from fish flesh, revealed that 63 +/- 14% of spiked ciguatoxin was recovered using a standard extraction procedure. Except for extracts from the least toxic of ciguateric fish (0.1-0.5 nmol ciguatoxin-1/kg fish), signs in mice of intoxication by ciguatoxin (
Lewis, RJ, Sellin, M
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Action of ciguatoxin on human atrial trabeculae
Toxicon, 1992This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained during coronary artery bypass surgery from otherwise ...
Lewis, RJ, Hoy, Aww, McGiffin, DC
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2000
Abstract Ciguatoxin is a partially characterized, heat-stable, lipid soluble compound elaborated by the photosynthetic dino flagellate Gambierdiscus toxicus (40). The toxin is stored in the viscera of fish and passed along the food chain to progressively larger carnivorous fish. Ingestion of these fish leads to neurological, autonomic,
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Abstract Ciguatoxin is a partially characterized, heat-stable, lipid soluble compound elaborated by the photosynthetic dino flagellate Gambierdiscus toxicus (40). The toxin is stored in the viscera of fish and passed along the food chain to progressively larger carnivorous fish. Ingestion of these fish leads to neurological, autonomic,
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